Protein Alignment Menl-1 and Menl-2

DIOPT Version :9

• Sequence 1: NP_001027428.1
• Gene: Menl-1 / 3772542
• FlyBaseID: FBgn0029154
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_001027424.2
• Gene: Menl-2 / 3772692
• FlyBaseID: FBgn0029153
• Length: 600
• Species: Drosophila melanogaster
• Alignment Length: 549
• Identity: 269/549 - (48%)
• Similarity: 383/549 - (69%)
• Gaps: 1/549 - (0%)

  Fly    49 VVFSDKCNKALAFTLEERQRLCIHGLMPACVRTYDEQMLAIESNFHSFESNVGRYRYLRALRQGY 113
            ||.:.|.||.||||::|||||.|.||||..||:.|:||.|..:||.:..:::.|:.||.|:...:
  Fly    41 VVMNGKYNKGLAFTIKERQRLGIMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYLSAVHHRH 105

  Fly   114 ERLYFQFVSKNVHAVLPIIYTPTVGLACTVYGMLYRGMTGIHITKHDRGHMKQILSNWPMRRSVK 178
            .|||::|:.:|:...|||:||||||.....||:.::....:.|:.||:||::.::.|| :...||
  Fly   106 RRLYYRFIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNW-VDEGVK 169

  Fly   179 AICVTDGQRILGLGDLGANGMGIAVGKMELYTALAGIPPSMLLPICLDVGTNNKSLHEDPLYIGL 243
            |||||||.|:|||||:|||.|||::|||.|||||..||||.|:|:||||||:|::|.:||||:|.
  Fly   170 AICVTDGGRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQDPLYVGA 234

  Fly   244 RDERLKGDEYVCFVDEFMEAVVSTFGDQTLIHFEDFATPNAFMFLNRYQHCYCHFNDDIQGTAAV 308
            |..|:||.||...||||||:.|..||:.|.|||||||||||..||.:||:.||.||||||||.|.
  Fly   235 RIPRVKGPEYDELVDEFMESAVKCFGNNTFIHFEDFATPNALKFLEKYQYKYCCFNDDIQGTGAT 299

  Fly   309 GLGGLLGIQRITKKPLEEHVIVFAGAGSAAMGIAYLLKMELMSRGLSEADAAKNIYFYDQDGVLT 373
            ||...:.::|||.:.||:.|.:|.||||||:|||.:|.|||..||:...:|.||||..|.:|:||
  Fly   300 GLAAFINVERITGRKLEDTVFLFVGAGSAALGIANMLAMELEVRGIPAEEATKNIYLMDVNGILT 364

  Fly   374 TARKSIPDILCVFAKNMKETKSLETLVEQVKPSIIMGATSAPGLFTEKIIRTMAASHERPGIFAF 438
            ....:.|::..:|.|:|:..|.:..:::::|||:::|||...|:|.|::::|||.:||||.:|..
  Fly   365 PESPNPPEMGKIFIKSMEPMKDMMAVLKKLKPSVLVGATGVGGIFNEEVLKTMAKNHERPAVFPL 429

  Fly   439 SNPTIKSECTAEQAYKFSDGKAIYSAGSPFPPVEFNGKRLTPGQANNCFAFPALVLATMTVLATR 503
            ||||..||||||||:..::|:.::.:|||||||..||||..|.|||||..||.:.||.:|..|..
  Fly   430 SNPTANSECTAEQAFTHTEGRVLFGSGSPFPPVVINGKRYRPAQANNCLTFPGIALAAITAKARY 494

  Fly   504 MPDEIFLLAAHELAEFPTNEEMQSGRIYPLVKQANEVAYKIGVKVAKYLIENGYAKRNLEPEDVE 568
            :|:|:|.:.:||||.....|.:..|.::|.:|.|:.||:.:||.:.:|||:|..:....:|:|:.
  Fly   495 LPNEVFSVVSHELARNTPQELLDEGTLFPPIKDAHNVAFNVGVAMTQYLIDNDLSNVYPKPDDIC 559

  Fly   569 EYIEKNSYKLTYGSSLAETWAYPKMKPHP 597
            |:::::.||..|.:||..||.||...|.|
  Fly   560 EFVKRSLYKFDYRNSLPTTWDYPVEPPTP 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Menl-1	NP_001027428.1	PLN03129	35..582	CDD:215594	261/532 (49%)
		malic	114..292	CDD:278802	100/177 (56%)
		NAD_bind_1_malic_enz	302..576	CDD:133454	119/273 (44%)
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	261/532 (49%)
		malic	102..283	CDD:278802	100/181 (55%)
		NADB_Rossmann	293..567	CDD:304358	119/273 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469223
Domainoid	1	1.000	50	1.000	Domainoid score	I11691
eggNOG	1	0.900	-	-		E1_COG0281
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I37
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		otm51392
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	P	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
	10	9.790