DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shawn and SLC25A40

DIOPT Version :9

Sequence 1:	NP_001027071.1	Gene:	Shawn / 3772641	FlyBaseID:	FBgn0031039	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_061331.2	Gene:	SLC25A40 / 55972	HGNCID:	29680	Length:	338	Species:	Homo sapiens

Alignment Length:	351	Identity:	159/351 - (45%)
Similarity:	212/351 - (60%)	Gaps:	29/351 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DPRFR------IRPLQQVASACTGAMVTACFMTPLDVIKTRLQAQQQALLSNKCFLYCNGLMDHI 90
            ||..|      :.||||:.::||||::|:..:|||||:|.|||||...|...|||:|.||||||:
Human     2 DPETRGQEIIKVTPLQQMLASCTGAILTSVIVTPLDVVKIRLQAQNNPLPKGKCFVYSNGLMDHL 66

  Fly    91 CPCGPDTPNPAAAKPAPRFSGTIDAFIKISRTEGIGSLWSGLSPTLISALPSTIIYFVAYEQFKA 155
            |.| .:..|....|....|.||:|||.||.|.|||.||||||.|||:.|:|:|:|||..|:|..|
Human    67 CVC-EEGGNKLWYKKPGNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLSA 130

  Fly   156 RFTDIHYKYTRRPDTIAHDIPHPIPFLVPLLAGVSGRILAVTCVSPVELIRTKMQSQRMTHAEMF 220
            .   :..|.......|            |::||:..|..|||.:||:|||||||||::.::.|:.
Human   131 L---LRSKLGENETCI------------PIVAGIVARFGAVTVISPLELIRTKMQSKKFSYVELH 180

  Fly   221 GTIRQVVQSQGVLGLWRGLPPTILRDVPFSGIYWTCYEYLK----SSFGVVEPTFSFSFAAGAIS 281
            ..:.:.|...|.:.||||..||:|||||||.:||..||.||    ...|:.||||..:|.:||:|
Human   181 RFVSKKVSEDGWISLWRGWAPTVLRDVPFSAMYWYNYEILKKWLCEKSGLYEPTFMINFTSGALS 245

  Fly   282 GSVAATITTPFDVVKTHEQIEFGEKFIFSDNPPKQVATKSVAMRLASIYRMGGVPAIFSGLGPRL 346
            ||.||..|.|||||||.:|.:.........:.|..::|..:   :.:|....|...:||||.|||
Human   246 GSFAAVATLPFDVVKTQKQTQLWTYESHKISMPLHMSTWII---MKNIVAKNGFSGLFSGLIPRL 307

  Fly   347 FKVAPACAIMISSFEYGKSFFYHYNI 372
            .|:|||||||||::|:||:||...|:
Human   308 IKIAPACAIMISTYEFGKAFFQKQNV 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawn	NP_001027071.1	Mito_carr	39..159	CDD:278578	65/119 (55%)
		Mito_carr	178..265	CDD:278578	40/90 (44%)
		Mito_carr	268..371	CDD:278578	47/102 (46%)
SLC25A40	NP_061331.2	Mito_carr	12..136	CDD:278578	65/127 (51%)
		Solcar 1	13..131		64/118 (54%)
		Solcar 2	139..223		41/95 (43%)
		Mito_carr	145..228	CDD:278578	39/82 (48%)
		Mito_carr	231..330	CDD:278578	47/101 (47%)
		Solcar 3	233..327		44/96 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4896
eggNOG	1	0.900	-	-		E1_KOG0761
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6040
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2798
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53824
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001594
OrthoInspector	1	1.000	-	-		mtm8620
orthoMCL	1	0.900	-	-		OOG6_101405
Panther	1	1.100	-	-	LDO	PTHR45760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2199
SonicParanoid	1	1.000	-	-		X1001
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.860