DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fuca and FUCA2

DIOPT Version :9

Sequence 1:	NP_001303363.1	Gene:	Fuca / 3772574	FlyBaseID:	FBgn0285958	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_114409.2	Gene:	FUCA2 / 2519	HGNCID:	4008	Length:	467	Species:	Homo sapiens

Alignment Length:	493	Identity:	236/493 - (47%)
Similarity:	314/493 - (63%)	Gaps:	48/493 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PLLVALIVVWISAAEVDAQVPGP------RTRYQPNWASLDQRPLPQWYDDAKVGIFLHYGVYSV 66
            |||:.|:::          :|.|      .||:.|.|.|||.|.||.|:|.||.|||:|:||:||
Human    12 PLLLLLLLL----------LPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIHWGVFSV 66

  Fly    67 PSFGSEWFWTNWKNLRNPEYVQFMQRNYKPDFTYQEFASQFTAELFNATKWALLFKDSGARYVVL 131
            |||||||||..|:..:.|:||:||:.||.|.|.|::|...|||:.|||.:||.:|:.|||:|:||
Human    67 PSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADIFQASGAKYIVL 131

  Fly   132 TSKHHDGFTLWPSKNSYGWNSMDVGPKRDIVKELAAAIRKESDLRFGLYYSLFEWFNPLWTDDKL 196
            |||||:|||||.|:.|:.||::|.||||||||||..|||..:||||||||||||||:||:.:|:.
Human   132 TSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFGLYYSLFEWFHPLFLEDES 196

  Fly   197 HLLMQQHFVERKVRPEQMELVQQYLPEIIWSDGDWEAPAKYWRSEEFIAWLYNDSPVRDTVVTND 261
            ....::.|...|..||..|||..|.||::|||||..||.:||.|..|:|||||:||||.||||||
Human   197 SSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNSTGFLAWLYNESPVRGTVVTND 261

  Fly   262 RWGFGTACMHGDFYNCADRFNPGVLQAHKWENAFTLDRTSWGQRFDVSLSDFMTSKEVIKEIITT 326
            |||.|:.|.||.||.|:||:|||.|..|||||..|:|:.|||.|.:..:||::|.:|::|:::.|
Human   262 RWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKLSWGYRREAGISDYLTIEELVKQLVET 326

  Fly   327 VSCNGNVLINVGPTKFGTILPIFEERLRDMGRWLKFNGEGIYGSVPWIYQNDTINGNVWYT-RQK 390
            |||.||:|:|:|||..|||..:||||||.||.|||.|||.||.:..|..||||:..:|||| :.|
Human   327 VSCGGNLLMNIGPTLDGTISVVFEERLRQMGSWLKVNGEAIYETHTWRSQNDTVTPDVWYTSKPK 391

  Fly   391 EASNGKITIYAFVLEYPYDTNELDIYPLGKDINIFRNVMLTGIDMGTGGDILNEQSTEVVMLGME 455
            |.     .:||..|::|....                     :.:|....||.  :|||.:|| .
Human   392 EK-----LVYAIFLKWPTSGQ---------------------LFLGHPKAILG--ATEVKLLG-H 427

  Fly   456 DTKIKW-NADHNRLHIVFPPKNHIDKRGLDYAWTFKIT 492
            ...:.| :.:.|.:.:..|... |.:....:.|...:|
Human   428 GQPLNWISLEQNGIMVELPQLT-IHQMPCKWGWALALT 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fuca	NP_001303363.1	Alpha_L_fucos	28..409	CDD:214829	218/387 (56%)
		AfuC	60..>373	CDD:226195	184/312 (59%)
		Fucosidase_C	376..492	CDD:293362	27/117 (23%)
FUCA2	NP_114409.2	Alpha_L_fucos	28..413	CDD:214829	217/410 (53%)
		AfuC	60..429	CDD:226195	207/397 (52%)
		Fucosidase_C	376..464	CDD:293362	27/117 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149793
Domainoid	1	1.000	456	1.000	Domainoid score	I499
eggNOG	1	0.900	-	-		E1_COG3669
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H119
Inparanoid	1	1.050	484	1.000	Inparanoid score	I1458
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62607
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002668
OrthoInspector	1	1.000	-	-		otm42065
orthoMCL	1	0.900	-	-		OOG6_102401
Panther	1	1.100	-	-	LDO	PTHR10030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2531
SonicParanoid	1	1.000	-	-		X1781
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.830