Protein Alignment Indy-2 and SLC13A4

DIOPT Version :9

• Sequence 1: NP_001027201.1
• Gene: Indy-2 / 3772456
• FlyBaseID: FBgn0260466
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_001305121.1
• Gene: SLC13A4 / 26266
• HGNCID: 15827
• Length: 627
• Species: Homo sapiens
• Alignment Length: 640
• Identity: 179/640 - (27%)
• Similarity: 302/640 - (47%)
• Gaps: 113/640 - (17%)

  Fly     8 RKFVLGRCCIFHWRGKASIIIPLITLPILIYGFQTDMAEFKCLWLIVTMALLWITETLPIYVTAL 72
            ||.:|..|            :||:.||:.:.   ...:|..|.::::..|:.|::|.:|:...||
Human    11 RKLLLVVC------------VPLLLLPLPVL---HPSSEASCAYVLIVTAVYWVSEAVPLGAAAL 60

  Fly    73 FPLVFCPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFV 137
            .|....|..|::.::.|..:||.:|.::.:|.:.||..:|..|||.|||||::.:.|..|..|.:
Human    61 VPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLL 125

  Fly   138 GLMSVSTFMGLWISNSAGTAMMCPIVKALVNEL----DTNKIFPVYMTQEEEPV----------- 187
            ..|..:|.:.:|:||::.|||:.|||:|::.||    |...:.....|:|.||:
Human   126 CFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELVSAEDEQLVAGNSNTEEAEPISLDVKNSQPSL 190

  Fly   188 --------------------------------------EEGEPPHPSK----------------- 197
                                                  .:|:..|||:
Human   191 ELIFVNEDRSNADLTTLMHNENLNGVPSITNPIKTANQHQGKKQHPSQEKPQVLTPSPRKQKLNR 255

  Fly   198 ---------ITVAFYAGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIP 253
                     |.......|:|:::||||.|:|||.|:|:|...:..::|.:.| :.|..:..:|.|
Human   256 KYRSHHDQMICKCLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQYPAAEV-VNFGTWFLFSFP 319

  Fly   254 LMVIVNVTLVIIAFLITHMGLFRPNSK-TGKIIAEANTNR-KLMEDVLRQRHIDLGPMSCHEIQM 316
            :.:|    ::::::...|......|.| |..:..:..|.| :|.|..:::.:..||.:|..|:..
Human   320 ISLI----MLVVSWFWMHWLFLGCNFKETCSLSKKKKTKREQLSEKRIQEEYEKLGDISYPEMVT 380

  Fly   317 AIAFAFMIVLLITRKPGFVPGWSDLINRKVVGSASGLS-FIVLLIFALPTQYTFFKYCCGK---G 377
            ...|..|.||..||:|||||||.....:|...:.:.:| |:..|:|.:|.:    |.|.||   |
Human   381 GFFFILMTVLWFTREPGFVPGWDSFFEKKGYRTDATVSVFLGFLLFLIPAK----KPCFGKKNDG 441

  Fly   378 PFTAQAI--DAILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQ 440
            .....::  :.|::|:...:.:||.::.|:|||:|||..|:.:||:..|...|..|..||...|.
Human   442 ENQEHSLGTEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVT 506

  Fly   441 SITFVLANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIV 505
            .:..:|.:..:.|.:|.....|.|||||.:|..|.::||...:|..:.||....|||..||||||
Human   507 LLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPNAIV 571

  Fly   506 TQYAHIKTKYFACCGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAKEIKNQT 560
            ..|.|.:.|.....|:...:||:.:.:|..||||:.:| ...::|.||: :.|.|
Human   572 FSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLF-HLDTYPAWAR-VSNIT 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	158/569 (28%)
		dass	52..532	CDD:273267	158/566 (28%)
SLC13A4	NP_001305121.1	SLC13_permease	38..605	CDD:238535	161/575 (28%)
		dass	40..604	CDD:273267	160/572 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..253		4/34 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146951
Domainoid	1	1.000	373	1.000	Domainoid score	I892
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	385	1.000	Inparanoid score	I2041
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8490
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860