Protein Alignment Indy-2 and SLC13A4

DIOPT Version :10

• Sequence 1: NP_001027201.1
• Gene: Indy-2 / 3772456
• FlyBaseID: FBgn0260466
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_001305121.1
• Gene: SLC13A4 / 26266
• HGNCID: 15827
• Length: 627
• Species: Homo sapiens
• Alignment Length: 640
• Identity: 179/640 - (27%)
• Similarity: 302/640 - (47%)
• Gaps: 113/640 - (17%)

  Fly     8 RKFVLGRCCIFHWRGKASIIIPLITLPILIYGFQTDMAEFKCLWLIVTMALLWITETLPIYVTAL 72
            ||.:|..|            :||:.||:.:.   ...:|..|.::::..|:.|::|.:|:...||
Human    11 RKLLLVVC------------VPLLLLPLPVL---HPSSEASCAYVLIVTAVYWVSEAVPLGAAAL 60

  Fly    73 FPLVFCPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFV 137
            .|....|..|::.::.|..:||.:|.::.:|.:.||..:|..|||.|||||::.:.|..|..|.:
Human    61 VPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLL 125

  Fly   138 GLMSVSTFMGLWISNSAGTAMMCPIVKALVNEL----DTNKIFPVYMTQEEEPV----------- 187
            ..|..:|.:.:|:||::.|||:.|||:|::.||    |...:.....|:|.||:
Human   126 CFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELVSAEDEQLVAGNSNTEEAEPISLDVKNSQPSL 190

  Fly   188 --------------------------------------EEGEPPHPSK----------------- 197
                                                  .:|:..|||:
Human   191 ELIFVNEDRSNADLTTLMHNENLNGVPSITNPIKTANQHQGKKQHPSQEKPQVLTPSPRKQKLNR 255

  Fly   198 ---------ITVAFYAGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIP 253
                     |.......|:|:::||||.|:|||.|:|:|...:..::|.:.| :.|..:..:|.|
Human   256 KYRSHHDQMICKCLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQYPAAEV-VNFGTWFLFSFP 319

  Fly   254 LMVIVNVTLVIIAFLITHMGLFRPNSK-TGKIIAEANTNR-KLMEDVLRQRHIDLGPMSCHEIQM 316
            :.:|    ::::::...|......|.| |..:..:..|.| :|.|..:::.:..||.:|..|:..
Human   320 ISLI----MLVVSWFWMHWLFLGCNFKETCSLSKKKKTKREQLSEKRIQEEYEKLGDISYPEMVT 380

  Fly   317 AIAFAFMIVLLITRKPGFVPGWSDLINRKVVGSASGLS-FIVLLIFALPTQYTFFKYCCGK---G 377
            ...|..|.||..||:|||||||.....:|...:.:.:| |:..|:|.:|.:    |.|.||   |
Human   381 GFFFILMTVLWFTREPGFVPGWDSFFEKKGYRTDATVSVFLGFLLFLIPAK----KPCFGKKNDG 441

  Fly   378 PFTAQAI--DAILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQ 440
            .....::  :.|::|:...:.:||.::.|:|||:|||..|:.:||:..|...|..|..||...|.
Human   442 ENQEHSLGTEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVT 506

  Fly   441 SITFVLANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIV 505
            .:..:|.:..:.|.:|.....|.|||||.:|..|.::||...:|..:.||....|||..||||||
Human   507 LLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPNAIV 571

  Fly   506 TQYAHIKTKYFACCGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAKEIKNQT 560
            ..|.|.:.|.....|:...:||:.:.:|..||||:.:| ...::|.||: :.|.|
Human   572 FSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLF-HLDTYPAWAR-VSNIT 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	CitT	102..544	CDD:440239	150/528 (28%)
SLC13A4	NP_001305121.1	CitT	90..604	CDD:440239	147/522 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..253		4/34 (12%)