DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp22 and HSPB8

DIOPT Version :9

Sequence 1:	NP_001027114.1	Gene:	Hsp22 / 3772576	FlyBaseID:	FBgn0001223	Length:	174	Species:	Drosophila melanogaster
Sequence 2:	NP_055180.1	Gene:	HSPB8 / 26353	HGNCID:	30171	Length:	196	Species:	Homo sapiens

Alignment Length:	136	Identity:	43/136 - (31%)
Similarity:	65/136 - (47%)	Gaps:	28/136 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 MPRLSSPFHAFFHEPPVW-----SVALPRNWQQIARW---QEQEFAPPATVNKDGYKLTLDVKDY 73
            :|||||          .|     |..:||.....||:   .|....||  ...:.:|:.::|..:
Human    53 LPRLSS----------AWPGTLRSGMVPRGPTATARFGVPAEGRTPPP--FPGEPWKVCVNVHSF 105

  Fly    74 --SELKVKVLDESVVLVEGKSEQQEAEQGGYSSRHFLRRFVLPEGYEADKVT--STLSSDGVLTI 134
              .||.||..| ..|.|.||.|::: ::||..|::|.::..||.  |.|.||  ::||.:|:|.|
Human   106 KPEELMVKTKD-GYVEVSGKHEEKQ-QEGGIVSKNFTKKIQLPA--EVDPVTVFASLSPEGLLII 166

  Fly   135 SVPNPP 140
            ..|..|
Human   167 EAPQVP 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp22	NP_001027114.1	IbpA	17..154	CDD:223149	43/136 (32%)
Hsp22	NP_001027114.1	metazoan_ACD	61..138	CDD:107247	27/80 (34%)
HSPB8	NP_055180.1	ACD_HspB8_like	80..170	CDD:107235	30/95 (32%)
HSPB8	NP_055180.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..196
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148940
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700