DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy-2 and CG7309

DIOPT Version :9

Sequence 1:	NP_001027201.1	Gene:	Indy-2 / 3772456	FlyBaseID:	FBgn0260466	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_609468.4	Gene:	CG7309 / 34509	FlyBaseID:	FBgn0032314	Length:	528	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	129/534 - (24%)
Similarity:	240/534 - (44%)	Gaps:	46/534 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEPGEQRKFVLGRCCIFHWRGKASIIIPLITLPILIYGFQTDMAEFKCLWLIVTMALLWITETL 65
            :.|..::|.|     |.:|::|...:.||::..||||   .|.:...:.::|.:.:.|::|...:
  Fly    14 LEEQDDRRLF-----CKYHYKGVLLLFIPILLAPILI---GTPVLICRFIYLTLCLYLIYILNLM 70

  Fly    66 PIYVTALFPLVFCPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGG 130
            .....|...:||.|:.|:.::..:...|:||.|......:.:.:.::.|.|..|:|..||.:|||
  Fly    71 ARGAAAFIYMVFIPVAGIASSKEISVSYYTDLIFFVYSAIFMGIMMDSSKLSDRLAFIVISLVGG 135

  Fly   131 SPRRLFVGLMSVSTFMGLWISNSAGTAMMCPIVKALVNELDTNKIFPVYMTQEEEPVEEGEPPHP 195
            |.:.|.:.|...:..:.:.::.:...|....:.:|::.|.|...:  :.:..||:|.|.|..|:|
  Fly   136 SLKFLQIFLTIAAAIVSILVNPTISAAFWMKVSQAVMVEYDNGGL--IKLNSEEKPYEIGSKPYP 198

  Fly   196 SKITVAFYAGIAYASSI-GGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIPLMVIVN 259
            ::..:..|....||:|: ..|..::..      .|:.::.|..|...:.....|.....:.::|.
  Fly   199 TRPVIGIYLTCCYAASLAASLSPIVNP------NGVISDGFGGSLTVLEIGMLMAGPALMGLVVM 257

  Fly   260 VTLVIIAFLITHMGLFRPNSKTGKIIAEANTNRKLMEDVLRQRHIDLGPMSCHEIQMAIAFAFMI 324
            :..:.:.||    ||...:.|  :.:||....:...:....:|...|||...:.|........|.
  Fly   258 IFWLQVLFL----GLLGGSVK--RDLAEMAGAKAGFKQTASERKQALGPWGIYPILALSLILLMF 316

  Fly   325 VLLITRKPGFVPGWSDLINRKVVGSASGLSF----IVLLIFALPTQYTFFKYCCGKGPFTAQAID 385
            :|:.||||....|| |.||.|   :.||||.    :.:|.||:|..|.|.:|...:.|......:
  Fly   317 LLVATRKPRIFTGW-DSINYK---AESGLSVAGIGMSILFFAIPANYIFCRYYVCRQPEKEGPAN 377

  Fly   386 AILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQSITFV----L 446
            ::|.|:.|..|.||..:|:||..|:.:.:|...|||..::.:|    ...|......:|:    |
  Fly   378 SLLGWKAVNNNTPWAEIFMLGAAFSFSYSSAVCGLNTYLADSM----NSDNKGFNMKSFICGALL 438

  Fly   447 ANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIVTQYAHI 511
            ...::..:....||.:.||.:.....:       .:||....:...:.||||:|.|.||..:.::
  Fly   439 GTLWTTLSPATTVAKLALPTMVTAGNS-------FSLPFATALHNQFLLPVSSPANTIVAGWGNV 496

  Fly   512 KTKYFACCGIVPTI 525
            :...|...|.:.|:
  Fly   497 RPFQFLLGGSILTL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	116/485 (24%)
Indy-2	NP_001027201.1	dass	52..532	CDD:273267	116/483 (24%)
CG7309	NP_609468.4	CitT	31..523	CDD:223547	123/512 (24%)
CG7309	NP_609468.4	ArsB_NhaD_permease	76..523	CDD:304373	113/464 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448682
Domainoid	1	1.000	122	1.000	Domainoid score	I1235
eggNOG	1	0.900	-	-		E1_COG0471
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	85	1.000	Inparanoid score	I1587
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890