DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Menl-1 and ME3

DIOPT Version :9

Sequence 1:	NP_001027428.1	Gene:	Menl-1 / 3772542	FlyBaseID:	FBgn0029154	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_001014811.1	Gene:	ME3 / 10873	HGNCID:	6985	Length:	604	Species:	Homo sapiens

Alignment Length:	571	Identity:	252/571 - (44%)
Similarity:	355/571 - (62%)	Gaps:	11/571 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CECSPNLIKIRP--SSSHDTIRVPIEVVFSDKCNKALAFTLEERQRLCIHGLMPACVRTYDEQML 87
            |...|...:..|  ...:|..|.|       ..||.:|||||||.:|.||||:|.|..:.|.|:|
Human    34 CHSKPGPARPVPLKKRGYDVTRNP-------HLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLL 91

  Fly    88 AIESNFHSFESNVGRYRYLRALRQGYERLYFQFVSKNVHAVLPIIYTPTVGLACTVYGMLYRGMT 152
            .|...:...:|::.:|..|..|:...|:|:::.::.:|...:||:|||||||||..||:.:|...
Human    92 RIMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPR 156

  Fly   153 GIHITKHDRGHMKQILSNWPMRRSVKAICVTDGQRILGLGDLGANGMGIAVGKMELYTALAGIPP 217
            |:.||.||:||:..:|::|| ..::||:.||||:|||||||||..||||.|||:.||||..|:.|
Human   157 GLFITIHDKGHLATMLNSWP-EDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNP 220

  Fly   218 SMLLPICLDVGTNNKSLHEDPLYIGLRDERLKGDEYVCFVDEFMEAVVSTFGDQTLIHFEDFATP 282
            ...||:.|||||||:.|..|||||||:.:|:.|..|...:||||:||...||...||.|||||..
Human   221 QQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANA 285

  Fly   283 NAFMFLNRYQHCYCHFNDDIQGTAAVGLGGLLGIQRITKKPLEEHVIVFAGAGSAAMGIAYLLKM 347
            |||..||:|::.||.|||||||||:|.:.|:|...||||..|..||.||.|||.||||||:||.|
Human   286 NAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVM 350

  Fly   348 ELMSRGLSEADAAKNIYFYDQDGVLTTARKSIPDILCVFAKNMKETKSLETLVEQVKPSIIMGAT 412
            .|...|:.:|:|.:.|:..|..|::...|..:.....:||::..|..|||.:|..|||:.|:|..
Human   351 ALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVA 415

  Fly   413 SAPGLFTEKIIRTMAASHERPGIFAFSNPTIKSECTAEQAYKFSDGKAIYSAGSPFPPVEF-NGK 476
            :..|.|||:|:|.||:.||||.|||.||||.|:|||||:.|:.::|:.|:::||||..|.. :||
Human   416 AIAGAFTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK 480

  Fly   477 RLTPGQANNCFAFPALVLATMTVLATRMPDEIFLLAAHELAEFPTNEEMQSGRIYPLVKQANEVA 541
            ...|||.||.:.||.:.|..:......:|||||||.|.::|:..:.:.:..||:||.:....:|:
Human   481 TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVS 545

  Fly   542 YKIGVKVAKYLIENGYAKRNLEPEDVEEYIEKNSYKLTYGSSLAETWAYPK 592
            .:|.:||..|..::..|....||:|.|.::....|...|.|...:::.:||
Human   546 LRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPK 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-1	NP_001027428.1	PLN03129	35..582	CDD:215594	247/549 (45%)
		malic	114..292	CDD:278802	95/177 (54%)
		NAD_bind_1_malic_enz	302..576	CDD:133454	115/274 (42%)
ME3	NP_001014811.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..50		3/15 (20%)
ME3	NP_001014811.1	PLN03129	38..588	CDD:215594	249/557 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850