DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Menl-1 and me2

DIOPT Version :9

Sequence 1:	NP_001027428.1	Gene:	Menl-1 / 3772542	FlyBaseID:	FBgn0029154	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_001015690.1	Gene:	me2 / 548395	XenbaseID:	XB-GENE-943055	Length:	583	Species:	Xenopus tropicalis

Alignment Length:	555	Identity:	237/555 - (42%)
Similarity:	346/555 - (62%)	Gaps:	9/555 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VVFSDKCNKALAFTLEERQRLCIHGLMPACVRTYDEQMLAIESNFHSFESNVGRYRYLRALRQGY 113
            ::.:.:.||.:||||:|||.|.:.||:|..|.:.|.|......|....|..:.:|.|:..:::..
Frog    28 LLLNPRTNKGMAFTLQERQILGLQGLLPPKVESQDIQAARFHRNLSKMEDPLQKYIYIMGIQERN 92

  Fly   114 ERLYFQFVSKNVHAVLPIIYTPTVGLACTVYGMLYRGMTGIHITKHDRGHMKQILSNWPMRRSVK 178
            |:|:::.:..::..::||:|||||||||:.||..:|...|::|:..||||::.||.:|| ...||
Frog    93 EKLFYRILLDDIEHLMPIVYTPTVGLACSQYGHTFRRPKGLYISILDRGHIRSILDHWP-ETDVK 156

  Fly   179 AICVTDGQRILGLGDLGANGMGIAVGKMELYTALAGIPPSMLLPICLDVGTNNKSLHEDPLYIGL 243
            |:.||||:||||||:||..||||.|||:.||||.|||.|...||:.:||||:|.:|.:||.|:||
Frog   157 AVVVTDGERILGLGNLGVYGMGIPVGKLCLYTACAGIRPQKCLPVVIDVGTDNPTLLKDPFYMGL 221

  Fly   244 RDERLKGDEYVCFVDEFMEAVVSTFGDQTLIHFEDFATPNAFMFLNRYQHCYCHFNDDIQGTAAV 308
            ..:|.:...|...:||||:||...:|..|||.||||...|||.||.:|:..||.|||||||||:|
Frog   222 YQKRDRTQLYDDLIDEFMDAVTDRYGQNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTASV 286

  Fly   309 GLGGLLGIQRITKKPLEEHVIVFAGAGSAAMGIAYLLKMELMSRGLSEADAAKNIYFYDQDGVLT 373
            .|.|:|..|:...||:.||.|:|.|||.||:|||.|:.|.:|..|:|...|.:.|:.:|:.|:|.
Frog   287 ALAGMLAAQKAIGKPITEHKILFLGAGEAALGIANLIVMSMMENGISAEAARERIWMFDKFGLLI 351

  Fly   374 TAR-KSIPDILCVFAKNMKETKSLETLVEQVK---PSIIMGATSAPGLFTEKIIRTMAASHERPG 434
            ..| :.|......||.:..| :::.:.::.||   |:.|:|...|..||||.:|:.||:.:|||.
Frog   352 QGRGEGIDSNQESFAHSAPE-QAVGSFLDAVKVLQPTAIIGVAGAGKLFTEDVIKEMASINERPI 415

  Fly   435 IFAFSNPTIKSECTAEQAYKFSDGKAIYSAGSPFPPVEF-NGKRLTPGQANNCFAFPALVLATMT 498
            |||.||||:|:|||||:||.:::|:.::::||||..|.. :|:...|||.||.:.||.:.||.:.
Frog   416 IFALSNPTVKAECTAEEAYTWTEGQCLFASGSPFDTVTLSDGRSFKPGQGNNAYIFPGVALAVIL 480

  Fly   499 VLATRMPDEIFLLAAHELAEFPTNEEMQSGRIYPLVKQANEVAYKIGVKVAKYLIENGYAKRNLE 563
            .....:.|.:||.||..|||..|.||:..||:||.:....||:..|.|||.:::..||.|.:..|
Frog   481 SGVRHISDRVFLEAAKALAEQLTAEELGQGRLYPPLSNIREVSICIAVKVMEFVYRNGMAFQYPE 545

  Fly   564 PEDVEEYIEKNSYKLTYGSSLAETWAYPK--MKPH 596
            |.....||....:...|.|...:.:.:|:  .|||
Frog   546 PVGKNAYIRSKVWSTDYDSFPPDVYDWPEYASKPH 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-1	NP_001027428.1	PLN03129	35..582	CDD:215594	232/537 (43%)
		malic	114..292	CDD:278802	90/177 (51%)
		NAD_bind_1_malic_enz	302..576	CDD:133454	114/278 (41%)
me2	NP_001015690.1	PLN03129	25..565	CDD:215594	232/538 (43%)
		malic	89..270	CDD:278802	90/181 (50%)
		NAD_bind_1_malic_enz	280..560	CDD:133454	114/280 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11846
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.000