DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fuca and fuca1.1

DIOPT Version :9

Sequence 1:	NP_001303363.1	Gene:	Fuca / 3772574	FlyBaseID:	FBgn0285958	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_997905.1	Gene:	fuca1.1 / 335494	ZFINID:	ZDB-GENE-030131-7434	Length:	451	Species:	Danio rerio

Alignment Length:	495	Identity:	228/495 - (46%)
Similarity:	297/495 - (60%)	Gaps:	61/495 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ISAWMPLLVALIVVWISAAEVDAQVPGPRTRYQPNWASLDQRPLPQWYDDAKVGIFLHYGVYSVP 67
            ||.::.||..:.|:              ..||.|:|.|||.||||.|||:.|.|||:|:||:|||
Zfish     8 ISLFLCLLSCVSVI--------------GARYTPDWTSLDSRPLPGWYDEVKFGIFVHWGVFSVP 58

  Fly    68 SFGSEWFWTNWKNLRNPEYVQFMQRNYKPDFTYQEFASQFTAELFNATKWALLFKDSGARYVVLT 132
            :|||||||..||..:||:|||||.:||.|.|:|.:||..|.|:.|:...||.:|:.|||:|||||
Zfish    59 AFGSEWFWWYWKGAQNPDYVQFMIKNYPPGFSYADFAPNFHAQFFDPDAWADIFEASGAKYVVLT 123

  Fly   133 SKHHDGFTLWPSKNSYGWNSMDVGPKRDIVKELAAAIRKESDLRFGLYYSLFEWFNPLWTDDKLH 197
            ||||:|||.|.|..|:.|||:|.||.||:|.:|..||||:. |.:|||:||:||||||:..||..
Zfish   124 SKHHEGFTNWGSPTSWNWNSVDDGPHRDLVGDLGNAIRKKG-LHYGLYHSLYEWFNPLYLSDKQS 187

  Fly   198 LLMQQHFVERKVRPEQMELVQQYLPEIIWSDGDWEAPAKYWRSEEFIAWLYNDSPVRDTVVTNDR 262
            ....|.:|.||..||..:||.:|.|::||||||||||..||.|.||:|||||||||:|.||.|||
Zfish   188 GFKTQEYVARKAMPELYDLVSRYKPDLIWSDGDWEAPDTYWNSTEFLAWLYNDSPVKDIVVVNDR 252

  Fly   263 WGFGTACMHGDFYNCADRFNPGVLQAHKWENAFTLDRTSWGQRFDVSLSDFMTSKEVIKEIITTV 327
            ||.|..|.||.:|||||:|||..|..||||...::|:.|||.|.::.||:.|...|::::::..|
Zfish   253 WGNGCYCKHGGYYNCADKFNPQKLLNHKWEKCQSVDKISWGYRRNMKLSELMDLPELVQDLVYIV 317

  Fly   328 SCNGNVLINVGPTKFGTILPIFEERLRDMGRWLKFNGEGIYGSVPWIYQNDTINGNVWYTRQKEA 392
            :..||.|::.|||..|.|.|:||||||.:|.||:.|||.|||:..|..|.:.....||||.:|.
Zfish   318 ALGGNYLLSTGPTADGVIAPVFEERLRGIGAWLQINGEAIYGTSFWRVQTENATVPVWYTAKKS- 381

  Fly   393 SNGKITIYAFVLEYPYDTNELDIYPLGKDINIFRNVMLTGIDMGTGGDILNEQSTEVVMLGMEDT 457
                 |:||.     :.||.:.        |.|:.......|           ||.|.:|| ...
Zfish   382 -----TVYAI-----FTTNPMQ--------NTFQLSAPNTTD-----------STVVTLLG-SPK 416

  Fly   458 KIKW-NADHNRLHIVFP-----PKNHIDKRGLDYAWTFKI 491
            .:|| ....:.|.:|.|     |.         ||||.|:
Zfish   417 PLKWAPLQSSGLMVVLPELPFSPA---------YAWTLKM 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fuca	NP_001303363.1	Alpha_L_fucos	28..409	CDD:214829	202/380 (53%)
		AfuC	60..>373	CDD:226195	174/312 (56%)
		Fucosidase_C	376..492	CDD:293362	30/122 (25%)
fuca1.1	NP_997905.1	Alpha_L_fucos	23..401	CDD:214829	206/397 (52%)
		AfuC	51..>371	CDD:226195	176/320 (55%)
		Fucosidase_C	366..448	CDD:293362	30/122 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583940
Domainoid	1	1.000	449	1.000	Domainoid score	I492
eggNOG	1	0.900	-	-		E1_COG3669
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1408
OMA	1	1.010	-	-		QHG62607
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002668
OrthoInspector	1	1.000	-	-		otm26276
orthoMCL	1	0.900	-	-		OOG6_102401
Panther	1	1.100	-	-	O	PTHR10030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2531
SonicParanoid	1	1.000	-	-		X1781
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790