DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fuca and fuca1.2

DIOPT Version :9

Sequence 1:	NP_001303363.1	Gene:	Fuca / 3772574	FlyBaseID:	FBgn0285958	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001003559.1	Gene:	fuca1.2 / 445165	ZFINID:	ZDB-GENE-040801-78	Length:	451	Species:	Danio rerio

Alignment Length:	488	Identity:	224/488 - (45%)
Similarity:	291/488 - (59%)	Gaps:	55/488 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VALIVVWISAAEVDAQVPGPRTRYQPNWASLDQRPLPQWYDDAKVGIFLHYGVYSVPSFGSEWFW 75
            ::|.:..:|.|.|..      .||.|:|.|||.||||.|||:.|.|||:|:||:|||:|||||||
Zfish     8 ISLFLCLLSCASVIG------ARYTPDWTSLDSRPLPGWYDEVKFGIFVHWGVFSVPAFGSEWFW 66

  Fly    76 TNWKNLRNPEYVQFMQRNYKPDFTYQEFASQFTAELFNATKWALLFKDSGARYVVLTSKHHDGFT 140
            .|||...:.:|:.:|.:||.|.|:|.:||..|.|:.|:...||.:|:.|||:|||||||||:|||
Zfish    67 WNWKGAHDFKYILYMVKNYPPGFSYADFAPDFHAQFFDPDAWAEIFEASGAKYVVLTSKHHEGFT 131

  Fly   141 LWPSKNSYGWNSMDVGPKRDIVKELAAAIRKESDLRFGLYYSLFEWFNPLWTDDKLHLLMQQHFV 205
            .|.|..|:.|||:|.||.||:|.:|..|:||.| |.:|||:||:||||||:..||......|.:|
Zfish   132 NWESPTSWNWNSVDNGPHRDLVGDLGNAVRKRS-LHYGLYHSLYEWFNPLYLSDKQSGFKTQEYV 195

  Fly   206 ERKVRPEQMELVQQYLPEIIWSDGDWEAPAKYWRSEEFIAWLYNDSPVRDTVVTNDRWGFGTACM 270
            .||..||..:||.:|.|::||||||||||..||.|.||:|||||||||:|.||.|||||.|..|.
Zfish   196 ARKAMPELYDLVNRYKPDLIWSDGDWEAPDTYWNSTEFLAWLYNDSPVKDIVVVNDRWGNGCYCK 260

  Fly   271 HGDFYNCADRFNPGVLQAHKWENAFTLDRTSWGQRFDVSLSDFMTSKEVIKEIITTVSCNGNVLI 335
            ||.:|||||:|:||.|..||||...::|..|||.|.::.||:.|....:||:::.||:..||.|:
Zfish   261 HGGYYNCADKFSPGELPKHKWEKCQSVDTISWGYRRNMKLSELMDLPALIKDLVYTVALGGNYLL 325

  Fly   336 NVGPTKFGTILPIFEERLRDMGRWLKFNGEGIYGSVPWIYQNDTINGNVWYTRQKEASNGKITIY 400
            |||||..|.|.|:||||||.:|.||:.|||.||.:..|..|.:.....||||.:..      |:|
Zfish   326 NVGPTADGVIAPVFEERLRGIGAWLQINGEAIYATSSWRVQAENATVPVWYTSKNS------TVY 384

  Fly   401 AFVLEYP-YDTNELDIYPLGKDINIFRNVMLTGIDMGTGGDILNEQSTEVVMLGMEDTKIKWNAD 464
            |.....| .:|.||.. |...|                        :|.|.:|| ....:||...
Zfish   385 AIFTSSPNQNTFELSA-PKTSD------------------------NTVVTLLG-NPKPLKWAPL 423

  Fly   465 HNRLHIV------FPPKNHIDKRGLDYAWTFKI 491
            |:...|:      |.|..         |||.|:
Zfish   424 HSSGLILLLPDLPFSPAQ---------AWTLKL 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fuca	NP_001303363.1	Alpha_L_fucos	28..409	CDD:214829	201/381 (53%)
		AfuC	60..>373	CDD:226195	173/312 (55%)
		Fucosidase_C	376..492	CDD:293362	28/123 (23%)
fuca1.2	NP_001003559.1	Alpha_L_fucos	23..401	CDD:214829	204/385 (53%)
		AfuC	51..>371	CDD:226195	175/320 (55%)
		Fucosidase_C	366..448	CDD:293362	28/123 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583938
Domainoid	1	1.000	449	1.000	Domainoid score	I492
eggNOG	1	0.900	-	-		E1_COG3669
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1408
OMA	1	1.010	-	-		QHG62607
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002668
OrthoInspector	1	1.000	-	-		otm26276
orthoMCL	1	0.900	-	-		OOG6_102401
Panther	1	1.100	-	-	O	PTHR10030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2531
SonicParanoid	1	1.000	-	-		X1781
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790