Protein Alignment mei-218 and Mcmdc2

DIOPT Version :10

• Sequence 1: NP_728052.2
• Gene: mei-218 / 3772646
• FlyBaseID: FBgn0002709
• Length: 1186
• Species: Drosophila melanogaster
• Sequence 2: NP_808390.2
• Gene: Mcmdc2 / 240697
• MGIID: 3045334
• Length: 681
• Species: Mus musculus
• Alignment Length: 532
• Identity: 127/532 - (23%)
• Similarity: 211/532 - (39%)
• Gaps: 104/532 - (19%)

  Fly   702 ISGPTQLSHTLSSPPVENQHQQHLWESCIHQDEDLMYSRPLLDMDQEETQPEQQDQEWQWESEIE 766
            :.|.|:      |..|.|.....|..|.:.:|...   |.|.|....|....:....:|.:|:.:
Mouse   169 VPGATE------SATVRNDFLCSLCSSSLQEDRKF---RVLGDKQIVEIITTKMFHAFQGDSKNQ 224

  Fly   767 PPSFQSENQVVADEHGEE----NAYLAKDAGPP-----------LERHMIFRAPSQHGQEYPKPD 816
            |..|||....:.||...:    |.|  |..|.|           :|.:.|    :.|..:.|..
Mouse   225 PFRFQSLGIFLRDELVNKMKIGNEY--KIIGIPVCVKTSQTALCVEANNI----TPHTAKVPLG- 282

  Fly   817 LNCVPSSIKKLHHLISSQYSDYSFVYALSAQISQDCVPMDCFVYLKMILLASIVSIE--SDEVRA 879
               :..:.::|..|.||  |.:.|...|:...:...|....:..||:.||.|:|...  :.|...
Mouse   283 ---ISDNFRRLLSLTSS--SCWKFTAMLANVFASQIVAPGTYNLLKLCLLMSLVQTRDCNRERED 342

  Fly   880 PISLCIIATDSLMANRLLNKVGQLAPRFLGPHEYGLQ--------PTF--NALPTRFNWIVASPL 934
            .:.:.:|.:|:|:.:||||....|..|       |::        ||.  |...|....|.|...
Mouse   343 CLDILVITSDTLLVDRLLNFSMNLVSR-------GIRHPVCTEVFPTVSRNKYGTGAVSIQAGSA 400

  Fly   935 LLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPV--PQL----HIDQ----PLKAAVWTYWQPN 989
            |||:.|:.:.||.....||:..||:..:|:.:|.|  |..    ..||    |::.:.|::...:
Mouse   401 LLAKGGICFIGDLTSHKKDKLEQLQSALESRSVTVFIPGKKFGDDFDQQMTFPIQCSFWSFVDMD 465

  Fly   990 NSTNQ--------------TLALAKLCPIFGLPIYMG-AQASNSLWNSIIQKHNAEGQIVVNDGL 1039
            :|:.:              :|..|.|...|||.|... |...:.|..::  :|..: :.|..:||
Mouse   466 SSSRRNVQKTSTLIGQMDCSLIPANLAEAFGLLINCSEASPCHPLLPTV--QHTLK-KAVEPEGL 527

  Fly  1040 ------SIPEDDMRMLIHLLHQRKTTLTDGAQHMLQKYYVISRKER-PNVFSSK------TYIVL 1091
                  ....:|...|:..........:..|:.|:..||:.||:.| .::..||      .|:|
Mouse   528 LYLASKQFTTEDFEKLLAFAKSLNMEFSLEAERMIHGYYLASRRIRTDSIHGSKLSASALKYLV- 591

  Fly  1092 KQLAECFAKLALRLEVLESDVCVAIFHCEHFVQGIFGAKE-NQAPPAVFNFNV-----ISCIDPY 1150
             .|:|..|:|:||..||..|..:|....|..:...:||.. ..||.|:|.|.:     :...|.|
Mouse   592 -SLSEAHARLSLRTTVLREDALIAALLLEISLTLRYGATPFCVAPNALFPFELYNEEYLEQRDLY 655

  Fly  1151 MNKFTRWLLQYL 1162
            :.:..:.|.|::
Mouse   656 LTQCQQQLQQFI 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-218	NP_728052.2	PTZ00112	122..>417	CDD:240274
		SP1-4_N	<152..>287	CDD:425404
		MCM	862..1116	CDD:475121	76/303 (25%)
		MCM_lid	1044..1116	CDD:465534	22/78 (28%)
Mcmdc2	NP_808390.2	MCM	<395..621	CDD:475121	58/230 (25%)
		MCM_lid	<557..622	CDD:465534	22/66 (33%)