Protein Alignment His2A:CG33832 and H2AZ1

DIOPT Version :10

• Sequence 1: NP_001027331.1
• Gene: His2A:CG33832 / 3772632
• FlyBaseID: FBgn0053832
• Length: 124
• Species: Drosophila melanogaster
• Sequence 2: NP_002097.1
• Gene: H2AZ1 / 3015
• HGNCID: 4741
• Length: 128
• Species: Homo sapiens
• Alignment Length: 128
• Identity: 79/128 - (61%)
• Similarity: 93/128 - (72%)
• Gaps: 7/128 - (5%)

  Fly     1 MSGRGKGGKVKGKAK----SRSNRAGLQFPVGRIHRLLRKGNYAE-RVGAGAPVYLAAVMEYLAA 60
            |:| ||.||..||||    |||.|||||||||||||.|:....:. ||||.|.||.||::|||.|
Human     1 MAG-GKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTA 64

  Fly    61 EVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTEKK 123
            |||||||||::|.|..||.|||||||||.||||:.|:. .|||.|||:|:|...|:.||.::|
Human    65 EVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIK-ATIAGGGVIPHIHKSLIGKKGQQK 126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
His2A:CG33832	NP_001027331.1	PTZ00017	16..124	CDD:185399	69/109 (63%)
H2AZ1	NP_002097.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		14/24 (58%)
		Required for interaction with INCENP. /evidence=ECO:0000250	1..17		10/16 (63%)
		PLN00154	6..121	CDD:177756	72/115 (63%)
		M6 cassette	89..100		8/10 (80%)
		Required for interaction with INCENP. /evidence=ECO:0000250	93..103		5/10 (50%)
		Required for interaction with PWWP2A. /evidence=ECO:0000269|PubMed:28645917	120..128		3/7 (43%)