DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp22 and CRYAB

DIOPT Version :9

Sequence 1:	NP_001027114.1	Gene:	Hsp22 / 3772576	FlyBaseID:	FBgn0001223	Length:	174	Species:	Drosophila melanogaster
Sequence 2:	NP_001276736.1	Gene:	CRYAB / 1410	HGNCID:	2389	Length:	175	Species:	Homo sapiens

Alignment Length:	163	Identity:	55/163 - (33%)
Similarity:	85/163 - (52%)	Gaps:	27/163 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PFHA-------FFHE--------PPVWSVA----LPRNWQQIARWQEQEFAPPATVNKDGYKLTL 68
            |||:       ||.|        |...|::    .|.::.:...|.:...: ...:.||.:.:.|
Human    16 PFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLS-EMRLEKDRFSVNL 79

  Fly    69 DVKDYS--ELKVKVLDESVVLVEGKSEQQEAEQGGYSSRHFLRRFVLPEGYEADKVTSTLSSDGV 131
            |||.:|  |||||||.: |:.|.||.|:::.|. |:.||.|.|::.:|...:...:||:||||||
Human    80 DVKHFSPEELKVKVLGD-VIEVHGKHEERQDEH-GFISREFHRKYRIPADVDPLTITSSLSSDGV 142

  Fly   132 LTISVPNPPGVQETLKEREVTIEQTGEPAKKSA 164
            ||:   |.|..|.:..||.:.|.:..:||..:|
Human   143 LTV---NGPRKQVSGPERTIPITREEKPAVTAA 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp22	NP_001027114.1	IbpA	17..154	CDD:223149	51/151 (34%)
Hsp22	NP_001027114.1	metazoan_ACD	61..138	CDD:107247	36/78 (46%)
CRYAB	NP_001276736.1	Crystallin	1..52	CDD:395419	8/35 (23%)
		ACD_alphaB-crystallin_HspB5	67..150	CDD:107246	38/87 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..175		9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940