Protein Alignment Gr59f and MARS1

DIOPT Version :10

• Sequence 1: NP_788432.1
• Gene: Gr59f / 37726
• FlyBaseID: FBgn0041234
• Length: 406
• Species: Drosophila melanogaster
• Sequence 2: NP_004981.2
• Gene: MARS1 / 4141
• HGNCID: 6898
• Length: 900
• Species: Homo sapiens
• Alignment Length: 1097
• Identity: 186/1097 - (16%)
• Similarity: 310/1097 - (28%)
• Gaps: 424/1097 - (38%)

  Fly   115 PEWALSLQTVQH--VSH-ALVSVEQEFEFVITLGSEVARFNA----------------------- 153
            ||...:||.::|  ||| .|.::..|...:.:|.:.|||.|:
Human    49 PEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSH 113

  Fly   154 -NTWECMQEWVEC-------------------LRSKLREMKLLSPKENLYSRLPEVRPPLAPTRD 198
             ...||.:|....                   |...|.::..|...||....||.....|...:
Human   114 NQLTECPRELENAKNMLVLNLSHNSIDSIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQ- 177

  Fly   199 PTSPLPATPPVPAAIVPGIERVQPPSLVQQQHHGHHASVGASASGQSSSLSTAGASGSAGASSSM 263
             |..|...|.:.|.:     |..|..:..|..|
Human   178 -TLVLNGNPLLHAQL-----RQLPAMMALQTLH-------------------------------- 204

  Fly   264 VSNT-GTTSSISSSVSSSSSSSSSSSSSSSSSSSSSGTSYSSTLTSISNCPVTGERGSAAGPPAM 327
            :.|| .|.|::.:|:...|:.|....|.:.             ||.:..|..|           :
Human   205 LRNTQRTQSNLPTSLEGLSNLSDVDLSCND-------------LTRVPECLYT-----------L 245

  Fly   328 SNTSTQNL--------------------MNLLSNPLQAVSSINAQSSKIQPASVTDS-------- 364
            .|....||                    :||..|.|.::.|...:.:|::...:..:
Human   246 PNLHRLNLSSNQIAELSLCIDQWVHLETLNLSRNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLP 310

  Fly   365 VSLGSTSSLVSEEEPQPLEESQSCTASTSPSRDSASGSSLPKPQKIINRDNTTTGHHNHHPLVTL 429
            ..:|..:|         |||..:  |:.:......|....||.:|::         .|.:.||||
Human   311 SGIGKLTS---------LEEFMA--ANNNLELIPESLCRCPKLRKLV---------LNKNRLVTL 355

  Fly   430 AAGTSTTTSSLATTFVTNVLADPSGTAGPSLKRAINDKKLLLDVRQSPE--------RSTTASCD 486
            ..         |..|:|.:                    .:||||::|.        ..|....:
Human   356 PE---------AIHFLTEI--------------------EVLDVRENPSLVMPPKPADHTAEWYN 391

  Fly   487 VD----------EAFDATGNGISNGDHTNDVSPLANAIPL-----SPKSTKEEQVAN--ITIIQV 534
            :|          .|..||....:.|..:.|  |||..:.|     |.:..:.:||..  ..:.|.
Human   392 IDFSLQNQLRLAGASPATVAAAAAGSGSKD--PLARKMRLRRRKDSAQDVQAKQVLKGMSDVAQE 454

  Fly   535 SNSGMVTTPSPTITTASSPKHGASRFNFPKAKPSTMATATVPTNTTTVSTIITDDLGD------- 592
            .|.....:     |.|.:|.....|::....||           ....|...|:|:|.
Human   455 KNKNQEES-----TDARAPGGKVRRWDQGLEKP-----------RLDYSEFFTEDVGQLPGLTIW 503

  Fly   593 ---------------GRNYMSNVQIIPSS-----------------GEYPRNAVQPMQPSIIASI 625
                           |:.|.::..|:..:                 ||              |::
Human   504 QIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGE--------------ATL 554

  Fly   626 NEQQITTVTVPNVQSALSIASTVTSTPRIQPTAPATVQVAVATSSTPIKGPESNFGTV--TQIAV 688
            :::..:.:...|:::.|. |...|:...:...:...:||.....|....|..|.|.||  |....
Human   555 DKKACSAIHAVNLRNYLG-AECRTAREEMGDESEGFLQVFDNDISYIEGGTASGFYTVEDTHYVT 618

  Fly   689 NSSSTAGAVAGSSQPIHFQPSSHPSSSQHYEQVFLTS---SVQVTSGNGQTESNIEEPVIVSPAP 750
            ......|     .:.|..:|.....:|.....|||..   .:.|..|...|.||..:
Human   619 RMYRVYG-----KKNIKLEPVPLKGTSLDPRFVFLLDQGLDIYVWRGAQATLSNTTK-------- 670

  Fly   751 IVAKSSANKSSKVLLLSRQPRSSSHSDIPLPARLGSKGGSRKTEPPGSNDKENRVQHDSIIGSQG 815
              |:..|.|.:|                                    |:::.:.:...::..|
Human   671 --ARLFAEKMNK------------------------------------NERKGKAEITLLVQGQ- 696

  Fly   816 VGSGTASTSKPP-------GSAAATAPAVPTHLTGGSPS-----------KRPAVDRNIYTPHPQ 862
                     :||       |..:.....||.......|.           :.|.::..:...|.:
Human   697 ---------EPPEFWDVLGGEPSEIKKHVPDDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKK 752

  Fly   863 RTAPLLQRG--LTELVLSTRTVASPVPHAID--QSALAARGRRAPVESKVRVDQLAPE-----QR 918
            |....|..|  |.:.:|.||.|     :.:|  .......||::|...:....:|..|     .|
Human   753 RPKVELMPGMRLLQSLLDTRCV-----YILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHR 812

  Fly   919 RRSSSTSDARQDASSGP------------RVNGSAGAAPGAAGPGMGPGRL-------------- 957
            .|.:..|.:.:...:..            .|:.:..|.....|||:. |::
Human   813 PRHTVVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQGPGIS-GKVKRDTEKKDQMKADL 876

  Fly   958 ------QSPPQPFRPHHQLINVPEGSQLIGANGLVAHGTPASAAGNRKLTLREQQVF 1008
                  :.||.|.....||:. .....|.|..|.|..|        ||.|...::.|
Human   877 TALFLPRQPPMPLAEAEQLME-EWNEDLDGMEGFVLEG--------RKFTRLAEEEF 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gr59f	NP_788432.1	7tm_7	61..388	CDD:473258	60/347 (17%)
MARS1	NP_004981.2	GST_N_5	1..74	CDD:436537	9/24 (38%)
		GST_C_MetRS_N	77..179	CDD:198340	16/103 (16%)
		PLN02610	251..893	CDD:215329	128/790 (16%)
		'HIGH' region	273..283		4/9 (44%)
		'KMSKS' region	593..597		0/3 (0%)