Protein Alignment bbx and cic

DIOPT Version :10

• Sequence 1: NP_001027087.1
• Gene: bbx / 3772670
• FlyBaseID: FBgn0024251
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: XP_061498402.1
• Gene: cic / 11175788
• VectorBaseID: AGAMI1_001189
• Length: 3259
• Species: Anopheles gambiae
• Alignment Length: 903
• Identity: 191/903 - (21%)
• Similarity: 294/903 - (32%)
• Gaps: 341/903 - (37%)

  Fly     8 GGGQQVAQVTPTGAAIKLHFAYNNNSNNSS---SSNISNSNYSGLKTSE-----TKMRN----NK 60
            |..|.||| :.:.||:..|...........   |...|...::.|.||:     |..:|    ..
Mosquito  1450 GPAQHVAQ-SASPAALHHHTIIQQQQQQQQQQLSQTTSQQQHTVLLTSQHQQSLTVPKNGISTGS 1513

  Fly    61 NYTGRALKIVEKIPGASGVIATTSGN---------QGARSLEGYSPAAASYVSGLSRDFLISREL 116
            .|...||..:...|.|   ||.::.:         ..|.| :.|.||||:          .:...
Mosquito  1514 TYQWHALLPIINSPSA---IAKSNLHPHHQHHHYAHMAHS-QAYGPAAAA----------ANTAA 1564

  Fly   117 SQRSGEFLTA--AAKMVSQMGASELRWLPISRTKDKPSSAGEAEAKTLVREGESQGSPGKVAKSA 179
            ...|....||  |::..|.:|:|       |.|..|||||| |.:..:|        |.||....
Mosquito  1565 GPPSSAATTAAVASQQPSPIGSS-------SATTAKPSSAG-ASSMVIV--------PSKVYSPT 1613

  Fly   180 LGDPQPQRTEDQENAFRRIEDVHNYAKLQDCSSDTDDEDDEEEDLDEEEDDEEEAEIQVQLPVQQ 244
              .|.||....:|..                |.|.||:.|         ||..|||     ||:.
Mosquito  1614 --PPPPQLAAGEEMV----------------SIDDDDQGD---------DDVFEAE-----PVKT 1646

  Fly   245 EVTRIRREAAE--------------------------EH-----VDVD---VVTVPQQEQDQYSH 275
            .....:...|:                          .|     :|::   .||..:....:.:.
Mosquito  1647 AAPSTKNSTAQGGAGEQTSNRYAAGNGNNGSGGGGAGSHQLLRGMDIEAPVTVTNSKTTSAESAE 1711

  Fly   276 QVEPRQLQ--------------------------------QDETADNTRPEHHARRPMNAFLIFC 308
            .:..|:.|                                :.::..:.:.:...|||||||:||.
Mosquito  1712 SIAKRRTQSCSAALQAAAAAANGGSSGGAGGGGSGSGTPKEPQSPLSNKKDAKIRRPMNAFMIFS 1776

  Fly   309 KRHRGIVKERYKTLENRAITKILGDWWAALDEQEKHCFTDLAQQNKDAFFNANPNFKWYK----- 368
            ||||.:|.:::...:||.::||||:||.||..:||..:.:||.:.|:|.|.|:|.:||..
Mosquito  1777 KRHRALVHQKHPNQDNRTVSKILGEWWYALKPEEKTKYHELASEVKEAHFKAHPEWKWCSKDRRK 1841

  Fly   369 -------------LPAPPLRT--LATRPSNASAGLL-----IPSEDQPQQQVPTSLQVQWAERGE 413
                         :||.....  ||:...|:..|.:     ..|.|:...:.|:.:        .
Mosquito  1842 SSSSAKEGMVGGGVPASGSGPGGLASAGGNSGRGRMDSFDGNDSFDERSPKTPSDV--------A 1898

  Fly   414 MPRAMLRPNYFKLADETQMG-----ELSSLLQVQVQEKDFALQQVLSETSQFLSAHM---PAGNT 470
            ||         .:...|..|     :.:.::.:.|     |....:.||.:..|..|   |...|
Mosquito  1899 MP---------SVGGGTSTGGGNGSQANDIIPLTV-----APYNTIDETPEPASGVMMMLPPTTT 1949

  Fly   471 NGNGNKRSLQDNNSSNSSEE----EAASGSS---------PNKKVKSSRSCKGKIYQELVNSGQL 522
            ..:|:..|.  |..|..:.|    :|||.||         |..:.|:.......|..|.::.|.
Mosquito  1950 ANHGSVASC--NTGSQQNPEPMVVDAASRSSSPSHQRYAEPEGREKNDERMDISITDEQMDEGG- 2011

  Fly   523 AAIAKKSKARLPPAGNMGGNFVDIPLDAGPNT-------PPVSPPERQGSSPDSMQKHIRSVSES 580
                                  |:..|..|.|       |..:||..|.|:
Mosquito  2012 ----------------------DVAEDDQPMTIADDESVPRKAPPSAQSSN-------------- 2040

  Fly   581 SSSGFFDLEEKIKELPALSLDAYLQRKRSTKKKKKFSGTKKQRNSNSTSGASATSNVAAADAAAK 645
                  |:.|         ||.....|.|....:..||..|.:.::   |..::|...|:.:...
Mosquito  2041 ------DVAE---------LDLKCAEKVSDSDVEDISGNAKGKQNH---GEMSSSQFTASSSTKV 2087

  Fly   646 GAVPLSSEQHVRIKQQQLQAVGSQRRKARKESITRRDVSAIEQEVA---SILPLTINGSYYFNQS 707
            ....:|::.|          .||                  ..:||   ||..||..||   |..
Mosquito  2088 SQSTVSNDYH----------HGS------------------NGDVATDYSIKTLTTAGS---NNG 2121

  Fly   708 GAPKAVNAPVTSSSASPPLSSNSSSSSSSL---------------SSQAAFDVTSSTS 750
            |.|     |.|...   |.|::..:||:||               |:..|...|::|:
Mosquito  2122 GQP-----PTTPGG---PNSASLDASSTSLLTCKPKPIKAGAIGNSTTTATTTTTATA 2171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bbx	NP_001027087.1	HMG-box_HBP2	298..366	CDD:438805	33/67 (49%)
cic	XP_061498402.1	None