Protein Alignment mei-218 and MCMDC2

DIOPT Version :10

• Sequence 1: NP_728052.2
• Gene: mei-218 / 3772646
• FlyBaseID: FBgn0002709
• Length: 1186
• Species: Drosophila melanogaster
• Sequence 2: NP_775789.3
• Gene: MCMDC2 / 157777
• HGNCID: 26368
• Length: 681
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 132/537 - (24%)
• Similarity: 214/537 - (39%)
• Gaps: 108/537 - (20%)

  Fly   702 ISGPTQLSHTLSSPPVENQHQQHLWESCIHQDEDLMYSRPLLDMDQEETQPEQQDQEWQWESEIE 766
            :.|.|:      |..:.|....:|..|.:.:|...   |.|.|....|....:..:.:|..|..:
Human   169 VPGATE------SATIRNDFLCNLCASSLQEDRKF---RVLGDKQIVEIIATKALRAFQGYSNNQ 224

  Fly   767 PPSFQSENQVVADEHGEE----NAYLAKDAGPP-----------LERHMIFRAPSQHGQEYPKPD 816
            |..|||....:.||...:    |.|  |..|.|           :|.:.|....|:
Human   225 PFRFQSLTIFLRDESVNKMNIGNEY--KIIGIPTCVKTSQTAVCIEANSITFCNSK--------- 278

  Fly   817 LNCVPSSI----KKLHHLISSQYSDYSFVYALSAQISQDCVPMDCFVYLKMILLASIVSI--ESD 875
               |||.|    :.|..|.||  |.:.|...|:...:....|...:..||:.||.|:|..  .:.
Human   279 ---VPSGISDNFRCLLSLTSS--SCWKFTAILANIFASQITPPGTYNLLKLCLLMSLVQTTDRNK 338

  Fly   876 EVRAPISLCIIATDSLMANRLLNKVGQLAPRFLGPHEYGLQ--------PTF--NALPTRFNWIV 930
            |:...:.:.||.:|:|:.:||||....|.||       |::        ||.  |...|....|.
Human   339 ELEDCLDILIITSDTLLIDRLLNFSINLVPR-------GIRHLVSTEIFPTLSRNKYGTGAVSIQ 396

  Fly   931 ASPLLLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPV--PQL----HIDQ----PLKAAVWTY 985
            |...|||:.|:.:.||.....||:..||:..:|:.::.|  |..    .|||    |::.:.|::
Human   397 AGSALLAKGGICFIGDLASHKKDKLEQLQTVLESRSITVYIPGKKFGEDIDQQMTFPVQCSFWSF 461

  Fly   986 WQPNNSTNQ--------------TLALAKLCPIFGLPIYMGAQAS-----NSLWNSIIQKHNAEG 1031
            ...::|:.:              :|..|.|...|||.|.....:.     .::.:::.:..|.||
Human   462 VDVDSSSRRNAQKINTLIGQMDCSLIPANLVEAFGLLINCNESSPCHPFLPTVQHTLNKAINPEG 526

  Fly  1032 QIVVNDGLSIPEDDMRMLIHLLHQRKTTLTDGAQHMLQKYYVISRKERP-NVFSSK------TYI 1089
             :..........:|...|:..........:..|:.|...||:.||:.|. :|..||      .|:
Human   527 -LFYAASRQFTTEDFEKLLAFAKNLNVEFSLEAERMTHGYYLASRRIRTGSVCGSKLSASALKYL 590

  Fly  1090 VLKQLAECFAKLALRLEVLESDVCVAIFHCEHFVQGIFGAKE-NQAPPAVFNFNV-----ISCID 1148
            |.  |:|..|:|.||.:||:.||.:|....|..:...:||.. ..||.|||.|.:     :...|
Human   591 VF--LSEAHARLNLRNKVLKEDVLIAALLFETSLTLKYGATVFCVAPNAVFPFELYNEEYLEQRD 653

  Fly  1149 PYMNKFTRWLLQYLNSY 1165
            .|:.:..:.|.|::.:|
Human   654 LYLTQCQQQLEQFIATY 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-218	NP_728052.2	PTZ00112	122..>417	CDD:240274
		SP1-4_N	<152..>287	CDD:425404
		MCM	862..1116	CDD:475121	77/301 (26%)
		MCM_lid	1044..1116	CDD:465534	24/78 (31%)
MCMDC2	NP_775789.3	MCM	<390..621	CDD:475121	58/233 (25%)