DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp22 and Hspb6

DIOPT Version :9

Sequence 1:	NP_001027114.1	Gene:	Hsp22 / 3772576	FlyBaseID:	FBgn0001223	Length:	174	Species:	Drosophila melanogaster
Sequence 2:	NP_001012401.1	Gene:	Hspb6 / 243912	MGIID:	2685325	Length:	162	Species:	Mus musculus

Alignment Length:	146	Identity:	48/146 - (32%)
Similarity:	70/146 - (47%)	Gaps:	36/146 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AEEMARMPRLSSPFHAFFHEPPVWSVALPRNWQQIARWQEQEFAPPATVNKD-GY-KLTLDVKDY 73
            ||..:..|...:|:  :...|   ||||                |.|.|:.| || .:.||||.:
Mouse    40 AELASLCPAAIAPY--YLRAP---SVAL----------------PTAQVSTDSGYFSVLLDVKHF 83

  Fly    74 --SELKVKVLDESVVLVEGKSEQQEAEQGGYSSRHFLRRFVLPEGYEADKVTSTLSSDGVLTI-- 134
              .|:.|||:|:.|. |..:.|::..|. |:.:|.|.||:.||.|.:...|||.||.:|||:|
Mouse    84 LPEEISVKVVDDHVE-VHARHEERPDEH-GFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQA 146

  Fly   135 -------SVPNPPGVQ 143
                   .:|:||..:
Mouse   147 TPASAQAQLPSPPAAK 162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp22	NP_001027114.1	IbpA	17..154	CDD:223149	46/140 (33%)
Hsp22	NP_001027114.1	metazoan_ACD	61..138	CDD:107247	33/89 (37%)
Hspb6	NP_001012401.1	Involved in stabilization of the HSPB1:HSBP6 heterodimer. /evidence=ECO:0000250\|UniProtKB:O14558	1..72		13/52 (25%)
		Crystallin	5..56	CDD:278926	4/17 (24%)
		ACD_HspB4-5-6	66..148	CDD:107233	34/83 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910