Protein Alignment mei-218 and MCM6

DIOPT Version :10

• Sequence 1: NP_728052.2
• Gene: mei-218 / 3772646
• FlyBaseID: FBgn0002709
• Length: 1186
• Species: Drosophila melanogaster
• Sequence 2: NP_011314.2
• Gene: MCM6 / 852673
• SGDID: S000003169
• Length: 1017
• Species: Saccharomyces cerevisiae
• Alignment Length: 1072
• Identity: 188/1072 - (17%)
• Similarity: 338/1072 - (31%)
• Gaps: 365/1072 - (34%)

  Fly   164 SSVRPSDSQ---KSLSDQARCSSSTNITLLSK----DSVQPLTPKSSAQSSP------------- 208
            ||.|||:|.   .|:......||..:..:.|:    .|.||..  |::|:.|
Yeast    11 SSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHV--SNSQTGPFVNDSTQFSSQRL 73

  Fly   209 ---GEKNIQQEQNTPAKSQQEETSPANSVEHQQKTPNSPKEQQKSSVGFTNMQQMASANSLQQQN 270
               |......|.|.||:|.:     :.::.|.:|..:...|:.:.:     .:|.....|:|..:
Yeast    74 QTDGSATNDMEGNEPARSFK-----SRALNHVKKVDDVTGEKVREA-----FEQFLEDFSVQSTD 128

  Fly   271 SSASSLQQQNSSVHSLQKRKSWVNSSQQQRSSVNFIQ---KQRSWVNSSHHQKSSASSLQQKSSE 332
            :.                     ...:..|:.:.|::   ....:::..|.......:|....||
Yeast   129 TG---------------------EVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISE 172

  Fly   333 NSPSKFQQQQQK---------SPANNERSQNNQKSPGIQHSWKQQQQQKPKILQNCPKTSVQQQM 388
            .. .:|....||         :|.....|.:.::|.|.:....:.:||             ...|
Yeast   173 QY-YRFLPFLQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQ-------------DDDM 223

  Fly   389 NPVNHTQSQSERPTELIYLHSRSPAKRASVTNNSSAPIRIAPRQQTTQSSGPSVVHNEDEDVMPP 453
            |       .|..|        |.....|:..|.:||   :|.|..||.:|
Yeast   224 N-------GSSLP--------RDSGSSAAPGNGTSA---MATRSITTSTS--------------- 255

  Fly   454 TPNQSERRQRRFPRRNHNPRMVRSLQAVSREFTESLLEGSSGKTPEKEVVPYQQQEKPRQVKSSP 518
             |.|:|   |.|.....|...|..::.:..|...|||..|...|...||              .|
Yeast   256 -PEQTE---RVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV--------------RP 302

  Fly   519 EIHASSHMRKLAMGSVLN--SNAKEFHPT--------GESHLTHKVSRLSQRRCRQRFTRSLHAK 573
            |::.:|....:....|.|  .:.|...||        ..:..|..|:|          :|.|..:
Yeast   303 ELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTR----------SRFLDWQ 357

  Fly   574 KNNPREQLPNPDSAPEPILEYTSEI------DDQPCPPRQTVDTPIEAIVPPAMIEVSATGNLP- 631
            |...:|   |.:..|...:..|.::      .::..|..:...|.:|.:||    :|:..| ||
Yeast   358 KVRIQE---NANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVP----DVTQLG-LPG 414

  Fly   632 --PVFYFDQQ----------SGIIWSNSSPQIPVEIQSNSVSQSVFRLASLPC--TGVGTTNMDI 682
              |....|.:          ||:          ..::|..|....::::.|.|  ..:|:   :|
Yeast   415 VKPSSTLDTRGISKTTEGLNSGV----------TGLRSLGVRDLTYKISFLACHVISIGS---NI 466

  Fly   683 FTSSPPPIQHMSSSRLPSSISGPTQLSHTLSSPPV--ENQHQQHLWESCIHQDEDLMYSRPLLDM 745
            ..|||....:...:.|        |::..|.:..|  :|:..|.::.:.:..||
Yeast   467 GASSPDANSNNRETEL--------QMAANLQANNVYQDNERDQEVFLNSLSSDE----------- 512

  Fly   746 DQEETQPEQQDQEWQWESEIEPPSFQSENQVVADEHGEENAYLAKDAGPPLERHMIFRAPSQHGQ 810
                                    .....::|.|||..:.          |.|.:   ||:..|.
Yeast   513 ------------------------INELKEMVKDEHIYDK----------LVRSI---APAVFGH 540

  Fly   811 EYPKPDLNCVPSSIKKLHHLISSQYSDYSFVYALSAQISQDCVPMDCFVYLKMILLASIVSIESD 875
            |           ::||                               .:.|:|:......::|..
Yeast   541 E-----------AVKK-------------------------------GILLQMLGGVHKSTVEGI 563

  Fly   876 EVRAPISLCIIATDSLMANRLLNKVGQLAPRFLGPHEYGLQPTFNALPTRF--------NWIVAS 932
            ::|..|::|::...|...::.|..|...|||.:  :..|...:...|....        ..|.|.
Yeast   564 KLRGDINICVVGDPSTSKSQFLKYVVGFAPRSV--YTSGKASSAAGLTAAVVRDEEGGDYTIEAG 626

  Fly   933 PLLLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPVPQLHIDQPLKAAVWTYWQPNNSTNQTLA 997
            .|:||..|:....:::::.......:.:.:|...:.:.:..|...|.|             :|..
Yeast   627 ALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNA-------------RTSI 678

  Fly   998 LAKLCPIFG---------------LPI-------YMGAQASNSLWNSIIQKHNAEGQIVVNDGLS 1040
            ||...|:.|               .||       ::.....|...::.:..|..:..:..::.:.
Yeast   679 LAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHMKRDEAIE 743

  Fly  1041 IP--EDDMRMLIHLLHQRKTTLTDGAQHMLQKYYVISRKERPNVFSSKTY-IVLKQL-------- 1094
            .|  .:.:|..|......|..||..|:..|.:.|...||:....||..:| |.::||
Yeast   744 PPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSE 808

  Fly  1095 ----AECFAKLA----------LRLEVLESDV 1112
                |.|..::.          ||..::..||
Yeast   809 AIARANCVDEITPSFIAEAYDLLRQSIIRVDV 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-218	NP_728052.2	PTZ00112	122..>417	CDD:240274	48/287 (17%)
		SP1-4_N	<152..>287	CDD:425404	28/145 (19%)
		MCM	862..1116	CDD:475121	55/306 (18%)
		MCM_lid	1044..1116	CDD:465534	22/92 (24%)
MCM6	NP_011314.2	MCM_N	112..195	CDD:464206	12/109 (11%)
		MCM	272..836	CDD:214631	123/721 (17%)
		MCM6_C	900..1007	CDD:465688