DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy-2 and Slc13a2

DIOPT Version :9

Sequence 1:	NP_001027201.1	Gene:	Indy-2 / 3772456	FlyBaseID:	FBgn0260466	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_071856.1	Gene:	Slc13a2 / 20500	MGIID:	1276558	Length:	586	Species:	Mus musculus

Alignment Length:	579	Identity:	214/579 - (36%)
Similarity:	315/579 - (54%)	Gaps:	65/579 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WRGKASIII---P--LITLPILIYGFQTDMAEFKCLWLIVTMALLWITETLPIYVTALFPLVFCP 79
            |..::.:|:   |  |:.||:::   ||  .|..|.:.|:.|||||.||.||:.||||||::..|
Mouse     9 WAYRSYLIVLCLPIFLLPLPLIV---QT--KEAYCAYSIILMALLWCTEALPLAVTALFPIILFP 68

  Fly    80 LLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFVGLMSVST 144
            |:|::.||.||.:||.||.::|:|||:||:.:|:.|||.||||.|:.|:|..|..|.:|.|.|:.
Mouse    69 LMGIMEASKVCLEYFKDTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVRPALLLLGFMLVTA 133

  Fly   145 FMGLWISNSAGTAMMCPIVKALVNEL-------DTNKIFPVYMTQEEEPVEE------------- 189
            |:.:||||:|.||||.||..|::.:|       :.....|.:..||..|.:|
Mouse   134 FLSMWISNTATTAMMLPIGYAVLEQLQGSQKDVEEGNSNPSFELQEASPQKEETKLDNGQAVSVS 198

  Fly   190 GEP-PHPSKITVAFYAG----IAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMF 249
            .|| ...:|....|..|    |.|::||||:.||.||..|||.:|.....||.::..:.||::..
Mouse   199 SEPRAQKTKEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFPENSNVVNFASWFG 263

  Fly   250 YSIPLMVIVNVTLVIIAFL---ITHMGL-FRPNSKTGKIIAEANTNRKLME-DVLRQRHIDLGPM 309
            ::.|.|||    |:::|:|   :..:|: ||.|...|    |....||... .|::.:|..||||
Mouse   264 FAFPTMVI----LLLLAWLWLQVLFLGVNFRKNFGFG----EGEEERKQAAFQVIKTQHRLLGPM 320

  Fly   310 SCHEIQMAIAFAFMIVLLITRKPGFVPGWSD--LINRK---VVGSASGLSFIVLLIFALPTQYTF 369
            |..|..:...|..::||..||:|||.|||.|  ..|:|   :|...:...||.|::|.:|::..
Mouse   321 SFAEKAVTFLFVLLVVLWFTREPGFFPGWGDTAFANKKGQSMVSDGTVAIFISLIMFIIPSKIP- 384

  Fly   370 FKYCCG-----KGPFTAQAIDAILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQ 429
                 |     |.|...:|..|||:|:.|...:||.:|.|||||||||..|.|:||:..:...:.
Mouse   385 -----GLTEDPKKPGKLKAPPAILTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLT 444

  Fly   430 VLIGLPNIVVQSITFVLANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYF 494
            .|..:|......|..:|...|:...:||....:.||||..|:.|:.||||.:.||..|..|:.:.
Mouse   445 PLQHVPPSATVLILSLLVAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFM 509

  Fly   495 LPVSTPPNAIVTQYAHIKTKYFACCGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWA 553
            |||:|||||||..:..:|....|..|.:..|||:....::.|:|.:.|| :..:||.||
Mouse   510 LPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSWSIPIF-KLDTFPTWA 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	196/522 (38%)
Indy-2	NP_001027201.1	dass	52..532	CDD:273267	196/519 (38%)
Slc13a2	NP_071856.1	ArsB_NhaD_permease	6..560	CDD:304373	210/570 (37%)
		dass	43..553	CDD:273267	196/523 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..209		8/43 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836893
Domainoid	1	1.000	383	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1967
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8724
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900