DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp22 and Cryaa

DIOPT Version :9

Sequence 1:	NP_001027114.1	Gene:	Hsp22 / 3772576	FlyBaseID:	FBgn0001223	Length:	174	Species:	Drosophila melanogaster
Sequence 2:	NP_001265498.1	Gene:	Cryaa / 12954	MGIID:	88515	Length:	202	Species:	Mus musculus

Alignment Length:	141	Identity:	43/141 - (30%)
Similarity:	73/141 - (51%)	Gaps:	15/141 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HAFF--HEPPVWSVALPRNWQQIARWQEQEFAPPATVNKDGYKLTLDVKDYS--ELKVKVLDESV 85
            |.:|  |:|...:   |:|....|.:..:     ...::|.:.:.||||.:|  :|.|||| |..
Mouse    67 HMWFVMHQPHAGN---PKNNPVKASYMAK-----VRSDRDKFVIFLDVKHFSPEDLTVKVL-EDF 122

  Fly    86 VLVEGKSEQQEAEQGGYSSRHFLRRFVLPEGYEADKVTSTLSSDGVLTISVPN-PPGVQETLKER 149
            |.:.||..::: :..||.||.|.||:.||...:...::.:||:||:||.|.|. ..|:.....||
Mouse   123 VEIHGKHNERQ-DDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVQSGLDAGHSER 186

  Fly   150 EVTIEQTGEPA 160
            .:.:.:..:|:
Mouse   187 AIPVSREEKPS 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp22	NP_001027114.1	IbpA	17..154	CDD:223149	42/133 (32%)
Hsp22	NP_001027114.1	metazoan_ACD	61..138	CDD:107247	31/78 (40%)
Cryaa	NP_001265498.1	Crystallin	1..50	CDD:278926
		alpha-crystallin-Hsps_p23-like	90..174	CDD:294116	31/90 (34%)
		IbpA	<93..174	CDD:223149	31/82 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840