DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-218 and mcmdc2

DIOPT Version :9

Sequence 1:	NP_001027068.1	Gene:	mei-218 / 3772646	FlyBaseID:	FBgn0002709	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	XP_012820732.2	Gene:	mcmdc2 / 105947627	XenbaseID:	XB-GENE-1012270	Length:	684	Species:	Xenopus tropicalis

Alignment Length:	429	Identity:	94/429 - (21%)
Similarity:	170/429 - (39%)	Gaps:	77/429 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   793 GPPLERHMIFRAPSQHGQEYPKPDLNCVPSSIKKLHHLISSQYSDYSFVYALSAQISQDCVPMDC 857
            ||    |:.....:.:..:|.:...:.:..|.:.||....|  |.:.|...|:...:...:|:..
Frog   266 GP----HISVCIEANNIHQYIEESPSTISKSFQTLHSATMS--SPWIFTGILANMFASQVIPLGV 324

  Fly   858 FVYLKMILLASIVSI--ESDEVRAPISLCIIATDSLMANRLLNKVGQLAPRFLGPHEYGLQPTFN 920
            ...||:.:|.|:|..  |..:..:.:.|.::.:|:|:.:||:.....|.||  |...|.....|.
Frog   325 HNTLKLCILLSLVQTCKEEKDNGSFLDLLVVTSDTLIVDRLMRYSICLVPR--GVQHYTSNDLFA 387

  Fly   921 AL-----PTRFNWIVASPLLLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPV----------- 969
            .:     .|....|.|...|:|..|:.:.||.:...||:...|:..:|:.:..|
Frog   388 TVIKDIRGTGTATIQAGSALMANGGICFMGDLSLHKKDKLDHLQSVLESRSTSVFIPGKKYGEDV 452

  Fly   970 -PQLHIDQPLKAAVWTYWQ--PNNSTNQ----------TLALAKLCPIFGLPIYMGAQASNSLWN 1021
             .|:.|  |::.:.|:|..  |....::          ::..:.|...||:.||.         |
Frog   453 NHQICI--PVQCSFWSYMDSYPKKHVHRDTTFIGQVDLSVVPSNLLDAFGMFIYC---------N 506

  Fly  1022 SIIQKHNAEGQIVVNDGLS---IPE------------DDMRMLIHLLHQRKTTLTDGAQHMLQKY 1071
            .|:  ||.....:|:..|.   .||            .|...||......:..::..:..::..|
Frog   507 EIL--HNQPPLFLVHHNLQRAVNPETYIYPSSELYTTQDYEKLIAFAKNIQVNISKKSVTLIHGY 569

  Fly  1072 YVISRKERPNVFSS----KTYIVLKQLAECFAKLALRLEVLESDVCVAIFHCE------HFVQGI 1126
            |:.||:.|.:...|    .....|..::|..|||:||.||||.||.||:...|      |.....
Frog   570 YLASRRVRTDTHGSTMPTSALRHLISMSEAHAKLSLRREVLEEDVLVAVLLFELSLTLKHGSSAF 634

  Fly  1127 FGAKENQAPPAVFNFNVISCIDPYMNKFTRWLLQYLNSY 1165
            :.:.....|..:::.:.:...|.|:.:..:.|||::.:|
Frog   635 YVSPSALFPVELYDESSLHQRDLYLRETYQQLLQFVFTY 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-218	NP_001027068.1	PTZ00112	122..>417	CDD:240274
mei-218	NP_001027068.1	MCM	<1023..1116	CDD:278895	30/111 (27%)
mcmdc2	XP_012820732.2	Mcm2	46..625	CDD:224162	86/379 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009781
OrthoInspector	1	1.000	-	-		oto104652
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7620
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030