DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skeletor and H06A10.1

DIOPT Version :9

Sequence 1:	NP_001247027.1	Gene:	Skeletor / 3772559	FlyBaseID:	FBgn0262717	Length:	1503	Species:	Drosophila melanogaster
Sequence 2:	NP_510255.1	Gene:	H06A10.1 / 186696	WormBaseID:	WBGene00010368	Length:	291	Species:	Caenorhabditis elegans

Alignment Length:	324	Identity:	78/324 - (24%)
Similarity:	131/324 - (40%)	Gaps:	80/324 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MKDKPWLLLF-----GLLAALSCLASFGDAAYPYYGTKIGALTRLHHGVSGDVYAVDSRTIFIKK 63
            |::..:.|:|     |::.|:.           |.|..:|..:  ...|.|:|:.|:|..:.|..
Worm     1 MRNSEFFLIFIISYSGVIRAIE-----------YNGVSLGEFS--ESDVEGEVFLVNSTHLQIVN 52

  Fly    64 F--NYDGEAPAAYFYVGNTARPSNEGAARLRDERGG-----TASLTRRYRNKDVTLSLPEGKTLR 121
            |  ......|..:.::.:..:.|.....|....:.|     ..||:......|..|.:.  .|..
Worm    53 FRTTKTNLPPIPFAFISSNNQKSTPKIYRHFSSQNGEWLSKLVSLSHEQHQIDTRLIVK--MTGS 115

  Fly   122 DIKWFSVWCDEFAV--NFGDVSIPPNLDFPRPQKISA------------LRGVHGVSSDNIVIVD 172
            ..:|     .:|||  :.|:.....|::    ||.||            |.|.:|:.||.|.::|
Worm   116 AAQW-----KQFAVVDSNGNTLASVNMN----QKPSAPFCCFESEADMGLFGEYGIISDPIEVID 171

  Fly   173 AQTLLVPNFSYD-GEAPDAKFWVGRGQRPTSDGLRIPDENGKENPLRRYER-------------K 223
            ::||.:|.|||. .:.||..|:.|.|.       .|..::||:..:.|.::             :
Worm   172 SRTLKIPKFSYKASQTPDGYFFAGAGS-------EIDQKSGKKAAILRSDQTLNYCPMLKDITDQ 229

  Fly   224 TIVLTLPEDLTIFDIGHFGVWCEAFTVDFGHVRLPEGL-----NVPPSLKMLGISPQSKL--NC 280
            .|::.|.:..||:||....|:|..::.||||  |..||     .|||.:..:.||....:  ||
Worm   230 DIIIRLDQSQTIYDIEWISVFCYKYSHDFGH--LDMGLVENEEQVPPYIPDISISEPHVISQNC 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skeletor	NP_001247027.1	DM13	42..149	CDD:128929	22/115 (19%)
		DM13	158..264	CDD:128929	36/124 (29%)
		DoH	286..447	CDD:214768
H06A10.1	NP_510255.1	DM13	157..270	CDD:128929	36/121 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	0.167	Domainoid score	I6519
eggNOG	1	0.900	-	-		E1_KOG4731
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320761at33208
OrthoFinder	1	1.000	-	-		FOG0005930
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920