DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-218 and MCMDC2

DIOPT Version :9

Sequence 1:NP_001027068.1 Gene:mei-218 / 3772646 FlyBaseID:FBgn0002709 Length:1186 Species:Drosophila melanogaster
Sequence 2:NP_775789.3 Gene:MCMDC2 / 157777 HGNCID:26368 Length:681 Species:Homo sapiens


Alignment Length:537 Identity:132/537 - (24%)
Similarity:214/537 - (39%) Gaps:108/537 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   702 ISGPTQLSHTLSSPPVENQHQQHLWESCIHQDEDLMYSRPLLDMDQEETQPEQQDQEWQWESEIE 766
            :.|.|:      |..:.|....:|..|.:.:|...   |.|.|....|....:..:.:|..|..:
Human   169 VPGATE------SATIRNDFLCNLCASSLQEDRKF---RVLGDKQIVEIIATKALRAFQGYSNNQ 224

  Fly   767 PPSFQSENQVVADEHGEE----NAYLAKDAGPP-----------LERHMIFRAPSQHGQEYPKPD 816
            |..|||....:.||...:    |.|  |..|.|           :|.:.|....|:         
Human   225 PFRFQSLTIFLRDESVNKMNIGNEY--KIIGIPTCVKTSQTAVCIEANSITFCNSK--------- 278

  Fly   817 LNCVPSSI----KKLHHLISSQYSDYSFVYALSAQISQDCVPMDCFVYLKMILLASIVSI--ESD 875
               |||.|    :.|..|.||  |.:.|...|:...:....|...:..||:.||.|:|..  .:.
Human   279 ---VPSGISDNFRCLLSLTSS--SCWKFTAILANIFASQITPPGTYNLLKLCLLMSLVQTTDRNK 338

  Fly   876 EVRAPISLCIIATDSLMANRLLNKVGQLAPRFLGPHEYGLQ--------PTF--NALPTRFNWIV 930
            |:...:.:.||.:|:|:.:||||....|.||       |::        ||.  |...|....|.
Human   339 ELEDCLDILIITSDTLLIDRLLNFSINLVPR-------GIRHLVSTEIFPTLSRNKYGTGAVSIQ 396

  Fly   931 ASPLLLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPV--PQL----HIDQ----PLKAAVWTY 985
            |...|||:.|:.:.||.....||:..||:..:|:.::.|  |..    .|||    |::.:.|::
Human   397 AGSALLAKGGICFIGDLASHKKDKLEQLQTVLESRSITVYIPGKKFGEDIDQQMTFPVQCSFWSF 461

  Fly   986 WQPNNSTNQ--------------TLALAKLCPIFGLPIYMGAQAS-----NSLWNSIIQKHNAEG 1031
            ...::|:.:              :|..|.|...|||.|.....:.     .::.:::.:..|.||
Human   462 VDVDSSSRRNAQKINTLIGQMDCSLIPANLVEAFGLLINCNESSPCHPFLPTVQHTLNKAINPEG 526

  Fly  1032 QIVVNDGLSIPEDDMRMLIHLLHQRKTTLTDGAQHMLQKYYVISRKERP-NVFSSK------TYI 1089
             :..........:|...|:..........:..|:.|...||:.||:.|. :|..||      .|:
Human   527 -LFYAASRQFTTEDFEKLLAFAKNLNVEFSLEAERMTHGYYLASRRIRTGSVCGSKLSASALKYL 590

  Fly  1090 VLKQLAECFAKLALRLEVLESDVCVAIFHCEHFVQGIFGAKE-NQAPPAVFNFNV-----ISCID 1148
            |.  |:|..|:|.||.:||:.||.:|....|..:...:||.. ..||.|||.|.:     :...|
Human   591 VF--LSEAHARLNLRNKVLKEDVLIAALLFETSLTLKYGATVFCVAPNAVFPFELYNEEYLEQRD 653

  Fly  1149 PYMNKFTRWLLQYLNSY 1165
            .|:.:..:.|.|::.:|
Human   654 LYLTQCQQQLEQFIATY 670

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-218NP_001027068.1 PTZ00112 122..>417 CDD:240274
MCM <1023..1116 CDD:278895 27/99 (27%)
MCMDC2NP_775789.3 PTZ00111 <358..>435 CDD:173403 25/83 (30%)
MCM <514..622 CDD:278895 29/110 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0009781
OrthoInspector 1 1.000 - - oto90864
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R7620
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.900

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