Protein Alignment Menl-1 and ME2

DIOPT Version :10

• Sequence 1: NP_001027428.1
• Gene: Menl-1 / 3772542
• FlyBaseID: FBgn0029154
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_002387.1
• Gene: ME2 / 4200
• HGNCID: 6984
• Length: 584
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 246/566 - (43%)
• Similarity: 353/566 - (62%)
• Gaps: 31/566 - (5%)

  Fly    49 VVFSDKCNKALAFTLEERQRLCIHGLMPACVRTYDEQMLAIESNFHSFESNVGRYRYLRALRQGY 113
            ::.:.:.||.:||||:|||.|.:.||:|..:.|.|.|.|....|.....|.:.:|.|:..:::..
Human    28 LMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERN 92

  Fly   114 ERLYFQFVSKNVHAVLPIIYTPTVGLACTVYGMLYRGMTGIHITKHDRGHMKQILSNWPMRRSVK 178
            |:|:::.:..::.:::||:|||||||||:.||.::|...|:.|:..||||::.|:.||| ...||
Human    93 EKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWP-ENHVK 156

  Fly   179 AICVTDGQRILGLGDLGANGMGIAVGKMELYTALAGIPPSMLLPICLDVGTNNKSLHEDPLYIGL 243
            |:.||||:|||||||||..||||.|||:.||||.|||.|...||:|:||||:|.:|.:||.|:||
Human   157 AVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGL 221

  Fly   244 RDERLKGDEYVCFVDEFMEAVVSTFGDQTLIHFEDFATPNAFMFLNRYQHCYCHFNDDIQGTAAV 308
            ..:|.:..:|...:||||:|:...:|..|||.||||...|||.||.:|:..||.|||||||||||
Human   222 YQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAV 286

  Fly   309 GLGGLLGIQRITKKPLEEHVIVFAGAGSAAMGIAYLLKMELMSRGLSEADAAKNIYFYDQDGVLT 373
            .|.|||..|::..||:.||.|:|.|||.||:|||.|:.|.::..||||.:|.|.|:.:|:.|:|.
Human   287 ALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLV 351

  Fly   374 TARK----------------SIPDILCVFAKNMKETKSLETLVEQVKPSIIMGATSAPGLFTEKI 422
            ..||                ||||             :.|..|..:|||.|:|...|..|||..:
Human   352 KGRKAKIDSYQEPFTHSAPESIPD-------------TFEDAVNILKPSTIIGVAGAGRLFTPDV 403

  Fly   423 IRTMAASHERPGIFAFSNPTIKSECTAEQAYKFSDGKAIYSAGSPFPPVEF-NGKRLTPGQANNC 486
            ||.||:.:|||.|||.||||.::|||||:||..::|:.::::||||.||:. :|:..||||.||.
Human   404 IRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNV 468

  Fly   487 FAFPALVLATMTVLATRMPDEIFLLAAHELAEFPTNEEMQSGRIYPLVKQANEVAYKIGVKVAKY 551
            :.||.:.||.:......:.|.:||.||..|....|:||:..||:||.:....||:..|.:||.:|
Human   469 YIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEY 533

  Fly   552 LIENGYAKRNLEPEDVEEYIEKNSYKLTYGSSLAETWAYPKMKPHP 597
            |..|..|.|..||||..:|:::.:::..|.|.|.:.:.:|:....|
Human   534 LYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSP 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Menl-1	NP_001027428.1	PLN03129	35..582	CDD:215594	242/549 (44%)
ME2	NP_002387.1	PLN03129	28..566	CDD:215594	243/551 (44%)