DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Menl-1 and mae2

DIOPT Version :9

Sequence 1:	NP_001027428.1	Gene:	Menl-1 / 3772542	FlyBaseID:	FBgn0029154	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_587760.1	Gene:	mae2 / 2539592	PomBaseID:	SPCC794.12c	Length:	565	Species:	Schizosaccharomyces pombe

Alignment Length:	561	Identity:	197/561 - (35%)
Similarity:	303/561 - (54%)	Gaps:	17/561 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PSSSHDTIRVPIE---VVFSDKCNKALAFTLEERQRLCIHGLMPACVRTYDEQMLAIESNFHSF- 96
            |:.:.:.|..|::   ::.|.:.||..|||.||||:..|...:|..|.|..:|:......:.:.
pombe     2 PAGTKEQIECPLKGVTLLNSPRYNKDTAFTPEERQKFEISSRLPPIVETLQQQVDRCYDQYKAIG 66

  Fly    97 ESNVGRYRYLRALRQGYERLYFQFVSKNVHAVLPIIYTPTVGLACTVYGMLYRGMTG--IHITKH 159
            :..:.:..||..|....:.|::..:|:::..::|||||||.|.|...:..:||...|  :.|..:
pombe    67 DEPLQKNLYLSQLSVTNQTLFYALISQHLIEMIPIIYTPTEGDAIKQFSDIYRYPEGCYLDIDHN 131

  Fly   160 DRGHMKQILSNWPMRRSVKAICVTDGQRILGLGDLGANGMGIAVGKMELYTALAGIPPSMLLPIC 224
            |..::||.||.:....||:.|.:||.:.|||:||.|..|:.|:|.|..|.|..||:.|:..|||.
pombe   132 DLSYIKQQLSEFGKSDSVEYIIITDSEGILGIGDQGVGGVLISVAKGHLMTLCAGLDPNRFLPIV 196

  Fly   225 LDVGTNNKSLHEDPLYIGLRDERLKGDEYVCFVDEFMEAVVSTFGDQTLIHFEDFATPNAFMFLN 289
            |||||||::..::..|:|||.:|::|::|..|:|..::|:...| .:..||||||...||...|:
pombe   197 LDVGTNNETHRKNHQYMGLRKDRVRGEQYDSFLDNVIKAIREVF-PEAFIHFEDFGLANAKRILD 260

  Fly   290 RYQHCYCHFNDDIQGTAAVGLGGLLGIQRITKKPLEEHVIVFAGAGSAAMGIAYLLKMELMSRGL 354
            .|:.....||||||||.||.|..::|...:||.||.|..|:..|||:|.:|||..:...:::.||
pombe   261 HYRPDIACFNDDIQGTGAVALAAIIGALHVTKSPLTEQRIMIFGAGTAGVGIANQIVAGMVTDGL 325

  Fly   355 SEADAAKNIYFYDQDGVLTTARKSI-PDILCVFAK---NMKETKS----LETLVEQVKPSIIMGA 411
            |...|..|::..|:.|:|......| .|....|.|   :.||..|    ||:.:..|||:|::|.
pombe   326 SLDKARGNLFMIDRCGLLLERHAKIATDGQKPFLKKDSDFKEVPSGDINLESAIALVKPTILLGC 390

  Fly   412 TSAPGLFTEKIIRTMAASHERPGIFAFSNPTIKSECTAEQAYKFSDGKAIYSAGSPFPPVEFNGK 476
            :..||.||||.||.|:...|||.||..||||...|...:|..|:|||||:.:.|||.||:..|||
pombe   391 SGQPGKFTEKAIREMSKHVERPIIFPISNPTTLMEAKPDQIDKWSDGKALIATGSPLPPLNRNGK 455

  Fly   477 RLTPGQANNCFAFPALVLATMTVLATRMPDEIFLLAAHELAEFPTNEEMQSGRIYPLVKQANEVA 541
            :....|.||...:|||.:|.:......:.|.:...|:..||..|.:.......:.|.:..|.|::
pombe   456 KYVISQCNNALLYPALGVACVLSRCKLLSDGMLKAASDALATVPRSLFAADEALLPDLNNAREIS 520

  Fly   542 YKIGVKVAKYLIENGYAKRNLEPED--VEEYIEKNSYKLTY 580
            ..|...|.|..:..|.:..:|..:|  ::|:|.:..:...|
pombe   521 RHIVFAVLKQAVSEGMSTVDLPKDDAKLKEWIIEREWNPEY 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-1	NP_001027428.1	PLN03129	35..582	CDD:215594	197/561 (35%)
		malic	114..292	CDD:278802	70/179 (39%)
		NAD_bind_1_malic_enz	302..576	CDD:133454	100/283 (35%)
mae2	NP_587760.1	PRK13529	1..565	CDD:237414	197/561 (35%)
		malic	82..263	CDD:278802	70/181 (39%)
		NAD_bind_1_malic_enz	273..559	CDD:133454	100/285 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	147	1.000	Domainoid score	I1122
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I521
OMA	1	1.010	-	-		QHG60768
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm9297
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
TreeFam	1	0.960	-	-
	10	9.730