DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fuca and Fuca1

DIOPT Version :9

Sequence 1:	NP_001303363.1	Gene:	Fuca / 3772574	FlyBaseID:	FBgn0285958	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_077205.3	Gene:	Fuca1 / 71665	MGIID:	95593	Length:	452	Species:	Mus musculus

Alignment Length:	490	Identity:	221/490 - (45%)
Similarity:	307/490 - (62%)	Gaps:	47/490 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLVALIVVWISAAEVDAQVPGPRTRYQPNWASLDQRPLPQWYDDAKVGIFLHYGVYSVPSFGSEW 73
            :|:.|:::.::||:..|..|   .|:.|:|.|||.||||.|:|:||.|:|:|:||:|||::||||
Mouse     1 MLLLLLLLLVAAAQAVALAP---RRFTPDWQSLDSRPLPSWFDEAKFGVFVHWGVFSVPAWGSEW 62

  Fly    74 FWTNWKNLRNPEYVQFMQRNYKPDFTYQEFASQFTAELFNATKWALLFKDSGARYVVLTSKHHDG 138
            ||.:|:..|.|.|.:||..||.|.|:|.:||.||||..|:..:||.||:.:||:|||||:|||:|
Mouse    63 FWWHWQGDRMPAYQRFMTENYPPGFSYADFAPQFTARFFHPDQWAELFQAAGAKYVVLTTKHHEG 127

  Fly   139 FTLWPSKNSYGWNSMDVGPKRDIVKELAAAIRKESDLRFGLYYSLFEWFNPLWTDDKLHLLMQQH 203
            ||.|||..|:.|||.||||.||:|.||.||:||. ::|:|||:||.|||:||:..||.:....||
Mouse   128 FTNWPSPVSWNWNSKDVGPHRDLVGELGAAVRKR-NIRYGLYHSLLEWFHPLYLLDKKNGFKTQH 191

  Fly   204 FVERKVRPEQMELVQQYLPEIIWSDGDWEAPAKYWRSEEFIAWLYNDSPVRDTVVTNDRWGFGTA 268
            ||..|..||..:||..|.|::|||||:||.|..||.|..|:|||||||||:|.|:.|||||...:
Mouse   192 FVRAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTSFLAWLYNDSPVKDEVIVNDRWGQNCS 256

  Fly   269 CMHGDFYNCADRFNPGVLQAHKWENAFTLDRTSWGQRFDVSLSDFMTSKEVIKEIITTVSCNGNV 333
            |.||.:|||.|::.|..|..||||...::||.|||.|.|:::|......|:|:|::.|||..||.
Mouse   257 CHHGGYYNCQDKYKPQSLPDHKWEMCTSMDRASWGYRKDMTMSTIAKENEIIEELVQTVSLGGNY 321

  Fly   334 LINVGPTKFGTILPIFEERLRDMGRWLKFNGEGIYGSVPWIYQNDTINGNVWYTRQKEASNGKIT 398
            |:|:||||.|.|:|||:|||..:|:||:.|||.||.|.||..|::.....||||.:      ..|
Mouse   322 LLNIGPTKDGLIVPIFQERLLAVGKWLQINGEAIYASKPWRVQSEKNKTVVWYTTK------NAT 380

  Fly   399 IYAFVLEYPYDTNELDIYPLGKDINIFRNVMLTGIDMGTGGDILNEQS------TEVVMLGMEDT 457
            :||..|.:|.:                              .|:|.:|      |::.|||:|.
Mouse   381 VYATFLYWPEN------------------------------GIVNLKSPKTTSATKITMLGLEG- 414

  Fly   458 KIKWNADHNRLHIVFPPKNHIDKRGLDYAWTFKIT 492
            .:.|..|.....::..|:.......:::|||.|:|
Mouse   415 DLSWTQDPLEGVLISLPQLPPTVLPVEFAWTLKLT 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fuca	NP_001303363.1	Alpha_L_fucos	28..409	CDD:214829	200/380 (53%)
		AfuC	60..>373	CDD:226195	171/312 (55%)
		Fucosidase_C	376..492	CDD:293362	25/121 (21%)
Fuca1	NP_077205.3	Alpha_L_fucos	20..399	CDD:214829	202/418 (48%)
		AfuC	49..>367	CDD:226195	174/318 (55%)
		Fucosidase_C	372..449	CDD:293362	24/113 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839846
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3669
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1464
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62607
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002668
OrthoInspector	1	1.000	-	-		otm44119
orthoMCL	1	0.900	-	-		OOG6_102401
Panther	1	1.100	-	-	O	PTHR10030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2531
SonicParanoid	1	1.000	-	-		X1781
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790