Protein Alignment Indy-2 and Slc13a4

DIOPT Version :9

• Sequence 1: NP_001027201.1
• Gene: Indy-2 / 3772456
• FlyBaseID: FBgn0260466
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_766480.1
• Gene: Slc13a4 / 243755
• MGIID: 2442367
• Length: 625
• Species: Mus musculus
• Alignment Length: 642
• Identity: 192/642 - (29%)
• Similarity: 308/642 - (47%)
• Gaps: 112/642 - (17%)

  Fly     6 EQRKFVLGRCCIFHWRGKASIIIPLITLPI-LIYGFQTDMAEFKCLWLIVTMALLWITETLPIYV 69
            :.||.:|..|            :||:.||: .||    ..:|..|.::::..|:.|::|.:|:..
Mouse     9 QARKLLLVIC------------VPLLLLPLPTIY----PTSEAACAYVLLVTAVYWVSEAVPLGA 57

  Fly    70 TALFPLVFCPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRR 134
            .||.|....|..|::.:|.|..:||.:|.::.:|.:.||..:|..|||.|||||::.:.|..|..
Mouse    58 AALVPAFLYPFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGM 122

  Fly   135 LFVGLMSVSTFMGLWISNSAGTAMMCPIVKALVNE--------------------LDTNK----- 174
            |.:..|..:|.:.:|:||::.|||:.|||:|::.|                    ||.|.
Mouse   123 LLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELINAEEEQLAAGTEEAELMGLDVNNRQTSM 187

  Fly   175 --IF----------------------PV----------YMTQEEEPVEE--GEPP---------- 193
              ||                      |:          ...::::|.:|  |.|.
Mouse   188 ELIFVNEDTSAADFTSLMQSKNLNGVPMVTKSINTANQQQQKKQQPSQEKPGVPTPSSKTQELNK 252

  Fly   194 ------HPSKITVAFYAGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSI 252
                  |...|.......|:||::||||.|:|||.|:|:|...:..::|.:.| :.|..:..:|.
Mouse   253 KKYRSHHDQMICKCLSLSISYAATIGGLTTIIGTSTSLIFLEHFNNQYPAAEV-VNFGTWFLFSF 316

  Fly   253 PLMVIVNVTLVIIAFLITHMGLFRPNSKTGKIIAEANTNR-KLMEDVLRQRHIDLGPMSCHEIQM 316
            |:.:|:   ||:..|.|..:.|.....:|..:..:..|.| :|.|..:|:.:..||.:|..|:..
Mouse   317 PISLIM---LVVSWFWIHWLFLGCNFKETCSLSKKKKTRREELSEKRIREEYEKLGDISYPEMVT 378

  Fly   317 AIAFAFMIVLLITRKPGFVPGWSDLINRKVVGSASGLS-FIVLLIFALPTQYTFFKYCCGK---- 376
            |..|..|.||..||:|||||||.....:|...:.:.:| |:..|:|.:|.:    |.|.||
Mouse   379 AFFFILMTVLWFTREPGFVPGWDSFFEKKGYRTDATVSVFLGFLLFLIPAK----KPCFGKKSDG 439

  Fly   377 -GPFTAQAIDAILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQ 440
             |...::.|:.|::|:...:.:||.::.|:|||:|||..|:.:||:..|...|..|..||...:.
Mouse   440 TGQEASKGIEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAIT 504

  Fly   441 SITFVLANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIV 505
            .:..||.:..:.|.:|.....|.|||||.:|..|.::||...:|..:.||....|||..||||||
Mouse   505 LLACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNPPNAIV 569

  Fly   506 TQYAHIKTKYFACCGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAK--EIKNQT 560
            ..|.|.:.|.....|:...:||:.:.:|..||||:.:| ...:||.|||  .|.:||
Mouse   570 FSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLF-HLDAFPAWAKVSNITDQT 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	166/566 (29%)
		dass	52..532	CDD:273267	166/563 (29%)
Slc13a4	NP_766480.1	ArsB_NhaD_permease	31..607	CDD:304373	173/583 (30%)
		dass	40..602	CDD:273267	168/569 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836896
Domainoid	1	1.000	383	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1967
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8724
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.860