DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Indy-2 and PHO87

DIOPT Version :9

Sequence 1:	NP_001027201.1	Gene:	Indy-2 / 3772456	FlyBaseID:	FBgn0260466	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_009966.2	Gene:	PHO87 / 850403	SGDID:	S000000633	Length:	923	Species:	Saccharomyces cerevisiae

Alignment Length:	549	Identity:	113/549 - (20%)
Similarity:	209/549 - (38%)	Gaps:	150/549 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GKASIIIPLITLPI-LIYGFQT--DMAEFKCLWLIVTMALLWITETLPIYVTALF-PLVFC---- 78
            ||.::.|..|.:.. ::.|.:|  |..|.:|:.|:...|.||.:|.:|:::|.|. ||:..
Yeast   456 GKRAMKIGFIIIVTGVLLGVKTFNDPVEHRCMALVECCAFLWASEAIPLHITGLLVPLLTVLFRV 520

  Fly    79 ------PLLGLVNASI-VCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLF 136
                  .::|...||. :....::.||::.|.|..:...:...|:...:|..::.:.|..||.:.
Yeast   521 LKDDDGKVMGAAAASTEILGTMWSSTIMILLAGFTLGEALSQYNVAKVLASWLLALAGTKPRNVL 585

  Fly   137 VGLMSVSTFMGLWISNSAGTAMMCPIVKALVNELDTNKIFPVYMTQEEEPVEEGEPPHPSKITVA 201
            :..|||..|:.:||||.|...:...::..|::.||                      :.|....|
Yeast   586 LMAMSVVFFLSMWISNVASPVLTYSLLTPLLDPLD----------------------YTSPFAKA 628

  Fly   202 FYAGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIP---LMVIVNVTLV 263
            ...|:|.::.|||:.:.|.:..|::... |.:.:     .|.:..|...::|   |.::.:..|:
Yeast   629 LVMGVALSADIGGMASPISSPQNIISMQ-YLKPY-----GIGWGQFFAVALPTGILSMLCSWALM 687

  Fly   264 IIAFLI--THMGLFRPNSKTGKIIAEANTNRKLMEDVLRQRHIDLGPMS-----CHEIQMAIAFA 321
            |:.|.|  |.:..|:|       |....|        ::|..|.:..::     |.|.|:..||
Yeast   688 ILTFKIGKTKLEKFKP-------IRTRFT--------IKQYFIIIVTIATILLWCVESQIESAF- 736

  Fly   322 FMIVLLITRKPGFVPGWSDLINRKVVGSASGLSFIVLLIFALPTQYTFFKYCCGKGPFTAQAIDA 386
                                      ||:..::.|.:::|            .|.|..:.:..:
Yeast   737 --------------------------GSSGEIAVIPIVLF------------FGTGLLSTKDFN- 762

  Fly   387 ILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNI-VVQSITFVLANFF 450
                     ..||.::.|..||.||..|...:||.:.|::|:|..|....: .:..|..:|....
Yeast   763 ---------TFPWSIVVLAMGGIALGKAVSSSGLLVTIARALQKKIQNDGVFAILCIFGILMLVV 818

  Fly   451 SAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIVTQYAHIKTKY 515
            ..|.::.|.|.|::|::.|:...|                       |.|..|.:..:.   ...
Yeast   819 GTFVSHTVSAIIIIPLVQEVGDKL-----------------------SDPKAAPILVFG---CAL 857

  Fly   516 FACCGI------VPTIIGISVALVNTNTW 538
            .|.||:      .|.:..||:.....|.|
Yeast   858 LASCGMGLASSGFPNVTAISMTDKKGNRW 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	102/511 (20%)
Indy-2	NP_001027201.1	dass	52..532	CDD:273267	102/508 (20%)
PHO87	NP_009966.2	COG5408	1..334	CDD:227695
PHO87	NP_009966.2	SLC13_permease	487..914	CDD:238535	104/518 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	85	1.000	Inparanoid score	I1587
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.790