Protein Alignment His2B:CG33884 and H2BC7

DIOPT Version :10

• Sequence 1: NP_001027345.1
• Gene: His2B:CG33884 / 3772575
• FlyBaseID: FBgn0053884
• Length: 123
• Species: Drosophila melanogaster
• Sequence 2: NP_003513.1
• Gene: H2BC7 / 8343
• HGNCID: 4752
• Length: 126
• Species: Homo sapiens
• Alignment Length: 904
• Identity: 167/904 - (18%)
• Similarity: 276/904 - (30%)
• Gaps: 352/904 - (38%)

  Fly     3 LSPLSFSTSSSFSHAD-GIDDGVELISSP------------------FAGGAMLPVFLNDLSRNS 48
            ||.||.:..||....: ....|:.|:.||                  .....:.|..:...|.|:
Human   644 LSMLSLTYHSSIRSLEVQCGAGLTLLWSPPDHMYLYQHVRATLQCRDLLRATVFPEIIESHSLNT 708

  Fly    49 GESGSGSSWE-----------RELVEVTLELD-------VGDDSILVCGMSEAASVDSRARSVDL 95
            .:    |:||           |.|:.:|||:.       |.:|..:... :|:.|::....|:..
Human   709 PQ----STWEPEDHLPESSLPRRLLTLTLEVSTAKLTAFVAEDKFITLA-AESVSLNRHGGSLQA 768

  Fly    96 VTARLSR--------NLSNASTRIRQKLGKL------------LRSESWKTTTSSTAGE--RDRD 138
            ....|:.        ||.....::..:|.::            ||:..|..:..|.:.|  ...|
Human   769 YCPELAAGFDGNSIFNLKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSLGSVSVEFPYQYD 833

  Fly   139 LERQTAVTLGILTARDKRKEDAKLQRSTSSAQRALKGLQFINKTTRGNSCVCDWDCDCDQMWKKV 203
            ..|.....:|:                    |:.||||.      ||.           ..|...
Human   834 FSRTLDEAVGV--------------------QKWLKGLH------RGT-----------HAWASP 861

  Fly   204 EKRFESLSKNGLLARDDFGECVGMVDSKDFAVSVFDALARRRRQKLEKITKDELHDFWLQISDQS 268
            ..  ..|..:.||....|.             .||          |:.|.:.:|||.:..:.|:|
Human   862 SP--APLPPDLLLKVQHFS-------------WVF----------LDDIFEVKLHDNYELMKDES 901

  Fly   269 FDA--RLQIFFDMADSNEDGKIT--REEIKELLMLSASANKLAKLKEQAEEYASLIMEELDPENF 329
            .::  |||:.        |.|:.  |::..|||    .|.|:.:|      ||||..:.::
Human   902 KESAKRLQLL--------DAKVAALRKQHGELL----PARKIEEL------YASLERKNIE---- 944

  Fly   330 GYIELWQLETLLLQRDAYMNYSRPLSTTSGGVSTPRRNLIR------------------PRHVVQ 376
                      :.:||...:..:.|:          ||.|:.                  |.||::
Human   945 ----------IYIQRSRRLYGNTPM----------RRALLTWSLAGLELVALADASFHGPEHVIE 989

  Fly   377 KCRKKLQCLILD--------------NWQRSWVLLVWVMLMAILFVWKFL-EYREKAAFKVMGYC 426
            :.|:      ||              .|.|.....|...|:.|....::| |.|:   :::||..
Human   990 QVRE------LDPGSPFPAEGMDLVTQWCRMLKCNVKTFLVRIRDYPRYLFEIRD---WRLMGRL 1045

  Fly   427 LTTAKGAAETLKLNMALVLLPVCRNTLTWLRSTRARACVPFDDNINFH-KIIACAIAIG------ 484
            ..|.:......:....|.|      .|.|......|...|.....:|| :|....:..|
Human  1046 AGTEQSGQPCSRRRQILHL------GLPWGNVAVERNMPPLKFYHDFHSEIFQYTVVWGPCWDPA 1104

  Fly   485 -----------------------------ILVHAGTH----------LACDFPRIINSS------ 504
                                         :|.|...|          ||.:.|  .|::
Human  1105 WTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQLATEDP--YNTTENMHWE 1167

  Fly   505 ---------PEQFVLIASAFNGTKPTFKDL---MTGAEGITGISMVILTTIAFTL-------AST 550
                     |.|||     |.|      ||   :..|........:.|..:..||       .:.
Human  1168 WSHLSFHWKPGQFV-----FRG------DLDVNVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNP 1221

  Fly   551 HFRRN-RVRLP-----APLDRL-TGFNAFW-----------YTHHLLVVVYIMLIVHGTFLFFAD 597
            |...: .:|.|     .||.:| ..:.||.           .|.|...:....::|:.:.|
Human  1222 HDHHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILVYSSTL---- 1282

  Fly   598 KWYQK--TTWMYISVPLVLYVAERSLRACRSK---HYSVKILKVSMLP----------GEVLSLI 647
            :|.|.  .||..|:.|:.......:|:..:.|   ||. ::...::.|          .:...:.
Human  1283 RWMQNFWATWTSITRPICRGKLFNNLKPSKKKLGQHYK-QLSYTALFPQLQVHYWASFAQQRGIQ 1346

  Fly   648 MSKPPGFKYKSG-QYIFLQCPTISR---FEWHPFSITSAPGD-DQLSVHIRTLGDWTEE 701
            :....|..:..| |.:..|..|:.|   .||   |:|....| .|::||:  :...|||
Human  1347 IECSQGHVFTRGTQRLIPQAGTVMRRLISEW---SVTQMVSDLSQVTVHL--MASPTEE 1400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
His2B:CG33884	NP_001027345.1	HFD_H2B	33..120	CDD:467035	20/124 (16%)
H2BC7	NP_003513.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		HFD_H2B	30..123	CDD:467035