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Protein Alignment mei-218 and mcm6

DIOPT Version :9

Sequence 1:	NP_001027068.1	Gene:	mei-218 / 3772646	FlyBaseID:	FBgn0002709	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	NP_596614.1	Gene:	mcm6 / 2540784	PomBaseID:	SPBC211.04c	Length:	892	Species:	Schizosaccharomyces pombe

Alignment Length:	903	Identity:	166/903 - (18%)
Similarity:	293/903 - (32%)	Gaps:	301/903 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 ASVTNNSSAPIRIAPRQQTTQSSGPSVVHNEDEDVMPPTPNQSERRQ-----RRFPRR---NHNP 472
            ||..||:|.|......|.:.....|:|       .||..|..|...:     :|.|..   ...|
pombe     5 ASQGNNASTPAYRYGFQTSEVGDRPTV-------SMPSQPESSAMLEDDGMVKRKPFAAIGEAIP 62

  Fly   473 RMVRSL-QAVSREFTESLLEGSSGKTPEKEVVPYQQQEK--PRQVK--SSPEIHA--------SS 524
            :::.:. ::|...|.|.||..|..:....:.:|...|||  .:|:.  :..|||.        :|
pombe    63 KVIDTTGESVREAFEEFLLSFSDDRVAGGDALPSASQEKYYVQQIHGLAMYEIHTVYVDYKHLTS 127

  Fly   525 HMRKLAMGSVLNSNAKEFHPTGESHLTHKVSRLSQRRCRQRFTRSLHAKKNNPREQLPNPDSAPE 589
            :...||:..|  .....|.|    .|...:.:|.: :....:.||..:::|  ....||..::
pombe   128 YNDVLALAIV--EQYYRFSP----FLLRALQKLIE-KFEPEYYRSSLSREN--ASLSPNFKAS-- 181

  Fly   590 PILEYTSEIDDQPCPPRQTV-DTPIEAIVPPAMI--EVSATGNLPPVF----YFDQQSGIIWSN- 646
               :.|..:.....|.|.|: |...:.|.....|  .|:.|..:.|..    :..::...:.||
pombe   182 ---DKTFALAFYNLPFRSTIRDLRTDRIGRLTTITGTVTRTSEVRPELAQGTFICEECHTVVSNV 243

  Fly   647 ------SSP-QIPVEIQSN------SVSQSVFR---------------LASLP------------ 671
                  :.| |.|.|:.:|      ::|||.|:               ..|:|
pombe   244 EQAFRYTEPTQCPNELCANKRSWRLNISQSSFQDWQKVRIQENSNEIPTGSMPRTLDVILRGDIV 308

  Fly   672 --------C--TGVGTTNMDIFTSSPPPIQHMS-------SSRLPSSISGPTQLSHTLSSPPVEN 719
                    |  ||:.....|:.....|.::..:       ..|....::|       |.|..|.:
pombe   309 ERAKAGDKCAFTGILIAVPDVSQLGIPGVKPEAYRDSRNFGGRDADGVTG-------LKSLGVRD 366

  Fly   720 QHQQHLWESCIHQDEDLMYSRPLLDMDQEETQP-EQQDQEWQWESEIEPPSFQSENQVVADEHGE 783
            ...:..:.:|:.|.:| ...:...|:..:.:|. |:||:           ..||.:|   :|..:
pombe   367 LTYKLSFLACMVQPDD-ANDKSGADVRGDGSQGIEEQDE-----------FLQSLSQ---EEIDD 416

  Fly   784 ENAYLAKDAGPPLERHMIFR-----APSQHGQEYPKPDLNCVPSSIKKLHHLISSQYSDYSFVYA 843
            ..|.:..|       |:..|     |||.:|.|..|
pombe   417 LRAMVHSD-------HIYSRLTNSLAPSVYGHEIIK----------------------------- 445

  Fly   844 LSAQISQDCVPMDCFVYLKMILLASIVSI-----ESDEVRAPISLCIIATDSLMANRLLNKVGQL 903
                              |.|||..:..:     |...:|..:::||:...|...::.|..|...
pombe   446 ------------------KGILLQLMGGVHKLTPEGINLRGDLNICIVGDPSTSKSQFLKYVCNF 492

  Fly   904 APRFLGPHEYGLQPTFNAL--------PTRFNWIVASPLLLAQQGVYYAGDWNRLSKDQGCQLEK 960
            .||.:  :..|...:...|        .|....|.|..|:||..|:....:::::.......:.:
pombe   493 LPRAI--YTSGKASSAAGLTAAVVKDEETGDFTIEAGALMLADNGICAIDEFDKMDLSDQVAIHE 555

  Fly   961 CIENGAVPVPQLHIDQPLKAAVWTYWQPNNSTNQTLALAKLCPIFGLPIYMGAQASNSLWNSIIQ 1025
            .:|...:.:.:..|...|.|             :|..||...||.|
pombe   556 AMEQQTISIAKAGIQATLNA-------------RTSILAAANPIGG------------------- 588

  Fly  1026 KHNAEGQIVVNDGLSIP-----------------EDDMRMLIHL--LHQRKTTLTDGAQ------ 1065
            ::|.:..:..|..:|.|                 ..|..:..|:  :|:    |.|.|.
pombe   589 RYNRKTTLRNNINMSAPIMSRFDLFFVVLDECNESVDRHLAKHIVDIHR----LRDDAMQPEFST 649

  Fly  1066 HMLQKYYVISRKERPNVFSS------KTYIVLKQL----AECFAKLALRLEV--LESDVCVAIFH 1118
            ..||:|...:|..:|.:.:.      |.|   |||    |:...|.:.|:.|  |||.:
pombe   650 EQLQRYIRYARTFKPKLNTESCAEIVKKY---KQLRMDDAQGAGKNSYRITVRQLESMI------ 705

  Fly  1119 CEHFVQGIFGAKENQAPPAVFNFNVISCIDP-YMNKFTRWLLQYLNSYEDEELGMHAD 1175
                          :...|:...|.:..|.| ::|:....|.|.:...|.:::.:..|
pombe   706 --------------RLSEAIARANCVDDITPAFVNEAYSLLRQSIIHVERDDIEVEED 749

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.