DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gr59f and VARS1

DIOPT Version :9

Sequence 1:	NP_788432.1	Gene:	Gr59f / 37726	FlyBaseID:	FBgn0041234	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	XP_005249419.1	Gene:	VARS1 / 7407	HGNCID:	12651	Length:	1265	Species:	Homo sapiens

Alignment Length:	273	Identity:	55/273 - (20%)
Similarity:	92/273 - (33%)	Gaps:	80/273 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NPQ---YAERYKELYRTLF---WLLLISVLANTAPITILPG----CPNRFYRLVHLSWM------ 71
            ||.   ...|.|::...|.   |.:....:|..|...:..|    .|....|..| :||
Human   657 NPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWH-AWMDNIREW 720

  Fly    72 ----ILWYG-----LFVL-------------GSYW---------------EFVLVTTQRVSLDRY 99
                .||:|     .||.             |.||               ||. |:..::||.:.
Human   721 CISRQLWWGHRIPAYFVTVSDPAVPPGEDPDGRYWVSGRNEAEAREKAAKEFG-VSPDKISLQQD 784

  Fly   100 LNAIESAIYVVHIFSIMLLTWQCRNWAPKLMTNIVTSDLNRAYTIDCNRTKRFIRLQLFLVGIFA 164
            .:.::: .:...:|.:.:|.|.  |.:..|......:.|...:.|......|.:.|.|.|.|...
Human   785 EDVLDT-WFSSGLFPLSILGWP--NQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGRLP 846

  Fly   165 CLAIFFNIWTHKFV--VYRSILSINSYVMPNIISSISFAQYYLLLQGIAWRQRRLTEGLERELTH 227
                |..::.|..|  .:...:|.:   :.|:|..:... |.:.|||:  ..:.|...|:.
Human   847 ----FREVYLHAIVRDAHGRKMSKS---LGNVIDPLDVI-YGISLQGL--HNQLLNSNLDP---- 897

  Fly   228 LHSPRISEVQKIR 240
                  |||:|.:
Human   898 ------SEVEKAK 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gr59f	NP_788432.1	7tm_7	61..388	CDD:303125	45/225 (20%)
VARS1	XP_005249419.1	GstA	<56..203	CDD:223698
		GST_C_ValRS_N	92..213	CDD:198327
		PTZ00419	283..1265	CDD:240411	55/273 (20%)
		ValRS_core	336..939	CDD:185677	55/273 (20%)
		tRNA-synt_1_2	514..>610	CDD:290334
		Anticodon_Ia_Val	939..1076	CDD:153416
		Val_tRNA-synt_C	1197..1259	CDD:287436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900