DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Indy-2 and Slc13a5

DIOPT Version :9

Sequence 1:	NP_001027201.1	Gene:	Indy-2 / 3772456	FlyBaseID:	FBgn0260466	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_017170015.1	Gene:	Slc13a5 / 237831	MGIID:	3037150	Length:	610	Species:	Mus musculus

Alignment Length:	546	Identity:	174/546 - (31%)
Similarity:	284/546 - (52%)	Gaps:	47/546 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PGEQRKFVL-----GRCCIFHWRGKASIII-PLITLPILIYGFQTDMAEFKCLWLIVTMALLWIT 62
            |||..:...     .:.|:..::..|.::. |::.||::|. .....|  :|.::||.||:.|.|
Mouse    27 PGESSQSPFHAMDSAKTCVTKFKSFAILLFTPILMLPLVIL-IPDKFA--RCAYVIVIMAVYWCT 88

  Fly    63 ETLPIYVTALFPLVFCPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRI 127
            :.:|:.||:|.|::..|||.::::..||.||..||.::|||.||||:.:|...||.|:|||::..
Mouse    89 DVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMKDTNMLFLGSLIVAVAVERWKLHKRVALRMLLF 153

  Fly   128 VGGSPRRLFVGLMSVSTFMGLWISNSAGTAMMCPIVKALVNE-----------------LDTNKI 175
            ||..|.||.:|.|.|:.|:.:||||:|.||||.|||:|::.:                 ||.||.
Mouse   154 VGTKPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAANTAVEASLGTLELLDKNKT 218

  Fly   176 FPVYMTQ---EEEPVEEGEPPHPSKITVAFYAGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPT 237
            ..:..:|   |:..|:|.|......:..|.:..:.|::||||..||.|||.|:|..|...|.||.
Mouse   219 SELPGSQVVFEDPNVQEQEDEETKNMYKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELFPD 283

  Fly   238 STVEITFANFMFYSIPLMVIVNVTLVIIAFLITHMGLFRPNSKTGKIIA--EANTNRKLMEDVLR 300
            |...:.:|::..::.|.||:    ::::|:|.......|.|.|...|..  :.....|:...||.
Mouse   284 SKDVLNYASWFGFAFPNMVM----MLVLAWLWLQCLYMRHNLKKTCICCGEKKRDTEKIAYKVLN 344

  Fly   301 QRHIDLGPMSCHEIQMAIAFAFMIVLLITRKPGFVPGWSDLI----NRKVVGSASGLSFIVLLIF 361
            :.:..||.:|..|..:...|..:::|..:|.|||:|||....    |...:..|:...|:.:|:|
Mouse   345 EEYQKLGSLSYPECNVLFCFTLLVILWFSRDPGFMPGWLSFAWVEGNTVHITDATVAIFVAILLF 409

  Fly   362 ALPTQYTFFKYCC-----GKGPFTAQAIDAILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLN 421
            .:|:|...|.:..     .|.||..   .|:|.|:.....:||.::.|||||||:|.....:||:
Mouse   410 IIPSQKPKFNFSSQTEEERKTPFYP---PALLDWKVAQEKVPWDIVLLLGGGFAMAKGCETSGLS 471

  Fly   422 IMISKAMQVLIGLPNIVVQSITFVLANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPAC 486
            ..::..|:.|..:...|:..|...|....:...:||....:.|||...|:.::.:|||.:.:|..
Mouse   472 KWMAAQMEPLRLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCT 536

  Fly   487 LGISMVYFLPVSTPPNAIVTQYAHIK 512
            :..|:.:.|||:|||||||..|.|::
Mouse   537 MSASLAFMLPVATPPNAIVFAYGHLR 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	163/494 (33%)
Indy-2	NP_001027201.1	dass	52..532	CDD:273267	163/492 (33%)
Slc13a5	XP_017170015.1	ArsB_NhaD_permease	50..566	CDD:389757	170/523 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836890
Domainoid	1	1.000	383	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1967
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8724
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900