DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Indy-2 and SPBC3B8.04c

DIOPT Version :9

Sequence 1:	NP_001027201.1	Gene:	Indy-2 / 3772456	FlyBaseID:	FBgn0260466	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_596410.1	Gene:	SPBC3B8.04c / 2540279	PomBaseID:	SPBC3B8.04c	Length:	867	Species:	Schizosaccharomyces pombe

Alignment Length:	554	Identity:	127/554 - (22%)
Similarity:	227/554 - (40%)	Gaps:	123/554 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FVLGRCCIFHWRGKASIIIPLITLPILIYGFQT--DMAEFKCLWLIVTMALLWITETLPIYVTAL 72
            |.:.||   .:....:.:|.:|.:.||:..|..  :..:..||.|:|.::|||.||.:|::||:.
pombe   396 FRIPRC---FFNSTIATLITIIVIFILLLSFPVIDNREQNNCLALLVMVSLLWATEAIPLFVTSF 457

  Fly    73 ---FPLVF---------CPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVI 125
               |..||         .||.|..:..::....:..|||:.|||..:|..:...::..|:|..::
pombe   458 LVPFMTVFLKILRDENGSPLSGKESTKVIFSSMWNPTIVLLLGGFTIAAALSKYHIAKRLATSIL 522

  Fly   126 RIVGGSPRRLFVGLMSVSTFMGLWISNSAGTAMMCPIVKALVNELDTNKIFPVYMTQEEEPVEEG 190
            ...|..||.:.:..|.|:.|..:||||.|...:...|::.|:..|.....|
pombe   523 AHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLRNLPAESDF-------------- 573

  Fly   191 EPPHPSKITVAFYAGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIPLM 255
                 :||.:   .|||.||::||:.:.|.:..|:|       ..........:..:...|||:.
pombe   574 -----AKILI---VGIALASNVGGIASPISSPQNIV-------ALQNMDPAAGWGEWFAVSIPVS 623

  Fly   256 VIVNVTLVIIAFLITHMGLFRPNSKTGKIIAEANTNRKLMEDVLRQRHIDLGPM-SCHEIQMAIA 319
            ::   .:..|.||:: .||                        |:..||.|..: |..:....:.
pombe   624 LL---CIFSIWFLLS-FGL------------------------LKDEHITLAKIRSTKDTFTGVQ 660

  Fly   320 FAFMIVLLITRKPGFVPGWSDLINRK---VVGSASGLSFIVLLIFALPTQYTFFKYCCGKGPFTA 381
            :...||.:     |.:..|  .:.|:   |.|....::.:.:::|            .|.|..|.
pombe   661 WFISIVTI-----GTIVLW--CLERRFDEVFGDMGVIALVPIIVF------------FGTGLLTK 706

  Fly   382 QAIDAILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPN-----IVVQS 441
            :..:          |..|.::.|..||.||......:||..:|:..:...:...|     ::..:
pombe   707 EDFN----------NFLWTVIVLAMGGVALGKVVSSSGLLELIALKIGNAVSSLNTFRVLLIFSA 761

  Fly   442 ITFVLANFFSAFNANVVVANIVLPILCEMSLAL-ELHPLILTLPACLGISMVYFLPVSTPPN--A 503
            :|.|:::|.|    ::|.|.:||||:.|:...| :.||.:..|.:.:..|:...||.|..||  |
pombe   762 LTLVVSSFIS----HIVAAMVVLPIVHEVGSRLADPHPRLFVLASGMMCSLAMALPTSGFPNMTA 822

  Fly   504 IVTQ----YAHIKTKYFACCGIVPTIIGISVALV 533
            |:.:    ..::|...|...||..|:|...:.|:
pombe   823 IMMENEAGKRYLKVSDFLKAGIPATLISFVILLL 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	117/510 (23%)
Indy-2	NP_001027201.1	dass	52..532	CDD:273267	116/507 (23%)
SPBC3B8.04c	NP_596410.1	COG5408	1..301	CDD:227695
		SPX_PHO87_PHO90_like	2..282	CDD:269899
		CitT	409..861	CDD:223547	124/538 (23%)
		SLC13_permease	435..858	CDD:238535	118/512 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	130	1.000	Domainoid score	I1327
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I1393
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860