Protein Alignment Indy-2 and SLC13A1

DIOPT Version :9

• Sequence 1: NP_001027201.1
• Gene: Indy-2 / 3772456
• FlyBaseID: FBgn0260466
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: XP_011514817.1
• Gene: SLC13A1 / 6561
• HGNCID: 10916
• Length: 651
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 176/645 - (27%)
• Similarity: 297/645 - (46%)
• Gaps: 126/645 - (19%)

  Fly    27 IIPLITLPILIYGFQTDMAEFKCLWLIVTMALLWITETLPIYVTALFPLVFCPLLGLVNASIVCK 91
            ::.|:.|||:::     ..|.:|.:.:..:|..|:||.||:.||||.|.:..|:.|::.:..|..
Human    20 VLVLLPLPIVLH-----TKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVAS 79

  Fly    92 QYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFVGLMSVSTFMGLWISNSAGT 156
            .||.|..::.:|.:.:|..||..|||.||||:::.:||.:|..|.:|.||.:.|:.:|:||::..
Human    80 AYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTA 144

  Fly   157 AMMCPIVKALVNEL-------------------------------------------------DT 172
            ||:.||.:|:|.::                                                 ||
Human   145 AMVMPIAEAVVQQIINAEAEVEATQMTYFNGSTNHGLEIDESVNGHEINERKEKTKPVPGYNNDT 209

  Fly   173 NKI-FPVYMTQEEEPVEEGE-------------------PPHPSKITVAF--------------- 202
            .|| ..|.:.:|||...:..                   ..|....|:.|
Human   210 GKISSKVELEKEEEESNQQRVFTGSWVRKRMKLLLAYTLESHLLNKTLTFGLVIPQVKPFQDVPL 274

  Fly   203 --YAG--------------------IAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFA 245
              .:|                    |||:|:||||.|:.||.|||:|...:..|:|.... :.|.
Human   275 SKNSGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCRC-LNFG 338

  Fly   246 NFMFYSIP-LMVIVNVTLVIIAFLITHMGL-FRPNSKTGKIIAEANTNRKLMEDVLRQRHIDLGP 308
            ::..:|.| .::|:.::.:.:.:|.  :|. |:...|.||   .....:|...:|::|.:..|||
Human   339 SWFTFSFPAALIILLLSWIWLQWLF--LGFNFKEMFKCGK---TKTVQQKACAEVIKQEYQKLGP 398

  Fly   309 MSCHEIQMAIAFAFMIVLLITRKPGFVPGWSDLINRKVVGSASGLS---FIVLLIFALPTQYTFF 370
            :...||...:.|..|.:|..:|.||||||||.|.: :..|.|:..:   .|.||.|.:|.: |..
Human   399 IRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFS-EYPGFATDSTVALLIGLLFFLIPAK-TLT 461

  Fly   371 KYCCGKGPFTAQAIDAILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLP 435
            | ....|...|.....:::|:.....:||.:..|:|||||||....|:||:..|...:..|..||
Human   462 K-TTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLP 525

  Fly   436 NIVVQSITFVLANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTP 500
            ..::..|:.::....:...:|.....:.||||..::.|:.::||.:.:|:.|..|..:.|||:.|
Human   526 AWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANP 590

  Fly   501 PNAIVTQYAHIKTKYFACCGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAKEIKNQT 560
            |||||..|.|:|.......|:...|:|::|.::...||.:.:| :..::|.||..:.|:|
Human   591 PNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMF-DLYTYPSWAPAMSNET 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	162/593 (27%)
		dass	52..532	CDD:273267	162/590 (27%)
SLC13A1	XP_011514817.1	SLC13_permease	41..625	CDD:238535	162/592 (27%)
		CitT	48..633	CDD:223547	163/593 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146942
Domainoid	1	1.000	373	1.000	Domainoid score	I892
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	385	1.000	Inparanoid score	I2041
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8490
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860