DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy-2 and slc13a5b

DIOPT Version :9

Sequence 1:	NP_001027201.1	Gene:	Indy-2 / 3772456	FlyBaseID:	FBgn0260466	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_001345110.4	Gene:	slc13a5b / 100006328	ZFINID:	ZDB-GENE-130530-605	Length:	580	Species:	Danio rerio

Alignment Length:	593	Identity:	210/593 - (35%)
Similarity:	311/593 - (52%)	Gaps:	71/593 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WRGKASIII---PLITLPILIYGFQTDMAEFKCLWLIVTMALLWITETLPIYVTALFPLVFCPLL 81
            |..|..|::   |||.||:.:.   ....|..|.::|:.||:.|.||.||:.||:|.|.|..|:|
Zfish     9 WNLKNGIVLFFTPLILLPLPLV---ISTREASCAYVIILMAVYWCTEALPLAVTSLLPAVLFPML 70

  Fly    82 GLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFVGLMSVSTFM 146
            |::.:.:||.||..||.::|:|||:||:.:|:.|||.||||||:.|||..|..|.:|.|.|:.|:
Zfish    71 GIMQSKMVCMQYLKDTNMLFVGGLMVAVAVEHWNLHKRIALRVLLIVGVRPALLMLGFMGVTAFL 135

  Fly   147 GLWISNSAGTAMMCPIVKALVNELDTNKIFPVYMT--QEEEPVEEGEPPHPSK------------ 197
            .:||||:|.||||.|||:|::.:|:..:..|:.||  .|.....|.|..|.:|
Zfish   136 SMWISNTATTAMMVPIVQAVLEQLNKQETEPLQMTCGVERPRTPEAEYKHAAKDRDRQVVLRMLD 200

  Fly   198 -------------------ITVAFYAGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEIT 243
                               :|:.    :.||:|:||..||.|||.|||.:|...:.||.:...|.
Zfish   201 VSPEVRQKELAEKRHMAKGMTLC----VCYAASVGGTATLTGTGPNLVLKGQMNQLFPENGDVIN 261

  Fly   244 FANFMFYSIPLMVIVNVTLVIIAFLITHMGLFRPNS------KTGKIIAEANTNRKLMEDVLRQR 302
            ||::..::.|.|:|: :|:..:......||.....:      |:.|.||..|        |:|::
Zfish   262 FASWFGFAFPNMIIM-LTIAWLYLQFIFMGFNIRKTWGCGAVKSEKEIAAYN--------VIREQ 317

  Fly   303 HIDLGPMSCHEIQMAIAFAFMIVLLITRKPGFVPGWSD---LINRKVVGSASGLSFIVLLIFALP 364
            |:.||||...|:.:...|:.::.|..||.||||.||:.   .|..:.|..|:...||.:|:|.||
Zfish   318 HLQLGPMCFGELSVLALFSLLVALWFTRDPGFVAGWATHTFNIEAEYVTDATVAVFIAMLLFVLP 382

  Fly   365 TQYTFFKYCCGKGPFTAQAID-----AILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMI 424
            ::.....:....|..|.....     |:|||:...:.:||.::.|||||||||..|.|:||:..:
Zfish   383 SKPPQLCFSSSTGSETESQRSSAPGTALLSWKVAQKKLPWNIVLLLGGGFALAKGSEESGLSRWL 447

  Fly   425 SKAMQVLIGLPNIVVQSITFVLANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGI 489
            ...:..|..:|...|..|..:|...|:...:||..|.:.||:|..||.::.::||.:.:|..|..
Zfish   448 GNQLTPLHSIPPWAVVIILCLLIAIFTECTSNVATATLFLPVLASMSQSVGINPLYIMVPCTLSA 512

  Fly   490 SMVYFLPVSTPPNAIVTQYAHIKTKYFACCGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAK 554
            |..:.|||:|||||||..|.::|....|..||:..||||....:..||||..:| ...|||.||
Zfish   513 SFAFMLPVATPPNAIVFSYGYLKVSDMAKTGIMMNIIGIFCITLAINTWGKAMF-NLDSFPAWA- 575

  Fly   555 EIKNQTKI 562
               |||.|
Zfish   576 ---NQTVI 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	186/529 (35%)
Indy-2	NP_001027201.1	dass	52..532	CDD:273267	186/526 (35%)
slc13a5b	XP_001345110.4	ArsB_NhaD_permease	31..568	CDD:304373	193/550 (35%)
slc13a5b	XP_001345110.4	CitT	36..561	CDD:223547	188/537 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580405
Domainoid	1	1.000	381	1.000	Domainoid score	I793
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1908
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm6448
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.000