DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Menl-1 and me1

DIOPT Version :9

Sequence 1:	NP_001027428.1	Gene:	Menl-1 / 3772542	FlyBaseID:	FBgn0029154	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	XP_002938500.1	Gene:	me1 / 100489590	XenbaseID:	XB-GENE-1013221	Length:	589	Species:	Xenopus tropicalis

Alignment Length:	558	Identity:	244/558 - (43%)
Similarity:	354/558 - (63%)	Gaps:	10/558 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 HDTIRVPIEVVFSDKCNKALAFTLEERQRLCIHGLMPACVRTYDEQMLAIESNFHSFESNVGRYR 104
            |.|.:...::......||.:||:||||.:|.||||:|.|..:.|.|:|.:..|:...:.::.||.
Frog    27 HYTKKRGYDITRDPHLNKGMAFSLEERLQLGIHGLLPPCFLSQDVQVLRVLRNYERQKCDLDRYI 91

  Fly   105 YLRALRQGYERLYFQFVSKNVHAVLPIIYTPTVGLACTVYGMLYRGMTGIHITKHDRGHMKQILS 169
            .|..|:...|:|:::.::.::...:|::|||||||||..||:.:|...|:.||.|||||:..::.
Frog    92 LLMGLQDRNEKLFYKVLTSDIERFMPVVYTPTVGLACQQYGLAFRRPRGLFITIHDRGHISTVMK 156

  Fly   170 NWPMRRSVKAICVTDGQRILGLGDLGANGMGIAVGKMELYTALAGIPPSMLLPICLDVGTNNKSL 234
            :|| ..::||:.||||:|||||||||:.||||.|||:.||||..|:.|...||:.|||||:|:.|
Frog   157 SWP-EDNIKAVVVTDGERILGLGDLGSYGMGIPVGKLALYTACGGVQPQECLPVMLDVGTDNQEL 220

  Fly   235 HEDPLYIGLRDERLKGDEYVCFVDEFMEAVVSTFGDQTLIHFEDFATPNAFMFLNRYQHCYCHFN 299
            ..||||||||..|::|.||...|||||:||...:|...||.|||||..|||..||.|::.||.||
Frog   221 LNDPLYIGLRHRRVRGKEYDELVDEFMKAVTERYGINCLIQFEDFANANAFRLLNMYRNKYCTFN 285

  Fly   300 DDIQGTAAVGLGGLLGIQRITKKPLEEHVIVFAGAGSAAMGIAYLLKMELMSRGLSEADAAKNIY 364
            |||||||||.:.||||..||||..|.:|.::|.|||.||||||.|:.|.:...|.....|.|||:
Frog   286 DDIQGTAAVAVAGLLGALRITKNKLSDHTVLFQGAGEAAMGIADLIVMAMEKEGTPRDAAIKNIW 350

  Fly   365 FYDQDGVLTTARKSIPDILCVFAKNMKETKSLETLVEQVKPSIIMGATSAPGLFTEKIIRTMAAS 429
            ..|..|::...|.|:......||...||.||||.:|:.:||::::|..:..|.|||:||:.||:.
Frog   351 MVDSKGLIVKGRASLNHEKERFAHPHKEMKSLEEVVKDIKPTVLIGVAAIGGAFTEQIIKDMASF 415

  Fly   430 HERPGIFAFSNPTIKSECTAEQAYKFSDGKAIYSAGSPFPPVEF-NGKRLTPGQANNCFAFPALV 493
            :.||.|||.||||.|:||||||.|:.:.|:.|:::||||.||.. :|:.|.|||.||.:.||.:.
Frog   416 NNRPIIFALSNPTSKAECTAEQCYRLTQGRGIFASGSPFDPVTLPDGRTLYPGQGNNAYVFPGVA 480

  Fly   494 LATMTVLATRMPDEIFLLAAHELAEFPTNEEMQSGRIYPLVKQANEVAYKIGVKVAKYLIENGYA 558
            |..:......:.|::||..|..:|:..:::.::.||:||.::...||:.||.||:    :||.|.
Frog   481 LGVVACGVRHISDDVFLTTAEIIAQQVSDKHLEEGRLYPPLQTIQEVSVKIAVKI----VENAYK 541

  Fly   559 KRNL----EPEDVEEYIEKNSYKLTYGSSLAETWAYPK 592
            ..:.    |||:.|.::....|...|...:.:::::|:
Frog   542 DNSASVFPEPENKEAFVRSQMYSTDYDQFMVDSYSWPQ 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-1	NP_001027428.1	PLN03129	35..582	CDD:215594	243/546 (45%)
		malic	114..292	CDD:278802	94/177 (53%)
		NAD_bind_1_malic_enz	302..576	CDD:133454	115/278 (41%)
me1	XP_002938500.1	PLN03129	31..571	CDD:215594	241/544 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020