Protein Alignment His3:CG33848 and CENPA

DIOPT Version :10

• Sequence 1: NP_001027358.1
• Gene: His3:CG33848 / 3772619
• FlyBaseID: FBgn0053848
• Length: 136
• Species: Drosophila melanogaster
• Sequence 2: NP_001800.1
• Gene: CENPA / 1058
• HGNCID: 1851
• Length: 140
• Species: Homo sapiens
• Alignment Length: 132
• Identity: 67/132 - (50%)
• Similarity: 84/132 - (63%)
• Gaps: 9/132 - (6%)

  Fly     9 RKSTGGKAPRKQ----LATKAARKSAPATGGVKKPH-RYRPGTVALREIRRYQKSTELLIRKLPF 68
            |:|...:|||::    ..|....:..|:.|.....| |.|.|.  |:|||:.||||.||||||||
Human     5 RRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGW--LKEIRKLQKSTHLLIRKLPF 67

  Fly    69 QRLVREIAQDFK--TDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRI 131
            .||.|||...|.  .|..:|:.|::|||||:||:||.||||..|..:||.|||:.|||:||||||
Human    68 SRLAREICVKFTRGVDFNWQAQALLALQEAAEAFLVHLFEDAYLLTLHAGRVTLFPKDVQLARRI 132

  Fly   132 RG 133
            ||
Human   133 RG 134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
His3:CG33848	NP_001027358.1	PTZ00018	1..136	CDD:185400	67/132 (51%)
CENPA	NP_001800.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		11/40 (28%)
		H3	34..137	CDD:128705	60/103 (58%)
		Important for flexibility of DNA ends that protrude from nucleosomes. /evidence=ECO:0000269|PubMed:27499292	39..54		8/16 (50%)
		CATD. /evidence=ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:7962047	75..116		18/40 (45%)