DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy-2 and TDT

DIOPT Version :9

Sequence 1:	NP_001027201.1	Gene:	Indy-2 / 3772456	FlyBaseID:	FBgn0260466	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_199567.1	Gene:	TDT / 834806	AraportID:	AT5G47560	Length:	540	Species:	Arabidopsis thaliana

Alignment Length:	525	Identity:	139/525 - (26%)
Similarity:	249/525 - (47%)	Gaps:	50/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 IIIPLITLPILIYGFQTDMAEFKCLWLIVTMALLWITETLPIYVTALFPLVFCPLLGLVNASIVC 90
            ::..::.|.:.:.|.:|..|. ..|.::|.|...|:||.:|:.:|::.||...||.|:..|..|.
plant    53 LLCAVVCLCVDLGGDETTTAR-NMLGVLVWMFAWWLTEAVPMPITSMTPLFLFPLFGISAADDVA 116

  Fly    91 KQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRR---LFVGLMSVSTFMGLWISN 152
            ..|..|.|.:.||..|:||.:|:.|:|.|:||.:..:....|..   |.:|:.:.:.|:.:|:.|
plant   117 NSYMDDVISLVLGSFILALAVEHYNIHRRLALNITLVFCVEPLNAPLLLLGICATTAFVSMWMHN 181

  Fly   153 SAGTAMMCPIVKALVNELDTNKIFPVYMTQEEEPVEEGEPPHPS--KITVAFYAGIAYASSIGGL 215
            .|...||.|:...::..|.::.             ...|..||:  |.:.|...|:.|::::||:
plant   182 VAAAVMMMPVATGILQRLPSSS-------------STTEVVHPAVGKFSRAVVLGVIYSAAVGGM 233

  Fly   216 GTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIPLMVIVNVTLVIIAFLITHMGLFRPNSK 280
            .||.|||.||:..|::...||.:. .|:|:.:.|:..||.:.:.|.|..:..:     ::.|..
plant   234 STLTGTGVNLILVGMWKSYFPEAD-PISFSQWFFFGFPLALCIFVVLWCVLCV-----MYCPKG- 291

  Fly   281 TGKIIAEANTNRKLMEDVLRQRHID-LGPMSCHEIQMAIAFAFMIVLLITRK-PGFVPGWSDLIN 343
            .|:.::.     .|.:..|| |.:| ||||:..|..:...|..::||.:||. ...:|||..:..
plant   292 AGQALSP-----YLHKSHLR-RELDLLGPMNFAEKMVLAVFGGLVVLWMTRNITDDIPGWGRIFA 350

  Fly   344 RKVVGSASGLSFIVLLIFALPTQYTFFKYCCGKGPFTAQAIDAILSWEYVLRNIPWGLLFLLGGG 408
            .: .|..:....:..|:|.:|:...       ||       :.::.|. ..:.:||.::.|||.|
plant   351 GR-AGDGTVSVMMATLLFIIPSNIK-------KG-------EKLMDWN-KCKKLPWNIVLLLGAG 399

  Fly   409 FALAVASRETGLNIMISKAMQVLIGLPNIVVQSITFVLANFFSAFNANVVVANIVLPILCEMSLA 473
            ||:|...|.:||..::||.:..|...|...:.....::|...:.|.:|.....:::|:|.|::..
plant   400 FAIADGVRTSGLAEVLSKGLVFLETAPYWAIAPTVCLIAATITEFTSNNATTTLLVPLLIEIAKN 464

  Fly   474 LELHPLILTLPACLGISMVYFLPVSTPPNAIVTQYAHIKTKYFACCGIVPTIIGISVALVNTNTW 538
            :.:|||:|.:|..:|....:.||..||.|.:.....||:.|.....|:...|.|.....:...|.
plant   465 MGIHPLLLMVPGAIGAQFAFLLPTGTPSNVVGFTTGHIEIKDMIKTGLPLKIAGTIFLSILMPTL 529

  Fly   539 GLIIF 543
            |..:|
plant   530 GAYVF 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	132/489 (27%)
Indy-2	NP_001027201.1	dass	52..532	CDD:273267	131/486 (27%)
TDT	NP_199567.1	CitT	74..529	CDD:223547	132/496 (27%)
TDT	NP_199567.1	SLC13_permease	76..534	CDD:238535	134/499 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	215	1.000	Domainoid score	I747
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I1174
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		otm3220
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.930