DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shawn and aralar1

DIOPT Version :9

Sequence 1:	NP_001027071.1	Gene:	Shawn / 3772641	FlyBaseID:	FBgn0031039	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001247368.1	Gene:	aralar1 / 43616	FlyBaseID:	FBgn0028646	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	347	Identity:	83/347 - (23%)
Similarity:	135/347 - (38%)	Gaps:	110/347 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VTACFMTPLDVIKTRLQAQQQALLSNKCFLYCNGLMDHICPCGPDTPNPAAAKPAPRFSGTI--- 113
            |.|..:.|:|::|||:|.|:                                  |..:.|.:
  Fly   367 VGATVVYPIDLVKTRMQNQR----------------------------------AGSYIGEVAYR 397

  Fly   114 ---DAFIKISRTEGIGSLWSGLSPTLISALPSTIIYFVAYEQFKARFTDIHYKYTRRPDTIAHDI 175
               |.|.|:.|.||...|:.||.|.|:...|...|.....:..:.:.||      ::.:
  Fly   398 NSWDCFKKVVRHEGFMGLYRGLLPQLMGVAPEKAIKLTVNDLVRDKLTD------KKGN------ 450

  Fly   176 PHPIPFLVPLLAGVSGRILAVTCVSPVELIRTKMQSQRMTHAEMFGTIR--------QVVQSQGV 232
               ||....:|||.......|...:|:|:::.::|        :.|.|.        .||:..|:
  Fly   451 ---IPTWAEVLAGGCAGASQVVFTNPLEIVKIRLQ--------VAGEIASGSKIRAWSVVRELGL 504

  Fly   233 LGLWRGLPPTILRDVPFSGIYWTCYEYLKSSF----GVVEPTFSFSFAAGAISGSVAATITTPFD 293
            .||::|....:|||||||.||:..|.:.|:..    |...|.  ...|||||:|..||::.||.|
  Fly   505 FGLYKGARACLLRDVPFSAIYFPTYAHTKAMMADKDGYNHPL--TLLAAGAIAGVPAASLVTPAD 567

  Fly   294 VVKTHEQI--EFGE----------KFIFSDNPPKQVATKSVAMRLASIYRMGGVPAIFSGLGPRL 346
            |:||..|:  ..|:          |.|.::..|:                     |.:.|...|:
  Fly   568 VIKTRLQVVARSGQTTYTGVWDATKKIMAEEGPR---------------------AFWKGTAARV 611

  Fly   347 FKVAPACAIMISSFEYGKSFFY 368
            |:.:|...:.:.::|..:..||
  Fly   612 FRSSPQFGVTLVTYELLQRLFY 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawn	NP_001027071.1	Mito_carr	39..159	CDD:278578	24/112 (21%)
		Mito_carr	178..265	CDD:278578	28/98 (29%)
		Mito_carr	268..371	CDD:278578	28/113 (25%)
aralar1	NP_001247368.1	EF-hand_7	35..99	CDD:290234
		EF-hand_8	51..99	CDD:290545
		EF-hand_7	81..134	CDD:290234
		EFh	84..135	CDD:298682
		EF-hand_7	111..173	CDD:290234
		Mito_carr	350..448	CDD:278578	26/120 (22%)
		PTZ00169	358..631	CDD:240302	81/343 (24%)
		Mito_carr	449..539	CDD:278578	28/106 (26%)
		Mito_carr	544..633	CDD:278578	26/111 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45441470
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840