DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy-2 and SLC13A5

DIOPT Version :9

Sequence 1:	NP_001027201.1	Gene:	Indy-2 / 3772456	FlyBaseID:	FBgn0260466	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_808218.1	Gene:	SLC13A5 / 284111	HGNCID:	23089	Length:	568	Species:	Homo sapiens

Alignment Length:	564	Identity:	201/564 - (35%)
Similarity:	300/564 - (53%)	Gaps:	44/564 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IIPLITLPILIYGFQTDMAEF-KCLWLIVTMALLWITETLPIYVTALFPLVFCPLLGLVNASIVC 90
            :.||:.||::|    ...|:| :|.::|:.||:.|.||.:|:.||:|.|::..||..::::..||
Human    19 VTPLLLLPLVI----LMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVC 79

  Fly    91 KQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFVGLMSVSTFMGLWISNSAG 155
            .||..||.::||||||||:.:|..|||.|||||.:..||..|.||.:|.|.|:..:.:||||:|.
Human    80 VQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTAT 144

  Fly   156 TAMMCPIVKALVNELDTN----------------KIFPVYMTQEEEP-VEEGEPPHPSKITVAFY 203
            ||||.|||:|::.:::..                |..|......|.| :.:.|.....::..|..
Human   145 TAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQERKRLCKAMT 209

  Fly   204 AGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIPLMVIVNVTLVIIAFL 268
            ..|.||:||||..||.|||.|:|..|...|.||.|...:.||::..::.|.|::    :::.|:|
Human   210 LCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLV----MLLFAWL 270

  Fly   269 ITHMGLFRPN-SKTGKIIAEANTNRKLMEDVLRQRHIDLGPMSCHEIQMAIAFAFMIVLLITRKP 332
            .......|.| .|:.....|:..|.|....||::.:..|||:|..||.:.|.|..:::|..:|.|
Human   271 WLQFVYMRFNFKKSWGCGLESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDP 335

  Fly   333 GFVPGWSDLI----NRKVVGSASGLSFIVLLIFALPTQYTFFKYCC-----GKGPFTAQAIDAIL 388
            ||:|||..:.    ..|.|..|:...|:..|:|.:|:|...|.:..     .|.||..   ..:|
Human   336 GFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNFRSQTEEERKTPFYP---PPLL 397

  Fly   389 SWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQSITFVLANFFSAF 453
            .|:.....:|||::.|||||||||..|..:||::.:.|.|:.|..:|...:..|..:|...|:..
Human   398 DWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTEC 462

  Fly   454 NANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIVTQYAHIKTKYFAC 518
            .:||....:.|||...||.::.|:||.:.||..|..|..:.|||:|||||||..|.|:|......
Human   463 TSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVK 527

  Fly   519 CGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAKEIKNQTKI 562
            .|::..|||:....:..||||..|| :...|||||    |.|.|
Human   528 TGVIMNIIGVFCVFLAVNTWGRAIF-DLDHFPDWA----NVTHI 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	179/509 (35%)
Indy-2	NP_001027201.1	dass	52..532	CDD:273267	179/506 (35%)
SLC13A5	NP_808218.1	ArsB_NhaD_permease	31..552	CDD:419678	186/527 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146948
Domainoid	1	1.000	373	1.000	Domainoid score	I892
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	385	1.000	Inparanoid score	I2041
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8490
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.900