DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skeletor and W01C8.5

DIOPT Version :9

Sequence 1:	NP_001247027.1	Gene:	Skeletor / 3772559	FlyBaseID:	FBgn0262717	Length:	1503	Species:	Drosophila melanogaster
Sequence 2:	NP_508959.1	Gene:	W01C8.5 / 180836	WormBaseID:	WBGene00020921	Length:	511	Species:	Caenorhabditis elegans

Alignment Length:	730	Identity:	141/730 - (19%)
Similarity:	228/730 - (31%)	Gaps:	306/730 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LSCLASFGDAAYPY--------YGTKIGALTRLHHGVSGDVYAVDSRTIFIKKFNYDGEAPAAYF 75
            ||..||   :.|.|        ||..:|.|:.....:||.|:.|::.|:.|....:.......||
Worm    11 LSLAAS---STYCYDINTYNADYGVYVGDLSSPETDISGQVFIVNATTLQIFNLTFSPSQQDLYF 72

  Fly    76 YVGNTARPSNEGAARLRDERGGTASLTRRYRNKDVTLSLPEGKTLRDIKWFSVWCDEFAVNFGDV 140
            ::.....|:.||......|.|.|...:....|..|.:.:||...:.:.|.||::..:...:...|
Worm    73 WLDTKDVPTREGIKAHTFEYGITPLGSFPEDNDRVVVHVPEKHRIDEFKSFSIYSFKTDKSMASV 137

  Fly   141 SIPPNLDFPRPQKISA-LRGV-HGVSSDNIVIVDAQTLLVPNFSYDG-EAPDAKFWVGRGQRPT- 201
            ..|.|:..|:..|:|. ..|. :.:.|..:.::|.:|:.|..|:::| :||...|:.|||...:
Worm   138 VFPENVKIPKSVKLSTEFSGKRYQLRSGPLYVIDRRTIKVYGFTFEGNKAPKTYFYAGRGASVSY 202

  Fly   202 SDGLRIPDENGKENPLRRYER-----KTIVLTLPEDLTIFDIGHFGVWCEAFTVDFGHVRLPEG- 260
            |.|:::......|..:.....     |.|:|.|||:..||.|....|:|..:.|:||.|.:|..
Worm   203 SSGVKVAIRGKDEKEISEISENYRGGKDIILELPENYDIFHIDWISVYCYKYRVNFGSVLVPTDD 267

  Fly   261 --LNVPPSLKMLGISPQSKLNCEVLYDDLAFEVRWAVAGESIVVQLVAKLEPNHYMSFGISPNKN 323
              :|:||.:      |..|.|.:               |:.              |:.|:
Worm   268 TLVNLPPYV------PSIKKNTD---------------GKP--------------MARGV----- 292

  Fly   324 ISQMIGADAVVAWVDPQTGNGFATDYFLEGKAQCSGGRGACPDTKISEKTNSIRLLNAAMVNGYS 388
                                       |:|.|               |:||
Worm   293 ---------------------------LKGSA---------------ERTN-------------- 301

  Fly   389 IVTYQRSLAATDRLDLPISITGAESVVWAIGPLNDYQEVSFHTFYNKHLHQIEFGRQPKWNCPLP 453
             .|:|                           |.|.:.:       |:|:
Worm   302 -FTFQ---------------------------LGDVEHI-------KNLN--------------- 316

  Fly   454 EGARGNSNSSEQEDSAPAAQSSTGGAGYPPAGRPNVEPDEEFYENRAEALHRQPPQRRQETAIIT 518
                ||..|
Worm   317 ----GNLRS-------------------------------------------------------- 321

  Fly   519 QRRPVPTPKPVNSNGAWDIPAIQCHEPEDGVFYAQMGPTGGKHGYPAITGHVGWGISWYINGLLI 583
                   ||.|                                              |::|.::.
Worm   322 -------PKYV----------------------------------------------WHVNSVMS 333

  Fly   584 PEIHVVRGKTYTFVVEGGNNPDIPAKYHPFYISDDPVGGYEHKREEEKKAVRIYA-GVHRSRSGQ 647
            |:::::|..||.|.||||....||..|:|.||.||..||:....:.|.:.|.|:: |:..|.:|.
Worm   334 PDLYLMRNVTYNFNVEGGREKMIPELYNPLYIGDDENGGFSELSQNEAERVTIHSPGLIESNTGP 398

  Fly   648 VTPTGVGRLCNW--TPDVEGPPADDYQSFGAYQRTLTLKCDAGEPGV--ITWKPDRNTPDTVYYH 708
                    ||.|  ..|......|.|           |:||.....|  ..:.|:..||..:||:
Worm   399 --------LCIWMHNKDKAANEPDTY-----------LECDGWPEDVHSFAFTPNETTPSVLYYN 444

  Fly   709 CFTHRYLGWKIHVHD 723
            ...:..:|.:|.:.|
Worm   445 SGNNFNMGGRIFIVD 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skeletor	NP_001247027.1	DM13	42..149	CDD:128929	24/106 (23%)
		DM13	158..264	CDD:128929	33/116 (28%)
		DoH	286..447	CDD:214768	15/160 (9%)
W01C8.5	NP_508959.1	DM13	38..146	CDD:128929	24/107 (22%)
W01C8.5	NP_508959.1	DM13	160..264	CDD:383103	30/103 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	0.167	Domainoid score	I6519
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005930
OrthoInspector	1	1.000	-	-		otm14242
orthoMCL	1	0.900	-	-		OOG6_105978
Panther	1	1.100	-	-	O	PTHR24036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16909
SonicParanoid	1	1.000	-	-		X5705
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.940