Protein Alignment Menl-1 and me3

DIOPT Version :9

• Sequence 1: NP_001027428.1
• Gene: Menl-1 / 3772542
• FlyBaseID: FBgn0029154
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_001082825.1
• Gene: me3 / 492719
• ZFINID: ZDB-GENE-041111-294
• Length: 603
• Species: Danio rerio
• Alignment Length: 538
• Identity: 244/538 - (45%)
• Similarity: 351/538 - (65%)
• Gaps: 2/538 - (0%)

  Fly    56 NKALAFTLEERQRLCIHGLMPACVRTYDEQMLAIESNFHSFESNVGRYRYLRALRQGYERLYFQF 120
            ||.:|||||||.:|.||||:|.|..:.|.|:|.:..::.:..:.:.:|..|..|:...|:|:::.
Zfish    59 NKGMAFTLEERLQLGIHGLLPPCFLSQDVQVLRVMKSYETRSNPLDKYILLMTLQDRNEKLFYRV 123

  Fly   121 VSKNVHAVLPIIYTPTVGLACTVYGMLYRGMTGIHITKHDRGHMKQILSNWPMRRSVKAICVTDG 185
            ::.::...:||:|||||||||..||:.:|...|:.||.||:||:..:|::|| ...:|||.||||
Zfish   124 LTSDIEEFMPIVYTPTVGLACQQYGLAFRRPRGLFITIHDKGHIATMLNSWP-EEDIKAIVVTDG 187

  Fly   186 QRILGLGDLGANGMGIAVGKMELYTALAGIPPSMLLPICLDVGTNNKSLHEDPLYIGLRDERLKG 250
            :|||||||||..||||.|||:.||||..|:||...||:.|||||:|::|.:|||||||:.:|::|
Zfish   188 ERILGLGDLGGYGMGIPVGKLALYTACGGVPPQQCLPVLLDVGTDNQTLLDDPLYIGLKHKRVRG 252

  Fly   251 DEYVCFVDEFMEAVVSTFGDQTLIHFEDFATPNAFMFLNRYQHCYCHFNDDIQGTAAVGLGGLLG 315
            .||...:||||:||...:|...||.|||||..|||..||:|::.||.|||||||||:|.:.|:|.
Zfish   253 KEYDDLIDEFMQAVTDKYGMNCLIQFEDFANSNAFRILNKYRNRYCTFNDDIQGTASVAVAGILA 317

  Fly   316 IQRITKKPLEEHVIVFAGAGSAAMGIAYLLKMELMSRGLSEADAAKNIYFYDQDGVLTTARKSIP 380
            ..:|||..|.:|..||.|||.||:|||:||.|.:...|:..|:||:.|:..|..|::...|..:.
Zfish   318 ALKITKNKLSDHKFVFQGAGEAALGIAHLLIMAMAKEGIPHAEAAQRIWMVDSKGLIVKGRSHLN 382

  Fly   381 DILCVFAKNMKETKSLETLVEQVKPSIIMGATSAPGLFTEKIIRTMAASHERPGIFAFSNPTIKS 445
            .....||.:....|:||.:||.:||:.|:|..:..|.||||||:.|||::|||.|||.||||.|:
Zfish   383 HEKEEFAHDHPHIKTLEEVVETIKPTAIIGVAAIGGAFTEKIIKNMAANNERPIIFALSNPTSKA 447

  Fly   446 ECTAEQAYKFSDGKAIYSAGSPFPPVEF-NGKRLTPGQANNCFAFPALVLATMTVLATRMPDEIF 509
            ||||||.|..::|:.|:::||||..|.. :|:...|||.||.:.||.:.|..:......:.|:||
Zfish   448 ECTAEQCYTLTEGRGIFASGSPFKKVTLADGRSFYPGQGNNAYVFPGVALGVIACGVRHISDDIF 512

  Fly   510 LLAAHELAEFPTNEEMQSGRIYPLVKQANEVAYKIGVKVAKYLIENGYAKRNLEPEDVEEYIEKN 574
            |..|..::|..|.|.:..||:||.:|...||::||.||:..:..:.|.|....||:|.|.:|..:
Zfish   513 LTTAEAISEMVTEEHLAEGRLYPPLKTIREVSFKIAVKIVDHAYKQGIASWYPEPKDKEAFILSH 577

  Fly   575 SYKLTYGSSLAETWAYPK 592
            .|...|.|...:::::||
Zfish   578 VYNSDYDSFTLDSYSWPK 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Menl-1	NP_001027428.1	PLN03129	35..582	CDD:215594	241/526 (46%)
		malic	114..292	CDD:278802	95/177 (54%)
		NAD_bind_1_malic_enz	302..576	CDD:133454	115/274 (42%)
me3	NP_001082825.1	PLN03129	47..587	CDD:215594	242/528 (46%)
		malic	113..294	CDD:278802	95/181 (52%)
		NAD_bind_1_malic_enz	304..580	CDD:133454	115/275 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.710