DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11714 and BTBD2

DIOPT Version :9

Sequence 1:	NP_001027123.1	Gene:	CG11714 / 3772566	FlyBaseID:	FBgn0036170	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_060267.2	Gene:	BTBD2 / 55643	HGNCID:	15504	Length:	525	Species:	Homo sapiens

Alignment Length:	272	Identity:	61/272 - (22%)
Similarity:	98/272 - (36%)	Gaps:	74/272 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYECDKLQKYDFD 105
            ||..|.|:.:.:..|.|||.|..|. :.:||..:.|.||:|..|.....::|.   |::| ...:
Human   129 SQRIPAHRFVLAVGSAVFDAMFNGG-MATTSTEIELPDVEPAAFLALLKFLYS---DEVQ-IGPE 188

  Fly   106 TLIRLCEFANKYLVQSLEEDCVKDL---LIRKNTFDMGELLRLFQ-------CAHRMNRKSLINQ 160
            |::.....|.||.|.:||..||:.|   |...|.|.:....|||.       |...::
Human   189 TVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENID------- 246

  Fly   161 IAWELKCTFKSTLDHSGVYEFNCEVFKHYIEVIASKISEADRFRLLEMYLKYNGIEELESAGQVD 225
                     |:|.|                .:.|...::.|             ::.|.:..:.|
Human   247 ---------KNTAD----------------AITAEGFTDID-------------LDTLVAVLERD 273

  Fly   226 SQDATEANT-TTITTTNEVENQESELPSTSCVPLKTECSFAVPNKKASFVSDLLALIDFGKLSPK 289
            :....|... ..:...:|.|.|..:|..|             |..:...:...|.||.|..::.:
Human   274 TLGIREVRLFNAVVRWSEAECQRQQLQVT-------------PENRRKVLGKALGLIRFPLMTIE 325

  Fly   290 EFYDGPGKSNFL 301
            ||..||.:|..|
Human   326 EFAAGPAQSGIL 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11714	NP_001027123.1	BTB	27..131	CDD:279045	30/92 (33%)
CG11714	NP_001027123.1	BTB	29..133	CDD:197585	31/94 (33%)
BTBD2	NP_060267.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..86
		BTB	110..214	CDD:279045	29/89 (33%)
		BTB	118..217	CDD:197585	30/92 (33%)
		BACK	229..328	CDD:197943	23/156 (15%)
		PHR	376..523	CDD:285277
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810