Protein Alignment mei-218 and mcm8

DIOPT Version :10

• Sequence 1: NP_728052.2
• Gene: mei-218 / 3772646
• FlyBaseID: FBgn0002709
• Length: 1186
• Species: Drosophila melanogaster
• Sequence 2: XP_002665161.2
• Gene: mcm8 / 100333576
• ZFINID: ZDB-GENE-120927-1
• Length: 852
• Species: Danio rerio
• Alignment Length: 818
• Identity: 147/818 - (17%)
• Similarity: 278/818 - (33%)
• Gaps: 247/818 - (30%)

  Fly   485 FTESLLEGSSGKTPEKEVVPYQQQEK--PRQVKSSPEIHASSHMRKLAMGSV------LNSNAKE 541
            |:|..:|.|          ||.::.|  .:...|..:::....:.:  .||:      |.||.:.
Zfish    94 FSEGFVESS----------PYVEKIKVFEQYFTSQIDLYDKDEIER--KGSILVDYKDLLSNKQV 146

  Fly   542 FHPTGESHLTHKVSRLSQR-------RCRQRFTRSL--HAKKNNPREQLPNPDSAPEPILE---- 593
            .|...:  |...:..:.::       ...|..|..|  ||.:...:|:||   :...||:.
Zfish   147 SHSLPD--LARDLKEMPEKILDCLGVAIHQVLTLDLERHAAELQGQEELP---AGIRPIINIPHI 206

  Fly   594 ----YTSEIDDQPCPPRQTVDTPIE---AIVPPAMIEVSATGNLPPV---FYF------DQQSGI 642
                |..|    |..|.:::...:.   .::...::.||   |:.|:   ..|      |.|| :
Zfish   207 SARLYNYE----PLTPLKSLRANLYGKFVVIRGTVVRVS---NIKPLCMKLAFVCNSCGDTQS-V 263

  Fly   643 IWSNSSPQIPVE-IQSNSVSQSVFRLASLPCTGVGTTNMDIFTSSPPPIQHM------SSSRLPS 700
            ...:....:|.: :||....:|.....|.|.    |..:|..|..   :|.:      .|.|:|.
Zfish   264 TLPDGKYTMPTKCLQSECRGRSFTPNRSSPF----TLTVDWQTIK---VQELMSGDQRESGRIPR 321

  Fly   701 SISGPTQLSHTLSSPPVENQHQQHLWESCIHQDEDLMYSRPLLDMDQEETQPEQQDQEWQWESEI 765
            :|               |.:..|.|.:||:  ..|::....::.:..||.....:..:..:...|
Zfish   322 TI---------------ECELTQDLVDSCV--PGDMVTITGVIKVSNEEGSTRNKKDKCMFLLYI 369

  Fly   766 EPPSFQSENQVVADEHGEENAYLAKDAGPPLERHMIFRAPSQHGQEYPKPDLNCVPSSIKKLHHL 830
            :..|       |::..|:::..:::..|         :.||             |..|||.|:.:
Zfish   370 QANS-------VSNSKGQKSKAVSESEG---------QGPS-------------VEFSIKDLYAI 405

  Fly   831 ISSQYSDYSFVYALSAQISQDCVPMDCFVY--------LKMILLASIVSIESDEVRAPI----SL 883
            ...|..:..|     ..|.....|:   :|        |.:.|.........|:.|.||    .:
Zfish   406 QEIQAQEDLF-----KLIVNSLCPV---IYGHLLVKAGLALALFGGCQKYVDDKNRIPIRGDPHM 462

  Fly   884 CIIATDSLMANRLLNKVGQLAPRFLGPHEYGLQPTFNALPTRFN--------WIVASPLLLAQQG 940
            .|:....|..:::|..|..:|||  |.:..|...|.:.|....:        .:.|..|:|..||
Zfish   463 LIVGDPGLGKSQMLQAVCNVAPR--GVYVCGNTTTTSGLTVSLSRDSGSGDYALEAGALVLGDQG 525

  Fly   941 VYYAGDWNRLSKDQGCQLEKCIENGAVPVPQLHIDQPLKA---------AVWTYWQPNNSTNQTL 996
            :....:::::.......|| .:|..::.:.:..|...|.|         .|..::....:.::.|
Zfish   526 ICCIDEFDKMGSQHQALLE-AMEQQSISLAKAGIVCTLPARTSIIAAANPVGGHYNKGKTVSENL 589

  Fly   997 AL-AKLCPIFGLPIYMGAQASNSLWNSIIQKH---------------------NAEGQIVVNDGL 1039
            .: :.|...|.| :::.....|...:.::.:|                     ..|..|.:.:..
Zfish   590 KMGSALLSRFDL-VFILLDTPNEDHDHLLSEHVMAMRAGKSGAVSGAAATRFNTHESSISILEVS 653

  Fly  1040 S------------------IPEDDMRMLI----HLLHQRKTTLTDGAQHMLQKYYVISRKERPNV 1082
            |                  ||...:|..:    |.:|   .||:..|..:||.:|:..||:  |.
Zfish   654 SEKPLADTLKLVPGEAFDPIPHQLLRKYVGYARHYVH---PTLSAEAAQVLQDFYLELRKQ--NQ 713

  Fly  1083 FSSKTYIVLKQ------LAECFAKLALRLEVLESDVCVAIFHCEHFVQGIFGAKENQAPPAVFNF 1141
            .:..|.|..:|      |.|..|::.||.:..:||....:...:|
Zfish   714 TADSTPITTRQLESLIRLTEARARVELREKATQSDAEDVVEIMKH-------------------- 758

  Fly  1142 NVISCIDPYMNKFTRWLLQYLNSYEDEELGMHADKRRR 1179
               |..|.|.::|.|.      .::..:||.....|.:
Zfish   759 ---SLTDTYSDEFGRL------DFDRSQLGSGMSNRSK 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-218	NP_728052.2	PTZ00112	122..>417	CDD:240274
		SP1-4_N	<152..>287	CDD:425404
		MCM	862..1116	CDD:475121	61/324 (19%)
		MCM_lid	1044..1116	CDD:465534	22/81 (27%)
mcm8	XP_002665161.2	Mcm2	100..844	CDD:440854	145/812 (18%)