Protein Alignment Indy-2 and SLC13A5

DIOPT Version :10

• Sequence 1: NP_001027201.1
• Gene: Indy-2 / 3772456
• FlyBaseID: FBgn0260466
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_808218.1
• Gene: SLC13A5 / 284111
• HGNCID: 23089
• Length: 568
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 201/564 - (35%)
• Similarity: 300/564 - (53%)
• Gaps: 44/564 - (7%)

  Fly    27 IIPLITLPILIYGFQTDMAEF-KCLWLIVTMALLWITETLPIYVTALFPLVFCPLLGLVNASIVC 90
            :.||:.||::|    ...|:| :|.::|:.||:.|.||.:|:.||:|.|::..||..::::..||
Human    19 VTPLLLLPLVI----LMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVC 79

  Fly    91 KQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFVGLMSVSTFMGLWISNSAG 155
            .||..||.::||||||||:.:|..|||.|||||.:..||..|.||.:|.|.|:..:.:||||:|.
Human    80 VQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTAT 144

  Fly   156 TAMMCPIVKALVNELDTN----------------KIFPVYMTQEEEP-VEEGEPPHPSKITVAFY 203
            ||||.|||:|::.:::..                |..|......|.| :.:.|.....::..|..
Human   145 TAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQERKRLCKAMT 209

  Fly   204 AGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIPLMVIVNVTLVIIAFL 268
            ..|.||:||||..||.|||.|:|..|...|.||.|...:.||::..::.|.|::    :::.|:|
Human   210 LCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLV----MLLFAWL 270

  Fly   269 ITHMGLFRPN-SKTGKIIAEANTNRKLMEDVLRQRHIDLGPMSCHEIQMAIAFAFMIVLLITRKP 332
            .......|.| .|:.....|:..|.|....||::.:..|||:|..||.:.|.|..:::|..:|.|
Human   271 WLQFVYMRFNFKKSWGCGLESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDP 335

  Fly   333 GFVPGWSDLI----NRKVVGSASGLSFIVLLIFALPTQYTFFKYCC-----GKGPFTAQAIDAIL 388
            ||:|||..:.    ..|.|..|:...|:..|:|.:|:|...|.:..     .|.||..   ..:|
Human   336 GFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNFRSQTEEERKTPFYP---PPLL 397

  Fly   389 SWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQSITFVLANFFSAF 453
            .|:.....:|||::.|||||||||..|..:||::.:.|.|:.|..:|...:..|..:|...|:..
Human   398 DWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTEC 462

  Fly   454 NANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIVTQYAHIKTKYFAC 518
            .:||....:.|||...||.::.|:||.:.||..|..|..:.|||:|||||||..|.|:|......
Human   463 TSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVK 527

  Fly   519 CGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAKEIKNQTKI 562
            .|::..|||:....:..||||..|| :...|||||    |.|.|
Human   528 TGVIMNIIGVFCVFLAVNTWGRAIF-DLDHFPDWA----NVTHI 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	CitT	102..544	CDD:440239	164/468 (35%)
SLC13A5	NP_808218.1	CitMHS	<11..164	CDD:460985	65/148 (44%)
		CitT	91..547	CDD:440239	160/462 (35%)