DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32269 and F12

DIOPT Version :9

Sequence 1:	NP_001261363.1	Gene:	CG32269 / 3772569	FlyBaseID:	FBgn0052269	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_000496.2	Gene:	F12 / 2161	HGNCID:	3530	Length:	615	Species:	Homo sapiens

Alignment Length:	288	Identity:	95/288 - (32%)
Similarity:	128/288 - (44%)	Gaps:	37/288 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 KNQTGIRSNRRQGTARKLSAKR-------------VNQNKKAATSSKIQSRIVGGTSTTISTTPY 122
            |.|...|:..:..|...|.|||             ..|..:.:.||  .:|:|||........||
Human   324 KPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSS--MTRVVGGLVALRGAHPY 386

  Fly   123 IVQLRRGSNLCSGSLITEQWVLTAAHCVKGYSA-SDFTVRGGTTTLDGS--DGVTRSVSSIHVAP 184
            |..|..|.:.|:||||...||||||||::...| .|.||..|....:.|  ...|.:|.|..:..
Human   387 IAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHE 451

  Fly   185 KFTSKKMNMDAALLKLNQSLTGT--------NIGTISMGNYRPKAGSRVRIAGWGVTKEGSTTAS 241
            .|:......|.|||:|.:...|:        ....:..|..||...:..::||||...||:...:
Human   452 AFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYA 516

  Fly   242 KTLQTAQIRVVRQQKC-RKDYRGQATITKYMLCA--RAAGKDSCSGDSGGPVT-------RNNTL 296
            ..||.||:..:..::| ..|..| ::|...||||  ...|.|:|.||||||:.       |..||
Human   517 SFLQEAQVPFLSLERCSAPDVHG-SSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTL 580

  Fly   297 LGIVSFGYGCARAGYPGVYTAVVAIRQW 324
            .||:|:|.||.....|||||.|.....|
Human   581 QGIISWGSGCGDRNKPGVYTDVAYYLAW 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32269	NP_001261363.1	Tryp_SPc	108..324	CDD:214473	83/236 (35%)
CG32269	NP_001261363.1	Tryp_SPc	121..324	CDD:238113	79/223 (35%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		Kringle	217..295	CDD:278480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359		8/34 (24%)
		Tryp_SPc	372..609	CDD:214473	84/238 (35%)
		Tryp_SPc	373..612	CDD:238113	83/237 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910