DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-218 and Mcmdc2

DIOPT Version :9

Sequence 1:	NP_001027068.1	Gene:	mei-218 / 3772646	FlyBaseID:	FBgn0002709	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	NP_808390.2	Gene:	Mcmdc2 / 240697	MGIID:	3045334	Length:	681	Species:	Mus musculus

Alignment Length:	532	Identity:	127/532 - (23%)
Similarity:	211/532 - (39%)	Gaps:	104/532 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   702 ISGPTQLSHTLSSPPVENQHQQHLWESCIHQDEDLMYSRPLLDMDQEETQPEQQDQEWQWESEIE 766
            :.|.|:      |..|.|.....|..|.:.:|...   |.|.|....|....:....:|.:|:.:
Mouse   169 VPGATE------SATVRNDFLCSLCSSSLQEDRKF---RVLGDKQIVEIITTKMFHAFQGDSKNQ 224

  Fly   767 PPSFQSENQVVADEHGEE----NAYLAKDAGPP-----------LERHMIFRAPSQHGQEYPKPD 816
            |..|||....:.||...:    |.|  |..|.|           :|.:.|    :.|..:.|..
Mouse   225 PFRFQSLGIFLRDELVNKMKIGNEY--KIIGIPVCVKTSQTALCVEANNI----TPHTAKVPLG- 282

  Fly   817 LNCVPSSIKKLHHLISSQYSDYSFVYALSAQISQDCVPMDCFVYLKMILLASIVSIE--SDEVRA 879
               :..:.::|..|.||  |.:.|...|:...:...|....:..||:.||.|:|...  :.|...
Mouse   283 ---ISDNFRRLLSLTSS--SCWKFTAMLANVFASQIVAPGTYNLLKLCLLMSLVQTRDCNRERED 342

  Fly   880 PISLCIIATDSLMANRLLNKVGQLAPRFLGPHEYGLQ--------PTF--NALPTRFNWIVASPL 934
            .:.:.:|.:|:|:.:||||....|..|       |::        ||.  |...|....|.|...
Mouse   343 CLDILVITSDTLLVDRLLNFSMNLVSR-------GIRHPVCTEVFPTVSRNKYGTGAVSIQAGSA 400

  Fly   935 LLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPV--PQL----HIDQ----PLKAAVWTYWQPN 989
            |||:.|:.:.||.....||:..||:..:|:.:|.|  |..    ..||    |::.:.|::...:
Mouse   401 LLAKGGICFIGDLTSHKKDKLEQLQSALESRSVTVFIPGKKFGDDFDQQMTFPIQCSFWSFVDMD 465

  Fly   990 NSTNQ--------------TLALAKLCPIFGLPIYMG-AQASNSLWNSIIQKHNAEGQIVVNDGL 1039
            :|:.:              :|..|.|...|||.|... |...:.|..::  :|..: :.|..:||
Mouse   466 SSSRRNVQKTSTLIGQMDCSLIPANLAEAFGLLINCSEASPCHPLLPTV--QHTLK-KAVEPEGL 527

  Fly  1040 ------SIPEDDMRMLIHLLHQRKTTLTDGAQHMLQKYYVISRKER-PNVFSSK------TYIVL 1091
                  ....:|...|:..........:..|:.|:..||:.||:.| .::..||      .|:|
Mouse   528 LYLASKQFTTEDFEKLLAFAKSLNMEFSLEAERMIHGYYLASRRIRTDSIHGSKLSASALKYLV- 591

  Fly  1092 KQLAECFAKLALRLEVLESDVCVAIFHCEHFVQGIFGAKE-NQAPPAVFNFNV-----ISCIDPY 1150
             .|:|..|:|:||..||..|..:|....|..:...:||.. ..||.|:|.|.:     :...|.|
Mouse   592 -SLSEAHARLSLRTTVLREDALIAALLLEISLTLRYGATPFCVAPNALFPFELYNEEYLEQRDLY 655

  Fly  1151 MNKFTRWLLQYL 1162
            :.:..:.|.|::
Mouse   656 LTQCQQQLQQFI 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-218	NP_001027068.1	PTZ00112	122..>417	CDD:240274
mei-218	NP_001027068.1	MCM	<1023..1116	CDD:278895	26/105 (25%)
Mcmdc2	NP_808390.2	MCM	<395..621	CDD:355777	58/230 (25%)
Mcmdc2	NP_808390.2	MCM_lid	<557..622	CDD:375383	22/66 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009781
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870