DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Menl-1 and NADP-ME4

DIOPT Version :9

Sequence 1:	NP_001027428.1	Gene:	Menl-1 / 3772542	FlyBaseID:	FBgn0029154	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_178093.1	Gene:	NADP-ME4 / 844314	AraportID:	AT1G79750	Length:	646	Species:	Arabidopsis thaliana

Alignment Length:	529	Identity:	215/529 - (40%)
Similarity:	320/529 - (60%)	Gaps:	3/529 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 NKALAFTLEERQRLCIHGLMPACVRTYDEQMLAIESNFHSFESNVGRYRYLRALRQGYERLYFQF 120
            ||.|||:..||....:.||:|..|.:.|.|:..|......::..:.:|..:..|::..|||:::.
plant   117 NKGLAFSHRERDAHYLRGLLPPTVISQDLQVKKIMHTLRQYQVPLQKYMAMMDLQETNERLFYKL 181

  Fly   121 VSKNVHAVLPIIYTPTVGLACTVYGMLYRGMTGIHITKHDRGHMKQILSNWPMRRSVKAICVTDG 185
            :..:|..:||:|||||||.||..||.::....|:.|:..::|.:.::|.||| .::::.|.||||
plant   182 LIDHVEELLPVIYTPTVGEACQKYGSIFLRPQGLFISLKEKGKIHEVLRNWP-EKNIQVIVVTDG 245

  Fly   186 QRILGLGDLGANGMGIAVGKMELYTALAGIPPSMLLPICLDVGTNNKSLHEDPLYIGLRDERLKG 250
            :|||||||||..||||.|||:.|||||.|:.||..||:.:||||||:.|..|..|||||..|..|
plant   246 ERILGLGDLGCQGMGIPVGKLSLYTALGGVRPSACLPVTIDVGTNNEKLLNDEFYIGLRQRRATG 310

  Fly   251 DEYVCFVDEFMEAVVSTFGDQTLIHFEDFATPNAFMFLNRYQHCYCHFNDDIQGTAAVGLGGLLG 315
            :||...:.|||.||...:|::.:|.|||||..|||..|.:|...:..|||||||||:|.|.||:.
plant   311 EEYSELMHEFMTAVKQNYGEKVVIQFEDFANHNAFDLLAKYGTTHLVFNDDIQGTASVVLAGLIA 375

  Fly   316 IQRITKKPLEEHVIVFAGAGSAAMGIAYLLKMELMSRG-LSEADAAKNIYFYDQDGVLTTARK-S 378
            ..|.....|.:|..:|.|||.|..|||.|:.:|:..:. :...:|.|||:..|..|::.::|| |
plant   376 ALRFVGGSLSDHRFLFLGAGEAGTGIAELIALEISKKSHIPLEEARKNIWLVDSKGLIVSSRKES 440

  Fly   379 IPDILCVFAKNMKETKSLETLVEQVKPSIIMGATSAPGLFTEKIIRTMAASHERPGIFAFSNPTI 443
            |......:|.:.:..:.|...|:.:||::::|.:.....||:.::.|||..:|:|.|.:.||||.
plant   441 IQHFKKPWAHDHEPIRELVDAVKAIKPTVLIGTSGVGQTFTQDVVETMAKLNEKPIILSLSNPTS 505

  Fly   444 KSECTAEQAYKFSDGKAIYSAGSPFPPVEFNGKRLTPGQANNCFAFPALVLATMTVLATRMPDEI 508
            :||||||:||.:|.|:||:::||||.|||:.||...||||||.:.||...|..:.....|:.|::
plant   506 QSECTAEEAYTWSQGRAIFASGSPFAPVEYEGKTFVPGQANNAYIFPGFGLGLIMSGTIRVHDDM 570

  Fly   509 FLLAAHELAEFPTNEEMQSGRIYPLVKQANEVAYKIGVKVAKYLIENGYAKRNLEPEDVEEYIEK 573
            .|.|:..|||....|..:.|.|||..:...:::.:|..|||....|.|.|.|..:|:::|:..|.
plant   571 LLAASEALAEELMEEHYEKGMIYPPFRNIRKISARIAAKVAAKAYELGLATRLPQPKELEQCAES 635

  Fly   574 NSYKLTYGS 582
            :.|..:|.|
plant   636 SMYSPSYRS 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-1	NP_001027428.1	PLN03129	35..582	CDD:215594	214/527 (41%)
		malic	114..292	CDD:278802	88/177 (50%)
		NAD_bind_1_malic_enz	302..576	CDD:133454	103/275 (37%)
NADP-ME4	NP_178093.1	PLN03129	67..646	CDD:215594	215/529 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.780