Protein Alignment Indy-2 and slc13a1

DIOPT Version :10

• Sequence 1: NP_001027201.1
• Gene: Indy-2 / 3772456
• FlyBaseID: FBgn0260466
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: XP_068073435.1
• Gene: slc13a1 / 387592
• ZFINID: ZDB-GENE-031222-3
• Length: 612
• Species: Danio rerio
• Alignment Length: 622
• Identity: 186/622 - (29%)
• Similarity: 298/622 - (47%)
• Gaps: 87/622 - (13%)

  Fly    14 RCCIFHWRGKASIII---PLITLPILIYGFQTDMAEFKCLWLIVTMALLWITETLPIYVTALFPL 75
            ||   .|.....:||   ||..||:.:. .:|..||  |.::::.||:.|:||.||:.||||.|.
Zfish     5 RC---SWSALKPLIIISTPLAILPLPLV-IKTKEAE--CAYVLILMAVYWMTEVLPLSVTALIPA 63

  Fly    76 VFCPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFVGLM 140
            :..||.|::.:|.|..|||.|..::.||.:.:|..||...||.|||||::..:|.:|..|.:|.|
Zfish    64 LLFPLFGIMKSSQVASQYFKDFHLLLLGVICLATSIEKWGLHRRIALRLVTGLGVNPGMLMLGFM 128

  Fly   141 SVSTFMGLWISNSAGTAMMCPIVKALVNEL-----DTNK-------------------------- 174
            ....|:.:|:||::..||:.|||:|::.::     :.||
Zfish   129 VGCAFLSMWLSNTSTVAMVMPIVEAVIQQVLSASEEANKDHKGALNGISNPALQLEDIEAQHDQS 193

  Fly   175 ----------IFPVYMTQEEEPVEEGEPPHPSK--------ITVAFYAGIAYASSIGGLGTLIGT 221
                      ..|...::|.|..:...||:..|        :.......|||:||||||.||.||
Zfish   194 EKIKSIEAGITEPEPTSEEHETAKAPTPPYSGKYRTREDHMMCKGLSLCIAYSSSIGGLTTLSGT 258

  Fly   222 GTNLVFRGIYTERFPTSTVEITFANFMFYSIPLMVIVNVTLVIIAFLITHMGLFRPNSKTGKIIA 286
            .|||:|.....:.:|..|: :.|.|:....:|:.:|    ::|:::|..|......|.:......
Zfish   259 STNLIFAEYIYQYYPECTI-VNFGNWFVLCLPICII----MLILSWLFLHWMYLGSNFRASLCSR 318

  Fly   287 EANTNRKLMEDVLRQRHIDLGPMSCHEIQMAIAFAFMIVLLITRKPGFVPGWSDLINRKVVGSAS 351
            :.....|:...|||..:..|||:|..||...|.|..|.:|..||.|||:||||.|.:.. .|.|:
Zfish   319 QRTEKEKITARVLRDHYNSLGPISWQEIVTLIIFILMAILWFTRNPGFMPGWSSLFSDN-PGYAT 382

  Fly   352 GLSFIVL---LIFALPTQ---------YTFFKYCCGKGPFTA---------QAIDAILSWEYVLR 395
            ..:..:|   |.|.||:.         .|...:....|..:|         ...:|:::|:....
Zfish   383 DATVALLLGFLFFLLPSHKLNADHYGTTTLKTFSMIGGALSAFLLMIYIFIHLTEALITWKDFQA 447

  Fly   396 NIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQSITFVLANFFSAFNANVVVA 460
            .:||.:..|:|||||||..::.:||:..:::.:..|..||.:...:|..::....:...:|....
Zfish   448 CMPWEISLLVGGGFALAEGTKISGLSSWVAELLTPLGSLPPLATVTIACLIVTSITEVASNAATM 512

  Fly   461 NIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIVTQYAHIKTKYFACCGIVPTI 525
            .|.||||..::.|:.::||.:.:|..|.:|..:.||||.||||||..|.|:.:......|:...:
Zfish   513 TIFLPILAPLAEAIGVNPLYMLIPTALAVSFSFLLPVSNPPNAIVFTYGHLTSMDMVKAGLGVNV 577

  Fly   526 IGISVALVNTNTWGLIIFPESKSFPDWAKEIKNQTKI 562
            |||...|:...|||..:. :..::|||| .:.|.|.:
Zfish   578 IGILTVLLALTTWGTPLL-KLDTYPDWA-PVVNSTGV 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	CitT	102..544	CDD:440239	146/511 (29%)
slc13a1	XP_068073435.1	ArsB_NhaD_permease	<13..163	CDD:473875	58/152 (38%)
		CitT	90..590	CDD:440239	143/505 (28%)