DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gr59e and Scnn1g

DIOPT Version :9

Sequence 1:	NP_788431.1	Gene:	Gr59e / 37725	FlyBaseID:	FBgn0041233	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_058742.2	Gene:	Scnn1g / 24768	RGDID:	3641	Length:	650	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	102/537 - (18%)
Similarity:	174/537 - (32%)	Gaps:	207/537 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VYPSGRVGVLRWL-HTLWSLFLLMYIWTGSIVKCLEFTVEIPTIEKLLYLMEFPGNMATI----- 77
            |...||:..|.|: .||.::.|:  ||..:::....:||.: :|:.....::||.  .||
  Rat    45 VVSRGRLRRLLWIAFTLTAVALI--IWQCALLVFSFYTVSV-SIKVHFQKLDFPA--VTICNINP 104

  Fly    78 -------------------AILVYYAVLNR----------PLAHGAELQIERIITGL------KG 107
                               |:|..|.|...          ....|...:..::|..|      ||
  Rat   105 YKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTPPRFFKLIPLLVFNENEKG 169

  Fly   108 KAK------------RLVYKRHGQRTLHLMATTLVFHGLCV--LVDVVNYDF--------EFWTT 150
            ||:            ::::|......:| .:..||...||.  ..|...|.|        |::..
  Rat   170 KARDFFTGRKRKISGKIIHKASNVMHVH-ESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKL 233

  Fly   151 WSSNSVYNLPGLMMSLGVLQYAQPVHFLWLVMDQMRMCLKELKLLQRPPQGSTKLDACY-----E 210
            ...|.:..:| |...:. :.|:.....:....|.|....:...|...|..|:     ||     |
  Rat   234 HYMNIMAQVP-LEKKIN-MSYSAKELLVTCFFDGMSCDARNFTLFHHPMYGN-----CYTFNNKE 291

  Fly   211 SAFAVLVDAGGGS------ALMIEEMRYTCNLIEQVHSQFLLR---------------------- 247
            :| .:|..:.|||      .|.|.|..|...|:....::.|:.
  Rat   292 NA-TILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLIHQQNEYPFIEDVGMEIETAMSTS 355

  Fly   248 FGLYL---------------------VLNLLNSLVSICVELYLIF-------------------- 271
            .|::|                     |.|:.|:..|:.:.||..|
  Rat   356 IGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPA 420

  Fly   272 ----NFFETPLWEESVLLVYRLLWLAMHGGRIWFILSVNEQ-----ILEQKC---------NLCQ 318
                |:.:.|.|    :..|..|:.|.          |.|:     :.:|.|         :|.|
  Rat   421 ANYCNYQQHPNW----MYCYYQLYQAF----------VREELGCQSVCKQSCSFKEWTLTTSLAQ 471

  Fly   319 ---------LLNELE-VCSSRLQRTINR--------FLLQL-QRSI-DQPLEACGIVTLDTRSLG 363
                     |||.|. ..|.::.:.:|:        |...| |||| :.|..:   :.:...:.|
  Rat   472 WPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANS---IEMLLSNFG 533

  Fly   364 GFIGVLMAI-VIFLIQI 379
            |.:|:.|:. |:.:|:|
  Rat   534 GQLGLWMSCSVVCVIEI 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gr59e	NP_788431.1	7tm_7	9..381	CDD:285581	102/537 (19%)
Scnn1g	NP_058742.2	ENaC	24..631	CDD:273304	102/537 (19%)
Scnn1g	NP_058742.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900