DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Menl-1 and MAE1

DIOPT Version :9

Sequence 1:	NP_001027428.1	Gene:	Menl-1 / 3772542	FlyBaseID:	FBgn0029154	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_012896.1	Gene:	MAE1 / 853839	SGDID:	S000001512	Length:	669	Species:	Saccharomyces cerevisiae

Alignment Length:	589	Identity:	184/589 - (31%)
Similarity:	303/589 - (51%)	Gaps:	40/589 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IRVPIE---VVFSDKCNKALAFTLEERQRLCIHGLMPACVRTYDEQMLAIESNFHSFESNVGRYR 104
            |..|:|   ::.|...||..|||.|||:...:..|:|..|.|.|||:..........::.:.:..
Yeast    94 IECPLESFQLLNSPLFNKGSAFTQEEREAFNLEALLPPQVNTLDEQLERSYKQLCYLKTPLAKND 158

  Fly   105 YLRALRQGYERLYFQFVSKNVHAVLPIIYTPTVGLACTVYGMLYRGMTGIHITKHDRGHMKQILS 169
            ::.:||...:.|||..:.:::..::|||||||.|.|...|...:|...|:.:...:...::..|:
Yeast   159 FMTSLRVQNKVLYFALIRRHIKELVPIIYTPTEGDAIAAYSHRFRKPEGVFLDITEPDSIECRLA 223

  Fly   170 NWPMRRSVKAICVTDGQRILGLGDLGANGMGIAVGKMELYTALAGIPPSMLLPICLDVGTNNKSL 234
            .:...:.|..|.|:|.:.|||:||.|..|:.||:.|:.|.|...||.|..:||:|||||||||.|
Yeast   224 TYGGDKDVDYIVVSDSEGILGIGDQGIGGVRIAISKLALMTLCGGIHPGRVLPVCLDVGTNNKKL 288

  Fly   235 HEDPLYIGLRDERLKGDEYVCFVDEFMEAVVSTFGDQTLIHFEDFATPNAFMFLNRYQHCYCHFN 299
            ..|.||:|.:..|::|.:|..|:::|::||...: ...::|||||...||...|.:|::....||
Yeast   289 ARDELYMGNKFSRIRGKQYDDFLEKFIKAVKKVY-PSAVLHFEDFGVKNARRLLEKYRYELPSFN 352

  Fly   300 DDIQGTAAVGLGGLLGIQRITKKPLEEHVIVFAGAGSAAMGIAYLLKMELMSRGLSEADAAKNIY 364
            ||||||.||.:..|:...:.|.:.|::..::..|||||.:|||..:...:::.|:.:.:|.|.|:
Yeast   353 DDIQGTGAVVMASLIAALKHTNRDLKDTRVLIYGAGSAGLGIADQIVNHMVTHGVDKEEARKKIF 417

  Fly   365 FYDQDG-VLTTARKSIPDILCVFAKNMKE-----TKSLETLVEQVKPSIIMGATSAPGLFTEKII 423
            ..|:.| :|.:...:......|:||:..|     |:||..:||.|||:.::|.::..|.||:.::
Yeast   418 LMDRRGLILQSYEANSTPAQHVYAKSDAEWAGINTRSLHDVVENVKPTCLVGCSTQAGAFTQDVV 482

  Fly   424 RTMAASHERPGIFAFSNPTIKSECTAEQAYKFSDGKAIYSAGSPFPPVEFNGKRLTPGQANNCFA 488
            ..|...:.||.||..||||...|.......|:::..|:.:.|||||||:  |.|::  :.|||::
Yeast   483 EEMHKHNPRPIIFPLSNPTRLHEAVPADLMKWTNNNALVATGSPFPPVD--GYRIS--ENNNCYS 543

  Fly   489 FPALVLATMTVLATRMPDEIFLLAAHELAEF-PTNEEMQSGRIYPLVKQANEVAYKIGVKVAKYL 552
            ||.:.|..:...||.:.|::...|..:|||. |..|......:.|.:......:.::...|....
Yeast   544 FPGIGLGAVLSRATTITDKMISAAVDQLAELSPLREGDSRPGLLPGLDTITNTSARLATAVILQA 608

  Fly   553 IENGYAKRNLE-------------PEDVEEYIEKNSYKLTYGSSLAETW--AY-PKMKPHPSTAG 601
            :|.|.|:...|             |.|.:|.::...         |:.|  .| |.:|.....:.
Yeast   609 LEEGTARIEQEQVPGGAPGETVKVPRDFDECLQWVK---------AQMWEPVYRPMIKVQHDPSV 664

  Fly   602 HENK 605
            |.|:
Yeast   665 HTNQ 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-1	NP_001027428.1	PLN03129	35..582	CDD:215594	177/561 (32%)
		malic	114..292	CDD:278802	66/177 (37%)
		NAD_bind_1_malic_enz	302..576	CDD:133454	85/293 (29%)
MAE1	NP_012896.1	PRK13529	91..658	CDD:237414	181/577 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346252
Domainoid	1	1.000	155	1.000	Domainoid score	I893
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	332	1.000	Inparanoid score	I422
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		otm46745
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
TreeFam	1	0.960	-	-
	11	10.660