DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Indy-2 and slc13a1

DIOPT Version :9

Sequence 1:	NP_001027201.1	Gene:	Indy-2 / 3772456	FlyBaseID:	FBgn0260466	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_954975.1	Gene:	slc13a1 / 387592	ZFINID:	ZDB-GENE-031222-3	Length:	583	Species:	Danio rerio

Alignment Length:	604	Identity:	184/604 - (30%)
Similarity:	294/604 - (48%)	Gaps:	80/604 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RCCIFHWRGKASIII---PLITLPILIYGFQTDMAEFKCLWLIVTMALLWITETLPIYVTALFPL 75
            ||   .|.....:||   ||..||:.:. .:|..||  |.::::.||:.|:||.||:.||||.|.
Zfish     5 RC---SWSALKPLIIISTPLAILPLPLV-IKTKEAE--CAYVLILMAVYWMTEVLPLSVTALIPA 63

  Fly    76 VFCPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFVGLM 140
            :..||.|::.:|.|..|||.|..::.||.:.:|..||...||.|||||::..:|.:|..|.:|.|
Zfish    64 LLFPLFGIMKSSQVASQYFKDFHLLLLGVICLATSIEKWGLHRRIALRLVTGLGVNPGMLMLGFM 128

  Fly   141 SVSTFMGLWISNSAGTAMMCPIVKALVNEL-----DTNK-------------------------- 174
            ....|:.:|:||::..||:.|||:|::.::     :.||
Zfish   129 VGCAFLSMWLSNTSTVAMVMPIVEAVIQQVLSASEEANKDHKGALNGISNPALQLEDIEAQHDQS 193

  Fly   175 ----------IFPVYMTQEEEPVEEGEPPHPSK--------ITVAFYAGIAYASSIGGLGTLIGT 221
                      ..|...::|.|..:...||:..|        :.......|||:||||||.||.||
Zfish   194 EKIKSIEAGITEPEPTSEEHETAKAPTPPYSGKYRTREDHMMCKGLSLCIAYSSSIGGLTTLSGT 258

  Fly   222 GTNLVFRGIYTERFPTSTVEITFANFMFYSIPLMVIVNVTLVIIAFLITHMGLFRPNSKTGKIIA 286
            .|||:|.....:.:|..|: :.|.|:....:|:.:|    ::|:::|..|......|.:......
Zfish   259 STNLIFAEYIYQYYPECTI-VNFGNWFVLCLPICII----MLILSWLFLHWMYLGSNFRASLCSR 318

  Fly   287 EANTNRKLMEDVLRQRHIDLGPMSCHEIQMAIAFAFMIVLLITRKPGFVPGWSDLINRKVVGSAS 351
            :.....|:...|||..:..|||:|..||...|.|..|.:|..||.|||:||||.|.:.. .|.|:
Zfish   319 QRTEKEKITARVLRDHYNSLGPISWQEIVTLIIFILMAILWFTRNPGFMPGWSSLFSDN-PGYAT 382

  Fly   352 GLSFIVL---LIFALPTQYTFFKYCCGKGPFTAQAIDAILSWEYVLRNIPWGLLFLLGGGFALAV 413
            ..:..:|   |.|.||:.           ...|...:|:::|:.....:||.:..|:|||||||.
Zfish   383 DATVALLLGFLFFLLPSH-----------KLNADHYEALITWKDFQACMPWEISLLVGGGFALAE 436

  Fly   414 ASRETGLNIMISKAMQVLIGLPNIVVQSITFVLANFFSAFNANVVVANIVLPILCEMSLALELHP 478
            .::.:||:..:::.:..|..||.:...:|..::....:...:|.....|.||||..::.|:.::|
Zfish   437 GTKISGLSSWVAELLTPLGSLPPLATVTIACLIVTSITEVASNAATMTIFLPILAPLAEAIGVNP 501

  Fly   479 LILTLPACLGISMVYFLPVSTPPNAIVTQYAHIKTKYFACCGIVPTIIGISVALVNTNTWGLIIF 543
            |.:.:|..|.:|..:.||||.||||||..|.|:.:......|:...:|||...|:...|||..:.
Zfish   502 LYMLIPTALAVSFSFLLPVSNPPNAIVFTYGHLTSMDMVKAGLGVNVIGILTVLLALTTWGTPLL 566

  Fly   544 PESKSFPDWAKEIKNQTKI 562
             :..::|||| .:.|.|.:
Zfish   567 -KLDTYPDWA-PVVNSTGV 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	161/534 (30%)
Indy-2	NP_001027201.1	dass	52..532	CDD:273267	161/531 (30%)
slc13a1	NP_954975.1	ArsB_NhaD_permease	7..565	CDD:304373	176/577 (31%)
slc13a1	NP_954975.1	CitT	14..561	CDD:223547	172/566 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580399
Domainoid	1	1.000	381	1.000	Domainoid score	I793
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1908
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm6448
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.860