Protein Alignment mei-218 and dpa

DIOPT Version :10

• Sequence 1: NP_728052.2
• Gene: mei-218 / 3772646
• FlyBaseID: FBgn0002709
• Length: 1186
• Species: Drosophila melanogaster
• Sequence 2: NP_477185.1
• Gene: dpa / 35679
• FlyBaseID: FBgn0015929
• Length: 866
• Species: Drosophila melanogaster
• Alignment Length: 889
• Identity: 167/889 - (18%)
• Similarity: 272/889 - (30%)
• Gaps: 318/889 - (35%)

  Fly   411 SPAKRASV-----TNNSSAPIR-IAPRQ-QTTQSSGPS-VVHNEDEDVMPPTPNQSERRQRRFPR 467
            |||:..||     ...:..|.| ||.:. :|....||. .|...|...:|||...:.......|.
  Fly     3 SPARSPSVGGATPKQGARTPTRGIASQDVETPMRMGPGRAVRPSDNISLPPTSPGNISLPATSPA 67

  Fly   468 RNHNPRMVR-SLQAVSREFTESLLEGSSGKTPEKEVVPYQQQEKPRQVKSSPEIHASSHMRKLAM 531
            |.....|.. .|.:.....|.|.:  .|.:||...:       :...:::.|:|.....:|::|:
  Fly    68 RGLGANMSEIDLSSPLNYGTPSSM--GSIRTPRSGI-------RGTPLRARPDIRTDKRIRQVAI 123

  Fly   532 GSVLNSNAKEFHPTGESHLTHKVSRLSQ-------------RRCRQRFTR--------------- 568
            |   ..:..|..|...|..|..||..||             .:|:.:|..
  Fly   124 G---GGSGLEPIPEKGSETTDPVSESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQDEI 185

  Fly   569 SLHAKKNNP--REQLPNPDSAPEPILEYTS---EIDDQP------CPPRQTV---DTPIEAI--- 616
            |.:...|.|  .::|....:..||.|....   :..||.      |.|::.:   |..|..:
  Fly   186 SENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFE 250

  Fly   617 -VPPAMIE---------VSATGNLPPVFYFDQQ-----SGII--WSNSSPQI------------- 651
             .|.|::|         ...|.|:..:...|..     ||::  .||..|::
  Fly   251 RYPAALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFS 315

  Fly   652 -PVEIQSNSVSQSVFRLASLPCTGVGTT-------NMDIFT--------SSPPPIQHMSSSRLP- 699
             .||:....::|...      ||...|.       |...||        .||   ..|::.:.|
  Fly   316 TTVEVDRGRINQPTL------CTNCNTNHCFRLIHNRSEFTDKQLVKLQESP---DDMAAGQTPH 371

  Fly   700 ----------------------SSISGPTQLSHTLSSPPVENQHQQHLWESCIHQDEDLMYSRPL 742
                                  :.|...|.|.....|..|::.::.|:         |:::.|.:
  Fly   372 NVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHV---------DVVHFRKV 427

  Fly   743 LDMDQEETQPEQQDQEWQWESEIEPPSFQSENQVVADEHGEENAYLAKDAGPPLERHMIFRAPSQ 807
                                         ...::..||.|:::.:      || ||..:.:..::
  Fly   428 -----------------------------DNKRLYEDEEGKDHIF------PP-ERVELLQLLAK 456

  Fly   808 HGQEYPKPDLNCVPSSIKKLHHLISSQYSDYSFVYALSAQISQDCVPMDCFVYLKMILLASI--- 869
                  |||:                 |...:...|.|...:.|        ..|.|||...
  Fly   457 ------KPDI-----------------YDRLARAIAPSIYENDD--------IKKGILLQLFGGT 490

  Fly   870 ----VSIESDEVRAPISLCIIATDSLMANRLLNKVGQLAPRF-----LGPHEYGLQPTFNALP-T 924
                .::.....|:.|.|.:........:::|..|..|.||.     .|....||.......| |
  Fly   491 KKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPET 555

  Fly   925 RFNWIVASPLLLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPVPQLHIDQPLKAAVWTYWQPN 989
            |...:....|:||..||....::::::......|.:.:|
  Fly   556 RQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVME-------------------------- 594

  Fly   990 NSTNQTLALAK---LCPIFG-LPIYMGAQASNSLWN---SIIQKHNAEGQIVVNDGLSI----PE 1043
               .|||::||   :|.:.. ..|...|..:.|.||   :||........::....|..    |:
  Fly   595 ---QQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQ 656

  Fly  1044 D---DMRMLIHLL-------HQRK---------------------TTLTDGAQHMLQKYYVISRK 1077
            |   |.|:..||:       |:.:                     .||:|.||..|.:.||..||
  Fly   657 DEIFDKRLASHLVSLYYVTRHEEEDTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRK 721

  Fly  1078 ---------ERPNVFSSKTYIVLKQLAECFAKLALRLEVLESDV 1112
                     ..|....|     |.:|:|..||:.|..:|...||
  Fly   722 VGAGRGQISAYPRQLES-----LIRLSEAHAKVRLSNQVELLDV 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-218	NP_728052.2	PTZ00112	122..>417	CDD:240274	3/5 (60%)
		SP1-4_N	<152..>287	CDD:425404
		MCM	862..1116	CDD:475121	67/315 (21%)
		MCM_lid	1044..1116	CDD:465534	27/109 (25%)
dpa	NP_477185.1	PHA03307	2..>150	CDD:223039	39/158 (25%)
		MCM_N	165..267	CDD:464206	17/101 (17%)
		MCM	270..772	CDD:214631	110/610 (18%)