DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32269 and PRSS1

DIOPT Version :9

Sequence 1:	NP_001261363.1	Gene:	CG32269 / 3772569	FlyBaseID:	FBgn0052269	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	305	Identity:	98/305 - (32%)
Similarity:	143/305 - (46%)	Gaps:	38/305 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RLRSDNGTKRLTGTKNQTGIRSNRRQGTARKLSAKRVNQNKKAATSSKIQS-------------- 107
            ||..|.|.::..|.....|:.:...|.....:   .|....:::|:|:..|
Human   176 RLMQDPGKRKAAGVFVLGGVVTLTSQSPPLWI---LVRYKDESSTTSQAHSTTMNPLLILTFVAA 237

  Fly   108 ----------RIVGGTSTTISTTPYIVQLRRGSNLCSGSLITEQWVLTAAHCVKGYSASDFTVRG 162
                      :||||.:...::.||.|.|..|.:.|.||||.||||::|.||.|    |...||.
Human   238 ALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYK----SRIQVRL 298

  Fly   163 GTTTLDGSDGVTRSVSSIHVA--PKFTSKKMNMDAALLKL-NQSLTGTNIGTISMGNYRPKAGSR 224
            |...::..:|..:.:::..:.  |::..|.:|.|..|:|| ::::....:.|||:....|..|::
Human   299 GEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTK 363

  Fly   225 VRIAGWGVTKEGSTTASKTLQTAQIRVVRQQKCRKDYRGQATITKYMLCA--RAAGKDSCSGDSG 287
            ..|:|||.|..........||.....|:.|.||...|.|:  ||..|.|.  ...|||||.||||
Human   364 CLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGK--ITSNMFCVGFLEGGKDSCQGDSG 426

  Fly   288 GPVTRNNTLLGIVSFGYGCARAGYPGVYTAVVAIRQWATNIMANN 332
            |||..|..|.|:||:|.|||:...|||||.|....:|..|.:|.|
Human   427 GPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAAN 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32269	NP_001261363.1	Tryp_SPc	108..324	CDD:214473	83/220 (38%)
CG32269	NP_001261363.1	Tryp_SPc	121..324	CDD:238113	79/207 (38%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	83/221 (38%)
		Tryp_SPc	249..467	CDD:238113	84/223 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810